Találati lista | Tudóstér

001-es BibID:	BIBFORM006028
Első szerző:	Damjanovich Sándor (biofizikus)
Cím:	Dynamic physical interactions of plasma membrane molecules generate cell surface patterns and regulate cell activation processes / Damjanovich S., Mátyus L., Balázs, M., Gáspár R., Krasznai Z., Pieri C., Szöllösi J., Trón L.
Dátum:	1992
Megjegyzések:	Molecular interaction and transmembrane signal transducing events generate a very dynamic and ever changing "pattern" in the plasma membranes. Lymphocytes, the key functional elements of the immune system, are eminently suited to be the primary targets to investigate these proximity, mobility, or other physical-chemical changes in their plasma membranes. Recently, a number of experiments suggested that processed peptides from antigens can bind specific components of MHC molecules (Elliott et al., 1991). This is certainly a way to alter their structure. Cell surface patterns of topological nature, assembly and disassembly of oligomeric receptor structure like the IL-2 receptor have been investigated by sophisticated biophysical techniques. The dynamic changes in the two-dimensional cell surface pattern and intramolecular conformational changes within this "larger" macro-pattern may have a strong regulatory role in signal transducing and intercellular recognition processes. Recent data on these problems are presented together with brief and critical discussions.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk Animal Cell Membrane Human Hungary immunology Lymphocyte Transformation Lymphocytes Membrane Proteins Peptides Signal Transduction
Megjelenés:	Immunobiology. - 185 : 2-4 (1992), p. 337-349. -
További szerzők:	Mátyus László (1956-) (biofizikus) Balázs Margit (1952-) (sejtbiológus, molekuláris genetikus) Gáspár Rezső (1944-) (biofizikus) Krasznai Zoltán (1950-) (biofizikus) Pieri, Carlo Szöllősi János (1953-) (biofizikus) Trón Lajos (1941-) (biofizikus)
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változa
Borító:
Saját polcon:

001-es BibID:	BIBFORM002766
Első szerző:	Székely Andrea
Cím:	Nutrition and immune system : certain fatty acids differently modify membrane composition and consequently kinetics of KV1.3 channels of human peripheral lymphocytes/ Szekely A., Kitajka K., Panyi G., Marian T., Gaspar R., Krasznai Z.
Dátum:	2007
Megjegyzések:	Potassium (K(+)) channels of human peripheral lymphocytes play a considerable role in the signalling processes required for immune responses. Modification of the fatty acid composition of the membrane influences the functions of various membrane enzymes and ion channels. We set out to establish how the incorporation of fatty acids with different carbon chain lengths and degrees of unsaturation into the cell membrane influences the function of K(V)1.3 channels of lymphocytes, thereby potentially modifying the immune responses of the cells. The incorporation of the fatty acids into the cell membrane was monitored by gas chromatography. Whole-cell patch-clamp experiments demonstrated that the polyunsaturated linoleic acid, arachidonic acid and docosahexaenoic acid all decreased the activation and inactivation time constants of the K(V)1.3 channels, but did not affect the voltage-dependence of steady-state activation and steady-state inactivation of the channels. Treatment with the saturated palmitic acid, stearic acid and the monounsaturated oleic acid did not result in significant changes in the biophysical parameters of K(V)1.3 gating studied. We conclude that the incorporation of fatty acids unsaturated to different degrees into the cell membrane of lymphocytes influenced the rate of gating transitions but not the equilibrium distribution of the channels between different states. This effect depended on the degree of unsaturation and the chain length of the fatty acids: no effects of saturated and monounsaturated fatty acids (16:0, 18:0 and 18:1) were observed whereas treatment with polyunsaturated fatty acids (18:2, 20:4 and 22:6) resulted in significant changes in the channel kinetics
Tárgyszavak:	Természettudományok Biológiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban Biophysics Cell Membrane Cells chemistry Chromatography Dietary Fats Enzymes Fatty Acids Human Humans Hungary Immune System immunology Ion Channels Kinetics Kv1.3 Potassium Channel Lymphocyte Subsets Lymphocytes metabolism pharmacology physiology Potassium Research Support
Megjelenés:	Immunobiology. - 212 : 3 (2007), p. 213-227. -
További szerzők:	Kitajka Klára Panyi György (1966-) (biofizikus) Márián Teréz (1950-) (radiobiológus) Gáspár Rezső (1944-) (biofizikus) Krasznai Zoltán (1950-) (biofizikus)
Internet cím:	DOI elektronikus változat
Borító:
Saját polcon: