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001-es BibID:	BIBFORM006028
Első szerző:	Damjanovich Sándor (biofizikus)
Cím:	Dynamic physical interactions of plasma membrane molecules generate cell surface patterns and regulate cell activation processes / Damjanovich S., Mátyus L., Balázs, M., Gáspár R., Krasznai Z., Pieri C., Szöllösi J., Trón L.
Dátum:	1992
Megjegyzések:	Molecular interaction and transmembrane signal transducing events generate a very dynamic and ever changing "pattern" in the plasma membranes. Lymphocytes, the key functional elements of the immune system, are eminently suited to be the primary targets to investigate these proximity, mobility, or other physical-chemical changes in their plasma membranes. Recently, a number of experiments suggested that processed peptides from antigens can bind specific components of MHC molecules (Elliott et al., 1991). This is certainly a way to alter their structure. Cell surface patterns of topological nature, assembly and disassembly of oligomeric receptor structure like the IL-2 receptor have been investigated by sophisticated biophysical techniques. The dynamic changes in the two-dimensional cell surface pattern and intramolecular conformational changes within this "larger" macro-pattern may have a strong regulatory role in signal transducing and intercellular recognition processes. Recent data on these problems are presented together with brief and critical discussions.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk Animal Cell Membrane Human Hungary immunology Lymphocyte Transformation Lymphocytes Membrane Proteins Peptides Signal Transduction
Megjelenés:	Immunobiology. - 185 : 2-4 (1992), p. 337-349. -
További szerzők:	Mátyus László (1956-) (biofizikus) Balázs Margit (1952-) (sejtbiológus, molekuláris genetikus) Gáspár Rezső (1944-) (biofizikus) Krasznai Zoltán (1950-) (biofizikus) Pieri, Carlo Szöllősi János (1953-) (biofizikus) Trón Lajos (1941-) (biofizikus)
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változa
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001-es BibID:	BIBFORM004645
035-os BibID:	(scopus)0033552675 (wos)000084290400003
Első szerző:	Damjanovich Sándor (biofizikus)
Cím:	Two-dimensional receptor patterns in the plasma membrane of cells : a critical evaluation of their identification, origin and information content / Damjanovich, S., Bene, L., Matko, J., Matyus, L., Krasznai, Z., Szabo, G., Pieri, C., Gaspar, R., Szollosi, J.
Dátum:	1999
Megjegyzések:	A concise review is presented on the nature, possible origin and functional significance of cell surface receptor patterns in the plasma membrane of lymphoid cells. A special emphasize has been laid on the available methodological approaches, their individual virtues and sources of errors. Fluorescence energy transfer is one of the oldest available means for studying non-randomized co-distribution patterns of cell surface receptors. A detailed and critical description is given on the generation of two-dimensional cell surface receptor patterns based on pair-wise energy transfer measurements. A second hierarchical-level of receptor clusters have been described by electron and scanning force microscopies after immuno-gold-labeling of distinct receptor kinds. The origin of these receptor islands at a nanometer scale and island groups at a higher hierarchical (mum) level, has been explained mostly by detergent insoluble glycolipid-enriched complexes known as rafts, or detergent insoluble glycolipids (DIGs). These rafts are the most-likely organizational forces behind at least some kind of receptor clustering [K. Simons et al., Nature 387 (1997) 569]. These models, which have great significance in trans-membrane signaling and intra-membrane and intracellular trafficking, are accentuating the necessity to revisit the Singer-Nicolson fluid mosaic membrane model and substitute the free protein diffusion with a restricted diffusion concept.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk Biophysics Cells Diffusion Energy Transfer Fluorescence Hungary Microscopy
Megjelenés:	Biophysical Chemistry. - 82 : 2-3 (1999), p. 99-108. -
További szerzők:	Bene László (1963-) (biofizikus) Matkó János (1952-) (biológus) Mátyus László (1956-) (biofizikus) Krasznai Zoltán (1950-) (biofizikus) Szabó Gábor (1953-) (biofizikus) Pieri, Carlo Gáspár Rezső (1944-) (biofizikus) Szöllősi János (1953-) (biofizikus)
Internet cím:	DOI elektronikus változat
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001-es BibID:	BIBFORM004688
Első szerző:	Panyi György (biofizikus)
Cím:	Electrophysiology of human lymphocytes / Panyi, G., Gaspar, R., Krasznai, Z., Matyus, L., Van Duijn, B.
Dátum:	2001
ISSN:	90-8-2521-9-0
Tárgyszavak:	Orvostudományok Elméleti orvostudományok könyvfejezet Electrophysiology Human
Megjelenés:	Molecular and Cell Biology: from plant to human. - p. 162-183.
További szerzők:	Gáspár Rezső (1944-) (biofizikus) Krasznai Zoltán (1950-) (biofizikus) Mátyus László (1956-) (biofizikus) Duijn, B., Van
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001-es BibID:	BIBFORM006052
Első szerző:	Pieri, Carlo
Cím:	A sodium channel opener inhibits stimulation of human peripheral blood mononuclear cells / Pieri, C., Recchioni, R., Moroni, F., Marcheselli, F., Falasca, M., Krasznai, Z., Gaspar, R., Matyus, L., Damjanovich, S.
Dátum:	1992
Megjegyzések:	The role of membrane potential changes in T cell activation was studied on human peripheral blood lymphocytes stimulated with phytohemagglutinin. Addition of bretylium tosylate, a sodium channels opener, to PHA treated lymphocytes modified the membrane potential and consequently blocked cell activation in a dose-dependent fashion. BT was non-toxic even in long-term (72 hr) incubations. It was reversibly removable, and the removal restored the stimulatory effect of PHA. 3H-thymidine incorporation was blocked if BT was present during the first 20-24 hr of the mitogenic activation. The later BT was added after PHA, the less inhibition of proliferation was observed. BT hyperpolarized the lymphocytes also in the presence of PHA. BT hindered the depolarizing effect of high extracellular potassium concns. The sustained polarized state of the lymphocytes did not influence the intracellular calcium increase upon PHA treatment. IL-2 and transferrin receptor expression was not hindered by BT during PHA stimulation of lymphocytes. Addition of rIL-2 did not abolish the inhibitory effect of BT. According to cell-cycle analysis BT arrested the majority of the cells in G1 phase. It is suggested that cell activation demands the flexible maintenance of a relatively narrow membrane potential "window". Any sustained and significant hyper-, or depolarization, may dramatically decrease the effectivity of transmembrane signalling.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban analysis blood Bretylium Tosylate Calcium Cell Cycle cytology Dose-Response Relationship,Drug drug effects Flow Cytometry Human In Vitro Interleukin-2 Lymphocyte Transformation Lymphocytes Membrane Potentials pharmacology physiology Phytohemagglutinins Potassium Receptors,Transferrin Research Sodium Sodium Channels Support,Non-U.S.Gov't T-Lymphocytes
Megjelenés:	Molecular Immunology. - 29 : 4 (1992), p. 517-524. -
További szerzők:	Recchioni, Rina Moroni, Fausto Marcheselli, Fiorella Falasca, Marco Krasznai Zoltán (1950-) (biofizikus) Gáspár Rezső (1944-) (biofizikus) Mátyus László (1956-) (biofizikus) Damjanovich Sándor (1936-2017) (biofizikus)
Internet cím:	elektronikus változat Intézményi repozitóriumban (DEA) tárolt változa
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