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001-es BibID:	BIBFORM062076
Első szerző:	Csősz Éva (biokémikus, molekuláris biológus)
Cím:	Highly abundant defense proteins in human sweat as revealed by targeted proteomics and label-free quantification mass spectrometry / É. Csősz, G. Emri, G. Kallo, G. Tsaprailis, J. Tőzsér
Dátum:	2015
ISSN:	0926-9959
Megjegyzések:	Background The healthy human skin with its effective antimicrobial defense system forms an efficient barrier againstinvading pathogens. There is evidence suggesting that the composition of this chemical barrier varies between diseases,making the easily collected sweat an ideal candidate for biomarker discoveries.Objective Our aim was to provide information about the normal composition of the sweat, and to study the chemicalbarrier found at the surface of skin.Methods Sweat samples from healthy individuals were collected during sauna bathing, and the global protein panelwas analysed by label-free mass spectrometry. SRM-based targeted proteomic methods were designed and stableisotope labelled reference peptides were used for method validation.Results Ninety-five sweat proteins were identified, 20 of them were novel proteins. It was shown that dermcidin is themost abundant sweat protein, and along with apolipoprotein D, clusterin, prolactin-inducible protein and serum albumin,they make up 91% of secreted sweat proteins. The roles of these highly abundant proteins were reviewed; all of whichhave protective functions, highlighting the importance of sweat glands in composing the first line of innate immunedefense system, and maintaining the epidermal barrier integrity.Conclusion Our findings with regard to the proteins forming the chemical barrier of the skin as determined by label-freequantification and targeted proteomics methods are in accordance with previous studies, and can be further used as astarting point for non-invasive sweat biomarker research.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban epidermal barrier highly abundant sweat proteins label free quantification non-immune defense SRM targeted proteomics
Megjelenés:	Journal Of The European Academy Of Dermatology And Venereology. - 29 : 10 (2015), p. 2024-2031. -
További szerzők:	Emri Gabriella (1972-) (bőrgyógyász, allergológus, onkológus) Kalló Gergő (1989-) (molekuláris biológus) Tsaprailis, George Tőzsér József (1959-) (molekuláris biológus, biokémikus, vegyész)
Pályázati támogatás:	TÁMOP-4.2.2.A-11/1/KONV-2012-0045 TÁMOP Proteomika, Szemészet Kutatócsoport T AMOP-4.2.4.-A/2-11-1-2012-0001 TÁMOP Training Grant Number ? ES007091 Egyéb NIEHS grant ES06694 Egyéb NIH/NCI grant CA023074 Egyéb NIH/NCRR 1S10 RR028868-01 Egyéb
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001-es BibID:	BIBFORM036824
Első szerző:	Emri Eszter (Ph.D hallgató)
Cím:	Correlation among metallothionein expression, intratumoural macrophage infiltration and the risk of metastasis in human cutaneous malignant melanoma / E. Emri, K. Egervari, T. Varvölgyi, D. Rozsa, E. Miko, B. Dezső, I. Veres, G. Mehes, G. Emri, E. Remenyik
Dátum:	2013
ISSN:	0926-9959
Megjegyzések:	Background: The formation of metastases and the efficacy of systemic therapies in cutaneous malignant melanoma (CMM) depend on the characteristics of the tumour cells and the host immune response. Aberrant expression of metallothionein (MT) has been observed in several types of cancers with poor prognoses. Objective: To perform an immunohistochemical study on primary CMM comparing the MT expression of tumours without metastases (n = 23) to that of samples with haematogenous metastases (n = 23) and to examine the correlation between MT staining and immunological markers relevant in CMM progression. Methods: The immunohistochemical labelling of different tumour sections was analysed using tissue microarrays for the evaluation of the suitability of this method in future studies. Results: Our results suggest that MT overexpression is significantly more frequent in primary CMM with haematogenous metastases (P = 0.018) and that the overexpression is independent of the Breslow tumour thickness (R = 0.102, P = 0.501). Interestingly, MT overexpression of the tumour cells was correlated with the presence of tumour-infiltrating CD68(+) macrophages (P = 0.003), a known predictive factor for melanoma progression, thereby suggesting a role for MT in the development of a defective host immune response. Furthermore, the presence of CD163(+) macrophages infiltrating the tumours correlated with metastasis formation (P < 0.001), whereas the presence CD1a(+) dendritic cells surrounding the tumours was associated with a lower risk of haematogenous spread (P = 0.003). Conclusion: Our results demonstrate that MT may represent a suitable prognostic factor that can characterize the metastasising ability of CMM and the tumour-promoting host immune response.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban Egészség- és Környezettudomány
Megjelenés:	Journal of The European Academy of Dermatology and Venereology. - 27 : 3 (2013), p. e320-e327. -
További szerzők:	Egervári Kristóf (1983-) (patológus) Várvölgyi Tünde (1984-) (bőrgyógyász) Rózsa Dávid (1982-) (Ph.D hallgató) Mikó Edit (1980-) (biológus) Dezső Balázs (1951-) (pathológus) Veres Imre (1963-) (bőrgyógyász) Méhes Gábor (1966-) (patológus) Emri Gabriella (1972-) (bőrgyógyász, allergológus, onkológus) Remenyik Éva (1956-) (bőrgyógyász)
Pályázati támogatás:	TÁMOP-4.2.1/B-09/1/KONV-2010-0007 TÁMOP Az UV fény DNS károsító hatásának in vitro vizsgálata K68401 OTKA TÁMOP-4.2.2.-08/1-2008-0019 TÁMOP
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001-es BibID:	BIBFORM058676
Első szerző:	Gellén Emese (bőrgyógyász)
Cím:	Diagnostic accuracy of 18F-FDG-PET/CT in early and late stages of high-risk cutaneous malignant melanoma / E. Gellen, O. Santha,E. Janka, I. Juhasz, Z. Peter, I. Erdei, R. Lukacs, N. Fedinecz, L. Galuska, E. Remenyik, G. Emri
Dátum:	2015
ISSN:	0926-9959
Megjegyzések:	The precise role of total body 18 F-fluorodeoxyglucose-positron emission tomography/computed tomography (PET/CT) in the clinical management of patients with cutaneous malignant melanoma (CMM) is not well established.OBJECTIVE:The purpose of this study was to investigate the diagnostic accuracy of PET/CT in early- and late-stage patients with high-risk CMM.METHODS:We retrospectively analysed various imaging, histopathological and clinical data from 97 patients also examined by PET/CT during a 5-year period (2007-2011). Three groups were assessed: stage I/II, resected stage III and unresectable stage III/stage IV.RESULTS:The median follow-up time of living patients was 43.48 ? 19.67 (15-142) months. We observed a high diagnostic accuracy in all stages (91.3%, 92.5% and 96.2% respectively). PET/CT appeared to be reliable diagnostic tool even for the detection of small lymph node metastases. PET/CT was informative in 14 of 19 cases wherein another imaging examination provided inconclusive results regarding lesion dignity. However, PET/CT was less suitable for properly evaluating the dignity of a lung lesion. A true positive scan was twice as likely in clinically negative patients with resected stage III disease than in patients with stage I/II disease (35.9% and 14.5%, P = 0.007).CONCLUSIONS:These results confirm that PET/CT is an important diagnostic tool in the management of patients with high-risk CMM, but it cannot replace the standard of care examinations. More accurate clinicopathological and timing criteria must be defined to best utilize the advantages of this imaging method.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban diagnostic accuracy high-risk CMM PET/CT cutaneous malignant melanoma
Megjelenés:	Journal Of The European Academy Of Dermatology And Venereology 29 : 10 (2015), p. 1938-1944. -
További szerzők:	Sántha Orsolya Janka Eszter Anna (1989-) (bőrgyógyász, népegészségügyi szakember) Juhász István (1956-) (bőrgyógyász, bőrsebész, kozmetológus, klinikai onkológus) Péter Zoltán (1964-) (bőrgyógyász) Erdei Irén (1955-) (bőrgyógyász, aneszteziológus és intenzívterápiás szakorvos) Lukács R. Fedinecz Nikol (radiológus szakorvos) Galuska László (1946-) (belgyógyász, izotópdiagnoszta) Remenyik Éva (1956-) (bőrgyógyász) Emri Gabriella (1972-) (bőrgyógyász, allergológus, onkológus)
Pályázati támogatás:	NK101680 OTKA K105872 OTKA TÁMOP-4.2.2.A-11/1/KONV-2012-0031 TÁMOP
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001-es BibID:	BIBFORM113555
035-os BibID:	(scopus)85150806416 (wos)000949394200001
Első szerző:	Liszkay Gabriella (Budapest)
Cím:	Significant improvement in melanoma survival over the last decade : A Hungarian nationwide study between 2011 and 2019 / Liszkay Gabriella, Benedek Angela, Polgár Csaba, Oláh Judit, Holló Péter, Emri Gabriella, Csejtei András, Kenessey István, Polányi Zoltán, Knollmajer Kata, Várnai Máté, Vokó Zoltán, Nagy Balázs, Rokszin György, Fábián Ibolya, Barcza Zsófia, Gyulai Rolland, Kiss Zoltan
Dátum:	2023
ISSN:	0926-9959
Megjegyzések:	Background: Recent real-world studies have reported significant improvements in the survival of malignant melanoma in the past few years, mainly as a result of modern therapies. However, long-term survival data from Central Eastern European countries such as Hungary are currently lacking. Methods: This nationwide, retrospective study examined melanoma survival in Hungary between 2011?2019 using the databases of the National Health Insurance Fund (NHIF) and Central Statistical Office (CSO) of Hungary. Crude overall survival and age-standardized 5-year net survival as well as the association between age, sex and survival were calculated. Results: Between 2011 and 2019, 22,948 newly diagnosed malignant melanoma cases were recorded in the NHIF database (47.89% male, mean age: 60.75 years (SD: ?16.39)). Five-year overall survival was 75.40% (women: 80.78%; men: 69.52%). Patients diagnosed between 2017?2019 had a 20% lower risk of mortality compared to patients diagnosed between 2011?2012 (HR 0.80, 95% CI 0.73?0.89; p < 0.0001). Age-standardized 5-year net survival rates in 2011?2014 and 2015?2019 were 90.6% and 95.8%, respectively (women: 93.1% and 98.4%, men: 87.8% and 92.7%, respectively). The highest age-standardized 5-year net survival rates were found in the 0?39 age cohort (94.6% in the 2015?2019 period). Conclusion: Hungary has similar melanoma survival rates to Western Europeancountries. Based on net survival, the risk of dying of melanoma within 5 years was cut by more than half (55%) during the study period, which coincides with the successful implementation of awareness campaigns and the wide availability of modern therapies.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk
Megjelenés:	Journal Of The European Academy Of Dermatology And Venereology. - 37 : 5 (2023), p. 932-940. -
További szerzők:	Benedek Angéla Polgár Csaba Oláh Judit Holló Péter Emri Gabriella (1972-) (bőrgyógyász, allergológus, onkológus) Csejtei András Kenessey István Polányi Zoltán Knollmajer Kata Várnai Máté Vokó Zoltán (1968-) (epidemiológus) Nagy Balázs Rokszin György Fábián Ibolya Barcza Zsófia Gyulai Rolland Kiss Zoltán (Budapest)
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