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001-es BibID:	BIBFORM040240
Első szerző:	Márton K.
Cím:	Evaluation of palatal saliva flow rate and oral manifestations in patients with Sjogren's syndrome / Márton K., Boros I., Varga G., Zelles T., Fejérdy P., Zeher M., Nagy G.
Dátum:	2006
ISSN:	1354-523X
Megjegyzések:	OBJECTIVE: The purpose of this study was to describe the oral properties of Sjögren's syndrome (SS), including the determination of palatal saliva (PS) flow rate. SUBJECTS AND METHODS: Forty-nine SS patients and 43 healthy controls participated. Subjective symptoms were recorded and clinical assessments of the oral mucosal, dental and periodontal status were made. Unstimulated whole saliva (WS) and PS flow rates, the number of decayed, missing and filled teeth (DMF-T number), the gingival bleeding index (GBI) and the periodontal probing depth (PPD) were determined. RESULTS: Despite the decrease in the flow rate of WS in SS patients, PS was not different from those of the controls (1.57 +/- 1.02 and 1.35 +/- 2.5 microl cm(-2) min(-1), respectively). GBI (20.0% vs. 10.5%, respectively), DMF-T (27.1 +/- 6.12 vs. 23.0 +/- 6.99, respectively) and PPD (2.28 +/- 1.09 mm vs. 1.82 +/- 0.73 mm, respectively) were higher in SS compared with the controls (P < 0.05). DMF-T and PPD showed a positive correlation with anti-SSA and/or anti-SSB antibody positivity in the serum (P < 0.05). CONCLUSIONS: Data of the present study suggest that the subjective feeling of xerostomia in SS patients is the result of a decrease in the volume of the whole saliva, and not of the viscous PS. Correlation of DMF-T and PPD with autoantibody positivity reveals that the oral health status of SS patients may be associated with the general autoimmune process.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	Oral Diseases. - 12 : 5 (2006), p. 480-486. -
További szerzők:	Boros István Varga G. Zelles Tivadar Fejérdy P. (Budapest) Zeher Margit (1957-2018) (belgyógyász, allergológus és klinikai immunológus, reumatológus) Nagy G. (Budapest)
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001-es BibID:	BIBFORM017912
Első szerző:	Mészáros T. (Budapest)
Cím:	C1-inhibitor autoantibodies in SLE. / Mészáros T., Füst G., Farkas H., Jakab L., Temesszentandrási G., Nagy G., Kiss E., Gergely P., Zeher M., Griger Z., Czirják L., Hóbor R., Haris A., Polner K., Varga L.
Dátum:	2010
ISSN:	0961-2033
Megjegyzések:	The presence of anti-C1-inhibitor (anti-C1-INH) autoantibodies is a hallmark of acquired C1-inhibitor deficiency. However, only scarce data are available on their prevalence, diagnostic value, and/or significance in systemic lupus erythematosus (SLE). In a multicentre study, we determined the levels of autoantibodies to C1-inhibitor in sera from 202 patients with SLE and 134 healthy controls. Additional clinical and laboratory parameters, such as organ involvement, as well as anti-C1q, anti-double-stranded DNA antibody, erythrocyte sedimentation rate, C-reactive protein, C3 and C4 serum complement levels have been studied in patients. The level of anti-C1-INH IgG was significantly higher (p = 0.034) in SLE patients, than in the controls. A high anti-C1-INH level of > or =0.4 U/ml (mean of controls + 2 SD) was found in 17% of the patients, but in only 4% of the controls (p = 0.0003). The SLEDAI score was significantly higher (p = 0.048) and the duration of SLE was significantly longer (p = 0.0004) among patients with elevated anti-C1-INH levels compared with patients without this autoantibody (median disease duration 8 vs. 17 years, respectively). Anti-C1-INH level was not correlated with any other laboratory parameter or organ manifestation of the disease. These findings indicate that the anti-C1-INH level is higher in SLE patients than in healthy controls and furthermore, the anti-C1-INH level correlates with the duration and activity of the disease.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	Lupus 19 : 5 (2010), p. 634-638. -
További szerzők:	Füst György (Budapest) Farkas H. (Budapest) Jakab Lajos (Budapest) Temesszentandrási G. (Budapest) Nagy G. (Budapest) Kiss Emese (Budapest) Gergely Péter (Budapest) Zeher Margit (1957-2018) (belgyógyász, allergológus és klinikai immunológus, reumatológus) Griger Zoltán (1979-) (belgyógyász, allergológus és klinikai immunológus, reumatológus) Czirják László Hóbor Renáta Haris A. (Budapest) Polner Kálmán Varga L. (Budapest)
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