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001-es BibID:	BIBFORM040665
035-os BibID:	PMID:11550968
Első szerző:	Sipka Sándor (laboratóriumi szakorvos)
Cím:	Decreased arachidonic acid release in peripheral blood monocytes of patients with systemic lupus erythematosus / Sándor Sipka, Sándor Szántó, Kornélia Szűcs, Ildikó Kovács, Emese Kiss, Péter Antal-Szalmás, Gabriella Lakos, Magdolna Aleksza, Árpád Illés, Pál Gergely, Gyula Szegedi
Dátum:	2001
Megjegyzések:	OBJECTIVE: To investigate the release of arachidonic acid (AA) in unfractionated peripheral blood mononuclear cells (PBMC), separated monocytes and T lymphocytes of patients with systemic lupus erythematosus (SLE). METHODS: AA release was measured in cells from 56 patients with SLE and from 48 controls. Of the 56 patients with SLE, 38 were receiving glucocorticosteroids and 18 were not. [3H]AA was incorporated into the membranes of PBMC and purified subsets of monocytes and T lymphocytes. The release of [3H]AA was measured both in nonstimulated cells cultured for 24 h and in cell cultures stimulated by phorbol ester (PMA) and Ca2+ ionophore for 4 h. RESULTS: In the PBMC of SLE patients not taking glucocorticosteroids, the release of AA was decreased in both stimulated and nonstimulated cells. There was a decrease of AA production in monocytes but not in T lymphocytes. This phenomenon could be observed in the active and inactive phases of the disease. CONCLUSION: A defect in AA production may exist in the peripheral monocytes of patients with SLE, resulting in decreased release of AA in patients not receiving glucocorticosteroid therapy.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban Adolescent Adult Aged Arachidonic Acid/analysis/biosynthesis Biological Markers/blood Cells, Cultured Female Glucocorticoids/administration & dosage Humans Lupus Erythematosus, Systemic/blood/drug therapy Male Middle Aged Monocytes/metabolism Prognosis Reference Values Sensitivity and Specificity Severity of Illness Index egyetemen (Magyarországon) készült közlemény
Megjelenés:	The Journal of Rheumatology. - 28 : 9 (2001), p. 2012-2017. -
További szerzők:	Szántó Sándor (1968-) (belgyógyász, reumatológus) Szűcs Kornélia (1945-) (biokémikus) Kovács Ildikó Kiss Emese (1960-) (belgyógyász, immunológus) Antal-Szalmás Péter (1968-) (laboratóriumi szakorvos) Lakos Gabriella (1963-) (laboratóriumi szakorvos, transzfúziológus, immunológus) Aleksza Magdolna Illés Árpád (1959-) (belgyógyász, haematológus, onkológus) Gergely Pál (1947-) (biokémikus) Szegedi Gyula (1936-2013) (belgyógyász, immunológus)
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM039762
035-os BibID:	PMID:12095708
Első szerző:	Szántó Sándor (belgyógyász, reumatológus)
Cím:	Inhibition of arachidonic acid release from human peripheral mononuclear cells by heat shock treatment and geldanamycin / Sándor Szántó, Péter Csermely, Ildikó Kovács, József Csongor, Árpád Illés, Gyula Bakó, Gyula Szegedi, Sándor Sipka
Dátum:	2002
ISSN:	0165-2478
Megjegyzések:	The objective of this study was to investigate the effects of heat shock (HS) treatment and geldanamycin (GA) on the release of arachidonic acid (AA) from human peripheral blood mononuclear cells (PBMC), monocytes and lymphocytes. Mononuclear cells prepared from blood of healthy subjects were preincubated with (3)H-AA. The release of (3)H-AA incorporated into the membrane was studied after pretreatment of cells by HS (43 degrees C, 1 h) and GA. The activation of AA producing enzymes was achieved by the addition of phorbol 12-myristate 13-acetate (PMA) or by the combination of PMA+calcium ionophore A-23187. Treatment of cells by HS inhibited the release of AA. Furthermore, the release of AA by PBMC was dose dependently inhibited by GA. The combination of treatments by HS and GA augmented the inhibition of AA release. The HS response involves a diminished release of AA from PBMC. The inhibitory effect of GA on the AA release is a new element in the antiinflammatory pharmacological ability of this drug.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban Arachidonic Acid/analysis/*secretion Benzoquinones Calcimycin/pharmacology Cells, Cultured Enzyme Inhibitors/pharmacology Heat-Shock Response/physiology Hot Temperature Humans Ionophores/pharmacology Lactams, Macrocyclic Leukocytes, Mononuclear/chemistry/drug effects/metabolism Quinones/pharmacology Tetradecanoylphorbol Acetate/pharmacology egyetemen (Magyarországon) készült közlemény
Megjelenés:	Immunology Letters. - 83 : 3 (2002), p. 181-185. -
További szerzők:	Csermely Péter Kovács Ildikó Csongor József Illés Árpád (1959-) (belgyógyász, haematológus, onkológus) Bakó Gyula (1951-) (belgyógyász) Szegedi Gyula (1936-2013) (belgyógyász, immunológus) Sipka Sándor (1945-) (laboratóriumi szakorvos)
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM047793
Első szerző:	Váróczy László (belgyógyász, haematológus)
Cím:	Changes in the Number of CD8+ T Lymphocytes in the Peripheral Blood of Patients with Various Autoimmune Diseases after Autologous Hematopoietic Stem Cell Transplantations and their Relations to the Survival Times / László Váróczy, Ildikó Kovács, Sándor Baráth, Edit Gyimesi, Árpád Illés, Margit Zeher, Sándor Sipka
Dátum:	2013
Megjegyzések:	The changes in the number of CD8(+) T lymphocytes were studied before (0 day) and then 30 days after the autologous hematopoietic stem cell transplantations (AHSCT) in 14 therapy refractory patients with autoimmune diseases. The years of survival and the clinical states were also evaluated. The number of CD8(+) T cells was determined by an hematologic automat and by flow cytometry. Longer than 5-year survival times were found in 6 cases, whereas there was no progression (improvement) in 2 cases, and 4 patients were lost. The increase in the number of CD8(+) cytotoxic T cells was gradual in the first 2 months and reached the significantly highest values among all subtypes of lymphocytes. It was of a special interest that in all the 4 patients who died, the numbers of CD8(+) T cells were less than 150/?l on the 30th day after AHSCT, whereas all the 10 patients with a higher cell number survived. These results suggest that the early monitoring of the number (not only the ratio) of regenerating CD8(+) T cells in the peripheral blood can be a useful and quantitative laboratory measurement after AHSCT, and it has a significant relation also to the survival times of transplanted patients.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban CD8+ T lymphocytes autologous stem cell transplantation autoimmune
Megjelenés:	Archivum Immunologiae et Therapiae Experimentalis. - 61 : 5 (2013), p. 421-426. -
További szerzők:	Kovács Ildikó Baráth Sándor (1977-) (biológus) Gyimesi Edit (1957-) (klinikai biokémikus, vegyész) Illés Árpád (1959-) (belgyógyász, haematológus, onkológus) Zeher Margit (1957-2018) (belgyógyász, allergológus és klinikai immunológus, reumatológus) Sipka Sándor (1945-) (laboratóriumi szakorvos)
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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