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001-es BibID:	BIBFORM091915
035-os BibID:	(WoS)000562771200009 (Scopus)85089407724
Első szerző:	DiNardo, Courtney D.
Cím:	Azacitidine and Venetoclax in Previously Untreated Acute Myeloid Leukemia / C. D. DiNardo, B. A. Jonas, V. Pullarkat, M. J. Thirman, J. S. Garcia, A. H. Wei, M. Konopleva, H. Döhner, A. Letai, P. Fenaux, E. Koller, V. Havelange, B. Leber, J. Esteve, J. Wang, V. Pejsa, R. Hájek, K. Porkka, Á. Illés, D. Lavie, R. M. Lemoli, K. Yamamoto, S.-S. Yoon, J. H. Jang, Su-Peng Yeh, M. Turgut, Wan-Jen Hong, Y. Zhou, J. Potluri, K. W. Pratz
Dátum:	2020
ISSN:	0028-4793
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk
Megjelenés:	New England Journal Of Medicine. - 383 : 7 (2020), p. 617-629. -
További szerzők:	Jonas, Brian A. Pullarkat, Vinod Thirman, Michael J. Garcia, Jacqueline S. Wei, Andrew H. Konopleva, Marina Döhner, Hartmut Letai, Anthony Fenaux, Pierre Koller, Elizabeth Havelange, Violaine Leber, Brian Esteve, Jordi Wang, Jianxiang Pejsa, Vlatko Hájek, Roman Porkka, Kimmo Illés Árpád (1959-) (belgyógyász, haematológus, onkológus) Lavie, David Lemoli, Roberto M. Yamamoto, Kazuhito Yoon, Sung-Soo Jang, Jun Ho Yeh, Su-Peng Turgut, Mehmet Hong, Wan-Jen Zhou, Ying Potluri, Jalaja Pratz, Keith W.
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM115904
035-os BibID:	(cikkazonosító)e963 (WoS)001096083700001 (Scopus)85175712230
Első szerző:	Kiladjian, Jean-Jacques
Cím:	Momelotinib in Myelofibrosis Patients With Thrombocytopenia : Post Hoc Analysis From Three Randomized Phase 3 Trials / Kiladjian Jean-Jacques, Vannucchi Alessandro M., Gerds Aaron T., Gupta Vikas, Verstovsek Srdan, Egyed Miklos, Platzbecker Uwe, Mayer Jirí, Grosicki Sebastian, Illés Árpád, Woźny Tomasz, Oh Stephen T., McLornan Donal, Kirgner Ilya, Yoon Sung-Soo, Harrison Claire N., Klencke Barbara, Huang Mei, Kawashima Jun, Mesa Ruben
Dátum:	2023
ISSN:	2572-9241
Megjegyzések:	The oral activin A receptor type I, Janus kinase 1 (JAK1), and JAK2 inhibitor momelotinib demonstrated symptom, spleen, and anemia benefits in intermediate- and high-risk myelofibrosis (MF). Post hoc analyses herein evaluated the efficacy and safety of momelotinib in patients with MF and thrombocytopenia (platelet counts <100 x 109/L) from randomized phase 3 studies: MOMENTUM (momelotinib versus danazol; JAK inhibitor experienced); SIMPLIFY-1 (momelotinib versus ruxolitinib; JAK inhibitor naive); and SIMPLIFY-2 (momelotinib versus best available therapy; JAK inhibitor experienced); these studies were not statistically powered to assess differences in thrombocytopenic subgroups, and these analyses are descriptive. The treatment effect of momelotinib versus ruxolitinib on week 24 response rates (spleen volume reduction >= 35%/Total Symptom Score reduction >= 50%/transfusion independence) was numerically comparable or better in thrombocytopenic patients versus the overall JAK inhibitor naive population; rates were preserved with momelotinib in thrombocytopenic patients but attenuated with ruxolitinib (momelotinib: 27%/28%/67% overall versus 39%/35%/61% in thrombocytopenic group; ruxolitinib: 29%/42%/49% overall versus 0%/22%/39% in thrombocytopenic group, respectively). In contrast to ruxolitinib, momelotinib maintained high dose intensity throughout the treatment. In the JAK inhibitor experienced population, thrombocytopenic patients had the following: (1) numerically higher symptom and transfusion independence response rates with momelotinib than in control arms; and (2) preserved spleen, symptom, and transfusion independence response rates with momelotinib relative to the overall study populations. The safety profile of momelotinib in thrombocytopenic patients was also consistent with the overall study population. In summary, momelotinib represents a safe and effective treatment option for patients with MF and moderate-to-severe thrombocytopenia.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk MOMELOTINIB MYELOFIBROSIS
Megjelenés:	HemaSphere. - 7 : 11 (2023), p. 1-15. -
További szerzők:	Vannucchi, Alessandro Maria Gerds, Aaron T. Gupta, Vikas Verstovsek, Srdan Egyed Miklós Platzbecker, Uwe Mayer, Jiri Grosicki, Sebastian Illés Árpád (1959-) (belgyógyász, haematológus, onkológus) Woźny, Tomasz Oh, Stephen T. McLornan, Donal P. Kirgner, Ilya Yoon, Sung-Soo Harrison, Claire N. Klencke, Barbara J. Huang, Mei Kawashima, Jun Mesa, Ruben
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