CCL

Összesen 2 találat.
#/oldal:
Részletezés:
Rendezés:

1.

001-es BibID:BIBFORM077512
Első szerző:Kristóf Endre (általános orvos)
Cím:Interleukin-6 released from differentiating human beige adipocytes improves browning / Endre Kristóf, Ágnes Klusóczki, Roland Veress, Abhirup Shaw, Zsolt Sándor Combi, Klára Varga, Ferenc Győry, Zoltán Balajthy, Péter Bai, Zsolt Bacso, László Fésüs
Dátum:2019
ISSN:0014-4827
Megjegyzések:Brown and beige adipocytes contribute significantly to the regulation of whole body energy expenditure and systemic metabolic homeostasis not exclusively by thermogenesis through mitochondrial uncoupling. Several studies have provided evidence in rodents that brown and beige adipocytes produce a set of adipokines ("batokines") which regulate local tissue homeostasis and have beneficial effects on physiological functions of the entire body. We observed elevated secretion of Interleukin (IL)-6, IL-8 and monocyte chemoattractant protein (MCP)-1, but not tumor necrosis factor alpha (TNFα) or IL-1β pro-inflammatory cytokines, by ex vivo differentiating human beige adipocytes (induced by either PPARγ agonist or irisin) compared to white. Higher levels of IL-6, IL-8 and MCP-1 were released from human deep neck adipose tissue biopsies (enriched in browning cells) than from subcutaneous ones. IL-6 was produced in a sustained manner and mostly by the adipocytes and not by the undifferentiated progenitors. Continuous blocking of IL-6 receptor by specific antibody during beige differentiation resulted in downregulation of brown marker genes and increased morphological changes that are characteristic of white adipocytes. The data suggest that beige adipocytes adjust their production of IL-6 to reach an optimal level for differentiation in the medium enhancing browning in an autocrine manner.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Experimental Cell Research. - 377 : 1-2 (2019), p. 47-55. -
További szerzők:Klusóczki Ágnes (1991-) (biotechnológus) Veress Roland (1992-) (molekuláris biológus) Shaw, Abhirup (1992-) Combi Zsolt Varga Klára Győry Ferenc (1969-) (kardiológus) Balajthy Zoltán (1957-) (biokémikus, sejtbiológus) Bai Péter (1976-) (biokémikus) Bacsó Zsolt (1963-) (biofizikus) Fésüs László (1947-) (orvos biokémikus)
Pályázati támogatás:GINOP-2.3.2-15-2016-00006
GINOP
OTKA-NK105046
OTKA
OTKA-K123975
OTKA
ÚNKP-18-4
ÚNKP
Internet cím:Szerző által megadott URL
DOI
Intézményi repozitóriumban (DEA) tárolt változat
Borító:

2.

001-es BibID:BIBFORM067761
Első szerző:Kristóf Endre (általános orvos)
Cím:Browning-inducers modify the differentiation of human adipocytes from different anatomical sites and enhance their mitochondrial respiration / Kristóf Endre, Quang-Minh Doan-Xuan, Klusóczki Ágnes, Győry Ferenc, Póliska Szilárd, Bacsó Zsolt, Bai Péter, Fésüs László
Dátum:2016
Megjegyzések:Several studies highlighted the strong negative correlation between obesity and active brown adipose tissue amount in adult humans. There are at least two types of thermogenic fat depots, classical brown and beige, which have different origins and tissue distribution. We intended to clarify whether preadipocytes from different anatomical sites are capable of initiating a browning program in parallel with the enhancement of mitochondrial respiration in response to browning-inducers. Preadipocytes obtained from herniotomy (abdominal subcutaneous) or thyroid surgery ("deep neck" and cervical subcutaneous) and a human preadipocyte cell line (SGBS) were differentiated into white, brown (by BMP7 treatment) or beige (by irisin and clozapine administration or by a previously described cocktail) adipocytes. To assess browning, gene expression measurements and laser-scanning cytometry based morphology analysis were performed. Oxygen consumption was measured using an XF96 oxymeter. Differentiating adipocytes treated with browning-inducers had smaller lipid droplets, more mitochondrial DNA, higher mitochondrial respiration and contained more Ucp1 protein than white adipocytes. Browning adipocytes utilize more fatty acids by beta-oxidation and increase their respiration by activating a futile cycle of creatine metabolism. Next, we intend to identify molecular markers to characterize those preadipocytes that are capable to implement an effective browning program.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idézhető absztrakt
Megjelenés:Journal of World Mitochondria Society. - 2 : 2 (2016), p. 23. -
További szerzők:Doan-Xuan, Quang-Minh (1986-) (biofizikus) Klusóczki Ágnes (1991-) (biotechnológus) Győry Ferenc (1969-) (kardiológus) Póliska Szilárd (1978-) (biológus) Bacsó Zsolt (1963-) (biofizikus) Bai Péter (1976-) (biokémikus) Fésüs László (1947-) (orvos biokémikus)
Pályázati támogatás:NK 105046
OTKA
GINOP-2.3.2-15-2016-00006
GINOP
Internet cím:Szerző által megadott URL
DOI
Intézményi repozitóriumban (DEA) tárolt változat
Borító:
Rekordok letöltése1