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001-es BibID:	BIBFORM031909
035-os BibID:	PMID:7747223 WOS:A1995QH89400002
Első szerző:	Keenan, Gary F.
Cím:	Measurement of lower limb blood flow in patients with neurogenic claudication using positron emission tomography / Keenan, Gary F., Ashcroft, George P., Roditi, Giles H., Hutchison, James D., Evans, Noel T. S., Mikecz, Pal, Chaloner, Fiona, Dodd, Maurice, Leonard, Christopher, Porter, Richard W., Sharp, Peter F., Smith, Frank W.
Dátum:	1995
ISSN:	0362-2436
Megjegyzések:	Ten subjects (seven with neurogenic claudication and three control subjects) underwent examination of lower limb muscle blood flow before and after exercise using positron emission tomography. OBJECTIVES: To investigate the hypothesis that lower limb muscle ischemia was the origin of symptoms in neurogenic claudication. BACKGROUND: Patients with neurogenic claudication secondary to spinal stenosis experience lower limb discomfort after exercise similar to that of ischemic claudication. However, they do not have clinical evidence of peripheral vascular disease. The authors postulated that the lower limb discomfort in patients with neurogenic claudication may arise from muscle ischemia due to inadequate dilatation of arterioles in response to exercise, this itself arising secondary to sympathetic dysfunction due to spinal stenosis. METHOD: Using O15-labeled water and positron emission tomography measured thigh and leg muscle blood flow response to exercise bilaterally in seven patients with unilateral neurogenic claudication and three control subjects were measured. RESULTS: The average values obtained for mid-thigh and mid-calf muscle perfusion at rest were 2.57 ml/min/100 g tissue (2.23-3.90) and 2.39 ml/min/100 g tissue (2.03-3.46), respectively. The average values obtained from mid-thigh and mid-calf perfusion after exercise were 4.41 ml/min/100 g tissue (2.8-6.0) and 4.87 ml/min/100 g (2.2-11.7). We found no difference in muscle perfusion between symptomatic and asymptomatic limbs in this group of patients. CONCLUSION: These studies suggest that muscle ischemia is not the origin of symptoms in most patients with neurogenic claudication.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban külföldön készült közlemény
Megjelenés:	Spine. - 20 : 4 (1995), p. 408-411. -
További szerzők:	Ashcroft, George P. Roditi, Giles H. Hutchison, James D. Evans, Noel T. S. Chaloner, Fiona Dodd, Maurice Leonard, Christopher Porter, Richard W. Sharp, Peter F. Smith, Frank W. Mikecz Pál (1956-) (vegyész)
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001-es BibID:	BIBFORM031905
035-os BibID:	WOS:000077624500023
Első szerző:	Welch, A. E.
Cím:	Attenuation correction in PET using consistency information / Welch, A., Campbell, C., Clackdoyle, R., Natterer, F., Hudson, M., Bromiley, A., Mikecz, P., Chillcot, F., Dodd, M., Hopwood, P., Craib, S., Gullberg, G. T., Sharp, P.
Dátum:	1998
ISSN:	0018-9499
Megjegyzések:	In this study the authors use the consistency conditions of the Radon transform to aid attenuation correction in PET. The conditions are used both for estimating the parameters of a uniform elliptical attenuation distribution (without any transmission measurements) and for correcting for patient motion between the transmission and emission acquisitions. The results show that, for a uniform elliptical attenuation distribution, the reconstructed count densities obtained using attenuation correction based on the consistency conditions are within 1% of the true values. The method is shown to be fairly tolerant to the effects of photon counting statistics and to small non-uniformities in the attenuation distribution (such as skull attenuation). The results also show that the consistency conditions may be useful in correcting for patient motion. The method is shown to effectively compensate for shifts in two dimensions using both simulated and experimental data
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban külföldön készült közlemény
Megjelenés:	IEEE transactions on nuclear science. - 45 : 6 (1998), p. 3134-3141. -
További szerzők:	Campbell, Cabrina Clackdoyle, R. Natterer, F. Hudson, M. Bromiley, A. Chillcot, F. Dodd, Maurice Hopwood, P. Craib, S. Gullberg, G. T. Sharp, Peter F. Mikecz Pál (1956-) (vegyész)
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