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001-es BibID:	BIBFORM005987
Első szerző:	Pieri, Carlo
Cím:	Ligand and voltage gated sodium channels may regulate electrogenic pump activity in human, mouse and rat lymphocytes / C. Pieri, R. Recchioni, F. Moroni, L. Balkay, T. Márián, L. Trón, S. Damjanovich
Dátum:	1989
Megjegyzések:	Bretylium tosylate - a sodium channel opener - resulted in an increase of membrane potential of depolarized human, rat and mouse T and B lymphocytes. Flow cytometric membrane potential measurements with bis-oxonol revealed that the above hyperpolarizing effect was amiloride, ouabain, tetrodotoxin, azide and temperature sensitive. The effect showed an absolute dependence on the extracellular sodium but it was insensitive to the extracellular Ca2+ level. The voltage gating of the effect can be eliminated by either an increase of the extracellular potassium concentration or low doses of veratrin. The existence of a voltage and ligand gated sodium channel is suggested in the plasma membrane of all kinds of lymphocytes. The hyperpolarization is explained by an increased activity of the electrogenic sodium-potassium ATP-ase. Induced opening of such sodium channels may regulate the electrogenic pump activity and indirectly cell activation.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban Amiloride Animal B-Lymphocytes Bretylium Tosylate Calcium Cell Membrane drug effects Dyes Electrochemistry Female Flow Cytometry Fluorescent Dyes Human Lymphocytes Membrane Potentials Mice Mice,Inbred BALB C Mice,Nude pharmacology physiology Potassium Rats Sodium Sodium Channels Support,Non-U.S.Gov't Tetrodotoxin Thiobarbiturates
Megjelenés:	Biochemical and Biophysical Research Communications. - 160 : 3 (1989), p. 999-1002. -
További szerzők:	Recchioni, Rina Moroni, Fausto Balkay László (1963-) (biofizikus) Márián Teréz (1950-) (radiobiológus) Trón Lajos (1941-) (biofizikus) Damjanovich Sándor (1936-2017) (biofizikus)
Internet cím:	elektronikus változat
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