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001-es BibID:	BIBFORM122571
035-os BibID:	(Scopus)85128249106 (WOS)000815784200046
Első szerző:	De Smedt, Julie
Cím:	Determinants of 25-hydroxyvitamin D Status in a Cutaneous Melanoma Population / Julie De Smedt, Sofie Van Kelst, Laudine Janssen, Vivien Marasigan, Veerle Boecxstaens, Marguerite Stas, Dirk Vanderschueren, Ipek Guler, Kris Bogaerts, Katleen Vandenberghe, Oliver Bechter, Jaak Billen, Arjen Nikkels, Tine Strobbe, Gabriella Emri, Diether Lambrechts, Marjan Garmyn
Dátum:	2022
ISSN:	0001-5555
Megjegyzések:	Vitamin D status is influenced by well-known deter-minants, but factors associated with low 25-hydroxy-vitamin D levels in the cutaneous melanoma popula-tion are not well defined. The aim of this study was to confirm the well-known determinants and to assess new determinants for 25-hydroxyvitamin D levels in a cutaneous melanoma population. In a prospectively included cohort of 387 patients with cutaneous mela-noma the association of 25-hydroxyvitamin D levels with sex, age, body mass index, time of blood with-drawal, Fitzpatrick phototype, vitamin D supplemen-tation, score for intensity of lifetime sun exposure, smok ing, education level, hair and skin colour, eye colour, total number of benign naevi, freckles and pa-rameters of chronic sun damage was investigated. In addition, 25-hydroxyvitamin D levels were correlated with pathological parameters of the primary tumour and melanoma stage (8th edition of the American Joint Committee on Cancer (AJCC). Univariate and multi-variate logistic regressions were performed using R software. The following factors had a significant effect on vitamin D status: body mass index, seasonal time of blood sampling, vitamin D supplementation, and a subtype of skin, and hair colour.
Tárgyszavak:	idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk melanoma vitamin D body mass index
Megjelenés:	Acta Dermato-Venereologica. - 102 (2022), p. 1-7. -
További szerzők:	Van Kelst, Sofie Janssen, Laudine Marasigan, Vivien Boecxstaens, Veerle Stas, Marguerite Vanderschueren, Dirk Guler, Ipek Bogaerts, Kris Vandenberghe, Katleen Bechter, Oliver Billen, Jaak Nikkels, Arjen Strobbe, Tinne Emri Gabriella (1972-) (bőrgyógyász, allergológus, onkológus) Lambrechts, Dieter (1976-) (genetikus) Garmyn, Marjan
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM119632
035-os BibID:	(Scopus)85186383343
Első szerző:	De Smedt, Julie
Cím:	Clinical and genetic determinants of vitamin D receptor expression in cutaneous melanoma patients / Julie De Smedt, Claudia Aura, Sofie Van Kelst, Laudine Janssen, Vivien Marasiganc, Veerle Boecxstaens, Marguerite Stas, Kris Bogaerts, Ann Belmans, Isabelle Cleynen, Dirk Vanderschueren, Katleen Vandenberghe, Oliver Bechter, Arjen Nikkels, Tinne Strobbe, Gabriella Emri, Dieter Lambrechts, Marjan Garmyn
Dátum:	2024
ISSN:	0960-8931
Megjegyzések:	Decrease of vitamin D receptor (VDR) expression is observed in melanocytic naevi and melanoma compared to normal skin. Little is known about factors influencing VDR expression in cutaneous melanoma (CM). We investigated the correlation of VDR expression in CM with 25-hydroxy vitamin D (25OHD) levels, demographic/clinical parameters, genetic variants of VDR and pathology of the primary tumor. Demographic/clinical parameters were recorded in 407 prospectively recruited CM patients of a multi-center controlled study (ViDMe trial). We determined VDR expression both in the nucleus and in the cytoplasm by semi-quantitative assessment in CM tissue using histochemistry in 279 patients, expressed in percentages and histoscore (H-score). Genomic DNA from 332 patients was extracted to genotype thirteen VDR single nucleotide polymorphisms (SNPs) using TaqMan. VDR expression in CM tissue from 279 patients was correlated with clinical/ demographic parameters and 25OHD levels (univariable and multivariable analysis), VDR SNPs (univariable analysis) and pathology parameters of primary CM tissue (univariable analysis). Cytoplasmic VDR expression was increased in patients who stated to have a high sun exposure during their life compared to patients with low sun exposure (pH-score,univariable: 0.001, pH-score,multivariable: 0.004). The A allele of the genetic VDR polymorphism Fok1 was associated with a higher expression of the VDR in the cytoplasm (pcytoplasmic, univariable: 0.001 and pH-score, univariable: 0.02). In the primary tumor, presence of mitosis (pnucleus,%, univariable: 0.002) and perineural invasion (pnucleus,%,univariable: 0.03) were significantly associated with low nuclear VDR expression.
Tárgyszavak:	Orvostudományok Egészségtudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk cutaneous melanoma vitamin D receptor vitamin D receptor polymorphisms
Megjelenés:	Melanoma Research. - 34 : 2 (2024), p. 125-133. -
További szerzők:	Aura, Claudia Van Kelst, Sofie Janssen, Laudine Marasigan, Vivien Boecxstaens, Veerle Stas, Marguerite Bogaerts, Kris Belmans, Ann Cleynen, Isabelle Vanderschueren, Dirk Vandenberghe, Katleen Bechter, Oliver Nikkels, Arjen Strobbe, Tinne Emri Gabriella (1972-) (bőrgyógyász, allergológus, onkológus) Lambrechts, Dieter (1976-) (genetikus) Garmyn, Marjan
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM077341
Első szerző:	De Smedt, J.
Cím:	Vitamin D supplementation in cutaneous malignant melanoma outcome (ViDMe) : a randomized controlled trial. / J. De Smedt, S. Van Kelst, V. Boecxstaens, M. Stas, K. Bogaerts, D. Vanderschueren, C. Aura, K. Vandenberghe, D. Lambrechts, P. Wolter, O. Bechter, A. Nikkels, T. Strobbe, G. Emri, V. Marasigan, M. Garmyn
Dátum:	2017
ISSN:	1471-2407 1471-2407
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	BMC Cancer. - 17 : 1 (2017), p. 1-10. -
További szerzők:	Van Kelst, Sofie Boecxstaens, Veerle Stas, Marguerite Bogaerts, Kris Vanderschueren, Dirk Aura, Claudia Vandenberghe, Katleen Lambrechts, Dieter (1976-) (genetikus) Wolter, P. Bechter, Oliver Nikkels, Arjen Strobbe, Tinne Emri Gabriella (1972-) (bőrgyógyász, allergológus, onkológus) Marasigan, Vivien Garmyn, Marjan
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat
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