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001-es BibID:BIBFORM039496
Első szerző:Adams, J. N.
Cím:The persistence of hibernating myocardium after acute myocardial infarction / J. N. Adams, R. J. Trent, M. Norton, P. Mikecz, S. Walton, N. Evans
Dátum:1998
ISSN:0195-668X
Megjegyzések:Objective To establish the persistence of hibernating myocardium initially detected after myocardial infarction treated with thrombolysis. Methods and results Fourteen patients underwent gated positron emission tomography with 18-fluoro-deoxyglucose and N13-ammonia at a median of 8 days after first myocardial infarction. Repeat scans were performed at a median of 13 weeks post-infarction. A total of 148 (30·9%) myocardial segments showed reduced N13-ammonia uptake at the time of the first scan compared with 154·5 (32·2%) segments at the time of repeat imaging. The median change in the number of segments with reduced perfusion was -1·0. Initially 13 subjects had hibernating myocardium, seven patients had large areas and six had smaller regions. Six (46·2%) subjects had repeat scans showing unchanged areas of hibernating tissue and seven had second scans demonstrating changes in the size of the region of hibernating myocardium. One patient had no hibernating myocardium on either scan. Conclusions Positron emission tomography performed several months after myocardial infarction demonstrates significant changes in myocardial perfusion. However, a reduction in the number of segments with reduced perfusion does not always result in an improvement in myocardial metabolism and contraction. Whilst most regions of hibernating myocardium were still present several months after infarction, in only approximately half was the size of the mismatched region unchanged. Therefore it is not possible to predict the fate of hibernating myocardium which is present after infarction.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:European Heart Journal. - 19 : 2 (1998), p. 255-262. -
További szerzők:Trent, R. J. Norton, M. Mikecz Pál (1956-) (vegyész) Walton, S. Evans, Noel T. S.
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001-es BibID:BIBFORM046726
035-os BibID:PMID:8665333
Első szerző:Adams, J. N.
Cím:Incidence of hibernating myocardium after acute myocardial infarction treated with thrombolysis / J. N. Adams, M. Norton, R. J. Trent, P. Mikecz, S. Walton, N. Evans
Dátum:1996
ISSN:1355-6037
Megjegyzések:OBJECTIVE: To establish the incidence of hibernating myocardium after myocardial infarction treated with thrombolysis and to observe differences in the clinical outcome between patients with and without hibernating tissue. METHODS: 41 patients underwent gated positron emission tomography with 18-fluorodeoxyglucose and 13N-ammonia at a median of eight days after first myocardial infarction. RESULTS: All 41 subjects had a matched perfusion-metabolism deficit in the region of myocardium indicated as the site of infarction by an electrocardiograph; 32 patients (78%) had scans which also showed at least one area of reduced blood flow and contraction with a concomitant increase in glucose uptake, representing hibernating myocardium. Patients were followed up at a median of six months: all 41 were alive and none had sustained a further infarct or cardiac arrhythmia; 17 subjects with hibernating tissue (53.1%) and two without (25%) reported chest pain after myocardial infarction. CONCLUSIONS: Hibernating myocardium is relatively common shortly after myocardial infarction treated with thrombolysis. It does not influence mortality or the incidence of postinfarction chest pain.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Heart. - 75 : 5 (1996), p. 442-446. -
További szerzők:Norton, M. Trent, R. J. Walton, S. Evans, Noel T. S. Mikecz Pál (1956-) (vegyész)
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3.

001-es BibID:BIBFORM031908
035-os BibID:PMID:7478396
Első szerző:Benyounes, H.
Cím:Superimposition of PET images using 18F-fluorodeoxyglucose with magnetic resonance images in patients with pancreatic carcinoma / Benyounes H., Smith F. W., Campbell C., Evans N. T., Norton M. Y., Mikecz P., Heys S. D., Bruce D., Eremin O., Sharp P. F.
Dátum:1995
ISSN:0143-3636
Megjegyzések:Six patients with histologically proven adenocarcinoma of the pancreas were studied using 2-deoxy-2-[18F]-fluoro-D-glucose (18F-FDG) using positron emission tomography (PET), and magnetic resonance imaging (MRI). In all six cases there was avid accumulation of 18F-FDG within the pancreatic tumour and clear visualization of the tumour on the MRI images. Delineation of the tumours was aided by superimposition of the images from the two imaging methods, which was achieved by using a system of surface markers.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
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Megjelenés:Nuclear Medicine Communications. - 16 : 7 (1995), p. 575-580. -
További szerzők:Smith, Frank W. Campbell, Cabrina Evans, Noel T. S. Norton, M. Heys, S. D. Bruce, D. Eremin, O. Sharp, Peter F. Mikecz Pál (1956-) (vegyész)
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4.

001-es BibID:BIBFORM031909
035-os BibID:PMID:7747223 WOS:A1995QH89400002
Első szerző:Keenan, Gary F.
Cím:Measurement of lower limb blood flow in patients with neurogenic claudication using positron emission tomography / Keenan, Gary F., Ashcroft, George P., Roditi, Giles H., Hutchison, James D., Evans, Noel T. S., Mikecz, Pal, Chaloner, Fiona, Dodd, Maurice, Leonard, Christopher, Porter, Richard W., Sharp, Peter F., Smith, Frank W.
Dátum:1995
ISSN:0362-2436
Megjegyzések:Ten subjects (seven with neurogenic claudication and three control subjects) underwent examination of lower limb muscle blood flow before and after exercise using positron emission tomography. OBJECTIVES: To investigate the hypothesis that lower limb muscle ischemia was the origin of symptoms in neurogenic claudication. BACKGROUND: Patients with neurogenic claudication secondary to spinal stenosis experience lower limb discomfort after exercise similar to that of ischemic claudication. However, they do not have clinical evidence of peripheral vascular disease. The authors postulated that the lower limb discomfort in patients with neurogenic claudication may arise from muscle ischemia due to inadequate dilatation of arterioles in response to exercise, this itself arising secondary to sympathetic dysfunction due to spinal stenosis. METHOD: Using O15-labeled water and positron emission tomography measured thigh and leg muscle blood flow response to exercise bilaterally in seven patients with unilateral neurogenic claudication and three control subjects were measured. RESULTS: The average values obtained for mid-thigh and mid-calf muscle perfusion at rest were 2.57 ml/min/100 g tissue (2.23-3.90) and 2.39 ml/min/100 g tissue (2.03-3.46), respectively. The average values obtained from mid-thigh and mid-calf perfusion after exercise were 4.41 ml/min/100 g tissue (2.8-6.0) and 4.87 ml/min/100 g (2.2-11.7). We found no difference in muscle perfusion between symptomatic and asymptomatic limbs in this group of patients. CONCLUSION: These studies suggest that muscle ischemia is not the origin of symptoms in most patients with neurogenic claudication.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
külföldön készült közlemény
Megjelenés:Spine. - 20 : 4 (1995), p. 408-411. -
További szerzők:Ashcroft, George P. Roditi, Giles H. Hutchison, James D. Evans, Noel T. S. Chaloner, Fiona Dodd, Maurice Leonard, Christopher Porter, Richard W. Sharp, Peter F. Smith, Frank W. Mikecz Pál (1956-) (vegyész)
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