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001-es BibID:BIBFORM028387
Első szerző:Kirov, Mikhail Y.
Cím:Aerosolized linear polyethylenimine-nitric oxide/nucleophile adduct attenuates endotoxin-induced lung injury in sheep / Mikhail Y. Kirov, Oleg V. Evgenov, Vladimir N. Kuklin, László Virág, Pál Pacher, Garry J. Southan, Andrew L. Salzman, Csaba Szabó, Lars J. Bjertnaes
Dátum:2002
ISSN:1073-449X
Megjegyzések:Pulmonary hypertension and edema are mainstays of acute lung injury (ALI). We synthesized linear polyethylenimine-nitric oxide/nucleophile adduct (DS-1), a water-soluble nitric oxide donor, and demonstrated that it is a potent relaxant of precontracted rat aortic rings without inducing desensitization. Moreover, DS-1 does not suppress the viability of human pulmonary epithelial cells in vitro. We also tested whether DS-1 counteracts ALI in endotoxemic sheep. Animals were instrumented for a chronic study. In 16 awake, spontaneously breathing sheep, Escherichia coli endotoxin (10 ng/kg/minute) was infused for 8 hours. From 2 hours of endotoxemia, sheep received either nebulized DS-1 (1 mg/kg/hour) or isotonic saline. DS-1 reduced endotoxin-induced rises in pulmonary arterial and microwedge pressures and vascular resistance index by 40-70%. In parallel, DS-1 decreased the accumulation of extravascular lung water by 60-70% and reduced the increment in right ventricle stroke work index and the falls in right ventricle ejection fraction, stroke volume, and left ventricle stroke work indices. Furthermore, DS-1 reduced venous admixture and improved arterial oxygen saturation. In four healthy animals, DS-1 alone slightly increased arterial oxygenation but had no other effects. Thus, aerosolized DS-1 attenuates endotoxin-induced ALI in sheep by reducing pulmonary hypertension and edema and improving myocardial function and gas exchange.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
acute lung injury
pulmonary circulation
extravascular lung water
nitric oxide donor
endotoxin
külföldön készült közlemény
Megjelenés:American Journal Of Respiratory And Critical Care Medicine 166 : 11 (2002), p. 1436-1442. -
További szerzők:Evgenov, Oleg V. Kuklin, Vladimir N. Virág László (1965-) (biokémikus, sejtbiológus, farmakológus) Pacher Pál Southan, Garry J. Salzman, Andrew L. Szabó Csaba (1967-) (orvos) Bjertnaes, Lars J.
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DOI
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001-es BibID:BIBFORM028376
Első szerző:Liaudet, Lucas
Cím:Flagellin from gram-negative bacteria is a potent mediator of acute pulmonary inflammation in sepsis / Lucas Liaudet, Csaba Szabó, Oleg V. Evgenov, Kanneganti G. Murthy, Pál Pacher, László Virág, Jon G. Mabley, Anita Marton, Francisco G. Soriano, Mikhail Y. Kirov, Lars J. Bjertnaes, and Andrew L. Salzman
Dátum:2003
ISSN:1073-2322
Megjegyzések:Flagellin is a recently identified bacterial product that elicits immune response via toll-like receptor 5. Here, we demonstrate that flagellin is an extraordinarily potent proinflammatory stimulus in the lung during sepsis. In vitro, flagellin triggers the production of interleukin (IL)-8 by human lung epithelial (A549) cells, with 50% of the maximal response obtained at a concentration of 2 x 10(-14) M. Flagellin also induces the expression of ICAM-1 in vitro. Intravenous administration of flagellin to mice elicited a severe acute lung inflammation that was significantly more pronounced than following lipopolysaccharide (LPS) administration. Flagellin induced a local release of proinflammatory cytokines, the accumulation of inflammatory cells, and the development of pulmonary hyperpermeability. These effects were associated with the nuclear translocation of the transcription NF-kappaB in the lung. Flagellin remained active in inducing pulmonary inflammation at doses as low as 10 ng/mouse. In the plasma of patients with sepsis, flagellin levels amounted to 7.1 +/- 0.1 ng/mL. Plasma flagellin levels showed a significant positive correlation with the lung injury score, with the alveolar-arterial oxygen difference as well as with the duration of the sepsis. Flagellin emerges as a potent trigger of acute respiratory complications in gram-negative bacterial sepsis.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
endotoxin shock
chemokines
bacterial infection
inflammation
lung
külföldön készült közlemény
Megjelenés:Shock 19 : 2 (2003), p. 131-137. -
További szerzők:Szabó Csaba (1967-) (orvos) Evgenov, Oleg V. Murthy, Kanneganti G. Pacher Pál Virág László (1965-) (biokémikus, sejtbiológus, farmakológus) Mabley, Jon G. Marton Anita Soriano, Francisco Garcia Kirov, Mikhail Y. Bjertnaes, Lars J. Salzman, Andrew L.
Internet cím:DOI
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