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001-es BibID:	BIBFORM035093
Első szerző:	Gulyás Balázs
Cím:	Regional glucose metabolic rates in the human brain : a PET study / Gulyás B., Trón L., Balkay L., Emri M., Molnár T., Tóth G., Márián T.
Dátum:	1996
Megjegyzések:	With the purpose of determining the regional cerebral glucose metabolic rates (rCMRglu) in the normal human brain in resting state, we measured with PET and FOG, as the tracer, the distribution of regional radioactivity levels in the brains of seven young healthy volunteers. The individual brain images were stereotactically standardised with the help of a computerised brain atlas. In the next steps, the global cerebral glucose metabolic rate (gCMRglu) in the individual subjects was normalised to 34 mumol/ 100 g/min, followed by the averaging of the stereotactically standardised and metabolically normalised brain images across the subject population. In the final step, on the basis of high precision anatomical information, three-dimensional (3-D) volumes-of-interest (VOI's), covering over thirty anatomical structures in the brain, were created and the rCMRglu values inside the VOI's were determined in the averaged image. The present measurements of the rCMRglu values are in outstanding agreement with those determined in earlier quantitative PET-FDG studies, demonstrating that stereotactically standardised and metabolically normalised images of regional radioactivity distributions in the brain can be used for quantitative determination of rCMRglu values.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény hazai lapban egyetemen (Magyarországon) készült közlemény
Megjelenés:	Acta Biologica Hungarica 47 : 1-4 (1996), p. 157-172. -
További szerzők:	Trón Lajos (1941-) (biofizikus) Balkay László (1963-) (biofizikus) Emri Miklós (1962-) (fizikus) Molnár T. (orvos) Tóth G. Márián Teréz (1950-) (radiobiológus)
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001-es BibID:	BIBFORM029944
Első szerző:	Márián Teréz (radiobiológus)
Cím:	Hypoglycemia activates compensatory mechanism of glucose metabolism of brain / Marian, T., Balkay, L., Fekete, I., Lengyel, Z., Veress, G., Esik, O., Tron, L., Krasznai, Z.
Dátum:	2001
ISSN:	0236-5383
Megjegyzések:	The effect of plasma glucose concentration on the cerebral uptake of [18F]-fluorodeoxy-D-glucose (FDG) was studied in a broad concentration range in a rabbit brain model using dynamic FDG PET measurements. Hypoglycemic and hyperglycemic conditions were maintained by manipulating plasma glucose applying i.v. glucose or insulin load. FDG utilization (K) and cerebral glucose metabolic rate (CGMR) were evaluated in a plasma glucose concentration range between 0.5 mM and 26 mM from the kinetic constant k1, k2, k3 obtained by the Sokoloff model of FDG accumulation. A decreasing set of standard FDG uptake values found with increasing blood glucose concentration was explained by competition between the plasma glucose and the radiopharmacon FDG. A similar trend was observed for the forward kinetic constants k1, and k3 in the entire concentration range studied. The same decreasing tendency of k2 was of a smaller magnitude and was reverted at the lowest glucose concentrations where a pronounced decrease of this backward transport rate constant was detected. Our kinetic data indicate a modulation of the kinetics of carbohydrate metabolism by the blood glucose concentration and report on a special mechanism compensating for the low glucose supply under conditions of extremely low blood glucose level.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény hazai lapban
Megjelenés:	Acta Biologica Hungarica. - 52 : 1 (2001), p. 35-45. -
További szerzők:	Balkay László (1963-) (biofizikus) Fekete István (1951-) (neurológus, pszichiáter) Lengyel Zsolt (nukleáris medicina szakorvos) Veress Gábor (1971-) (neurobiológus) Ésik Olga Trón Lajos (1941-) (biofizikus) Krasznai Zoltán (1950-) (biofizikus)
Internet cím:	DOI Intézményi repozitóriumban (DEA) tárolt változat
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