Találati lista | Tudóstér

001-es BibID:	BIBFORM004660
Első szerző:	Farkas Tibor
Cím:	Docosahexaenoic acid-containing phospholipid molecular species in brains of vertebrates / Farkas, T., Kitajka, K., Fodor, E., Csengeri, I., Lahdes, E., Yeo, Y. K., Krasznai, Z., Halver, J. E.
Dátum:	2000
Megjegyzések:	The fatty acid composition of phospholipids and the contents of docosahexaenoic acid (DHA)-containing diacyl phosphatidylcholine and diacyl phosphatidylethanolamine molecular species were determined from brains of five fresh-water fish species from a boreal region adapted to 5 degrees C, five fresh-water fish species from a temperate region acclimated to 5 degrees C, five fresh-water fish species from a temperate region acclimated to 20 degrees C, and three fresh water fish species from a subtropic region adapted to 25-26 degrees C, as well as six mammalian species and seven bird species. There was little difference in DHA levels of fish brains from the different thermal environments; mammalian and bird brain phospholipids contained a few percentage points less DHA than those of the fish investigated. Molecular species of 22:6/22:6, 22:6/20:5, 22:6/20:4, 16:0/22:6, 18:0/22:6, and 18:1/22:6 were identified from all brain probes, and 16:0/22:6, 18:0/22:6, and 18:1/22:6 were the dominating species. Cold-water fish brains were rich in 18:1/22:6 diacyl phosphatidylethanolamine (and, to a lesser degree, in diacyl phosphatidylcholine), and its level decreased with increasing environmental/body temperature. The ratio of 18:0/22:6 to 16:0/22:6 phosphatidylcholine and phosphatidylethanolamine was inversely related to body temperature. Phospholipid vesicles from brains of cold-acclimated fish were more fluid, as assessed by using a 1, 6-diphenyl-1,3,5-hexatriene fluorescent probe, than those from bird brains, but the fluidities were almost equal at the respective body temperatures. It is concluded that the relative amounts of these molecular species and their ratios to each other are the major factors contributing to the maintenance of proper fluidity relationships throughout the evolutionary chain as well as helping to maintain important brain functions such as signal transduction and membrane permeability
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban analysis Animal Birds Body Temperature Brain Brain Chemistry Docosahexaenoic Acids Fatty Acids Fishes Fluorescence Polarization Hungary Membrane Fluidity Phospholipids Research Signal Transduction Support,Non-U.S.Gov't Temperature Water
Megjelenés:	Proceedings of the National Academy of Sciences of the United States of America. - 97 : 12 (2000), p. 6362-6366. -
További szerzők:	Kitajka Klára Fodor Elfrieda Csengeri István Lahdes, Eila Yeo, Young K. Krasznai Zoltán (1950-) (biofizikus) Halver, John E.
Internet cím:	elektronikus változat elektronikus változat
Borító:
Saját polcon:

001-es BibID:	BIBFORM002766
Első szerző:	Székely Andrea
Cím:	Nutrition and immune system : certain fatty acids differently modify membrane composition and consequently kinetics of KV1.3 channels of human peripheral lymphocytes/ Szekely A., Kitajka K., Panyi G., Marian T., Gaspar R., Krasznai Z.
Dátum:	2007
Megjegyzések:	Potassium (K(+)) channels of human peripheral lymphocytes play a considerable role in the signalling processes required for immune responses. Modification of the fatty acid composition of the membrane influences the functions of various membrane enzymes and ion channels. We set out to establish how the incorporation of fatty acids with different carbon chain lengths and degrees of unsaturation into the cell membrane influences the function of K(V)1.3 channels of lymphocytes, thereby potentially modifying the immune responses of the cells. The incorporation of the fatty acids into the cell membrane was monitored by gas chromatography. Whole-cell patch-clamp experiments demonstrated that the polyunsaturated linoleic acid, arachidonic acid and docosahexaenoic acid all decreased the activation and inactivation time constants of the K(V)1.3 channels, but did not affect the voltage-dependence of steady-state activation and steady-state inactivation of the channels. Treatment with the saturated palmitic acid, stearic acid and the monounsaturated oleic acid did not result in significant changes in the biophysical parameters of K(V)1.3 gating studied. We conclude that the incorporation of fatty acids unsaturated to different degrees into the cell membrane of lymphocytes influenced the rate of gating transitions but not the equilibrium distribution of the channels between different states. This effect depended on the degree of unsaturation and the chain length of the fatty acids: no effects of saturated and monounsaturated fatty acids (16:0, 18:0 and 18:1) were observed whereas treatment with polyunsaturated fatty acids (18:2, 20:4 and 22:6) resulted in significant changes in the channel kinetics
Tárgyszavak:	Természettudományok Biológiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban Biophysics Cell Membrane Cells chemistry Chromatography Dietary Fats Enzymes Fatty Acids Human Humans Hungary Immune System immunology Ion Channels Kinetics Kv1.3 Potassium Channel Lymphocyte Subsets Lymphocytes metabolism pharmacology physiology Potassium Research Support
Megjelenés:	Immunobiology. - 212 : 3 (2007), p. 213-227. -
További szerzők:	Kitajka Klára Panyi György (1966-) (biofizikus) Márián Teréz (1950-) (radiobiológus) Gáspár Rezső (1944-) (biofizikus) Krasznai Zoltán (1950-) (biofizikus)
Internet cím:	DOI elektronikus változat
Borító:
Saját polcon: