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001-es BibID:	BIBFORM028421
Első szerző:	Whalen, Michael J.
Cím:	Reduction of cognitive and motor deficits after traumatic brain injury in mice deficient in poly(ADP-ribose) polymerase / Michael J. Whalen, Robert S. B. Clark, C. Edward Dixon, Paul Robichaud, Donald W. Maion, Vincent Vagni, Steven H. Graham, László Virág, György Haskó
Dátum:	1999
ISSN:	0271-678X
Megjegyzések:	Poly(ADP-ribose) polymerase (PARP), or poly-(ADP-ribose) synthetase, is a nuclear enzyme that consumes NAD when activated by DNA damage. The role of PARP in the pathogenesis of traumatic brain injury (TBI) is unknown. Using a controlled cortical impact (CCI) model of TBI and mice deficient in PARP, the authors studied the effect of PARP on functional and histologic outcome after CCI using two protocols. In protocol 1, naive mice (n = 7 +/+, n = 6 -/-) were evaluated for motor and memory acquisition before CCI. Mice were then subjected to severe CCI and killed at 24 hours for immunohistochemical detection of nitrated tyrosine, an indicator of peroxynitrite formation. Motor and memory performance did not differ between naive PARP +/+ and -/- mice. Both groups showed nitrotyrosine staining in the contusion, suggest ing that peroxynitrite is produced in contused brain. In protoco 2, mice (PARP +/+, n = 8; PARP -/-, n = 10) subjected to CCI were tested for motor and memory function, and contusion volume was determined by image analysis. PARP -/- mice demonstrated improved motor and memory function after CC versus PARP +/+ mice (P < 0.05). However, contusion volume was not different between groups. The results suggest a detri mental effect of PARP on functional outcome after TBI.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban egyetemen (Magyarországon) készült közlemény
Megjelenés:	Journal of Cerebral Blood Flow And Metabolism 19 : 8 (1999), p. 835-842. -
További szerzők:	Clark, Robert S. B. Dixon, C. Edward Robichaud, Paul Maion, Donald W. Vagni, Vincent Graham, Steven Virág László (1965-) (biokémikus, sejtbiológus, farmakológus) Haskó György (1967-) (biokémikus)
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001-es BibID:	BIBFORM028400
Első szerző:	Whalen, Michael J.
Cím:	Traumatic brain injury in mice deficient in poly-ADP(ribose) polymerase : a preliminary report / M. J. Whalen, R. S. B. Clark, C. E. Dixon, P. Robichaud, D. W. Marion, V. Vagni, S. Graham, L. Virág, Gy. Haskó, R. Stachlewitz, Cs. Szabó, P. M. Kochanek
Dátum:	2000
ISSN:	0001-6268
Megjegyzések:	Poly (ADP-ribose) polymerase (PARP) is a ubiquitous nuclear enzyme that, when activated by free-radical induced DNA damage, contributes to energy failure and cell death in models of central nervous system ischemia and reperfusion. PARP contributes to neuronal cell death in vivo after cerebral ischemia/reperfusion, however, the role of PARP in the pathogenesis of traumatic brain injury (TBI) is unknown. We hypothesized that, compared to wild type mice (+/+), mice deficient in PARP (-/-) would have reduced motor and cognitive deficits after TBI. Mice underwent controlled cortical impact (CCI) (6 m/s, 1.2 mm depth) and were tested for motor (d 1-5) and cognitive (d 14-18) function after CCI. PARP -/- mice demonstrated improved motor performance and improved cognitive function after CCI (both p < 0.05 compared to +/+). This is the first study to evaluate a role for PARP in functional outcome after TBI. The results suggest a detrimental role for PARP in the pathogenesis of TBI.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban poly(ADP-ribose) polymerase brain injury mice egyetemen (Magyarországon) készült közlemény
Megjelenés:	Acta Neurochirurgica. Supplement. - 76 (2000), p. 61-64. -
További szerzők:	Clark, Robert S. B. Dixon, C. Edward Robichaud, Paul Marion, D. W. Vagni, Vincent Graham, Steven Virág László (1965-) (biokémikus, sejtbiológus, farmakológus) Haskó György (1967-) (biokémikus) Stachlewitz, Robert Szabó Csaba (1967-) (orvos) Kochanek, P. M.
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