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001-es BibID:BIBFORM062133
Első szerző:Péter Andrea (kardiológus)
Cím:Echocardiographic abnormalities in new-onset polymyositis/dermatomyositis / Andrea Péter, Ágnes Balogh, Szabolcs Szilágyi, Réka Faludi, Melinda Nagy-Vincze, István Édes, Katalin Dankó
Dátum:2015
Megjegyzések:OBJECTIVE:To identify early echocardiographic abnormalities at the time of diagnosis of polymyositis (PM) and dermatomyositis (DM) and follow the echocardiographic findings during the first 3 months of therapy.METHODS:We included 30 PM/DM patients (23/7) with a mean age of 42.3 ? 1.6 years and without cardiovascular symptoms. Age-matched healthy patients served as controls. Clinical characteristics were recorded. Traditional echocardiography and tissue Doppler imaging (TDI) were performed to measure systolic [ejection fraction, right ventricular fractional area change (RV FAC), lateral and tricuspid annulus s velocities] and diastolic echocardiographic variables (mitral inflow velocities: E, A; deceleration time: DT; lateral and tricuspid annulus e', a' velocities, lateral E/e').RESULTS:The left and right ventricular systolic dysfunction detected by TDI at the time of the PM/DM diagnosis improved, and characteristic values at the end of the followup period were comparable to those of the controls (lateral s: 10.6 ? 0.2, 8.7 ? 0.4, 9.6 ? 0.3, 11.3 ? 0.2 cm/s; RV FAC: 45.2 ? 2.3, 36.9 ? 1.5, 42.2 ? 1.3, 46.9 ? 1.2%; tricuspid s: 13.3 ? 0.2, 9.5 ? 0.4, 10.3 ? 0.3, 11.6 ? 0.5 cm/s; control, 0, 1, and 3 mos, respectively). Measurements indicated the development of diastolic dysfunction at 3 mos (E/A: 1.4 ? 0.1, 1.29 ? 0.05, 1.03 ? 0.05, 0.92 ? 0.05; DT: 148.6 ? 3.6, 157.3 ? 5.7, 168.3 ? 6.0, 184.3 ? 6.2 ms; lateral e': 12.8 ? 0.3, 12.1 ? 0.5, 10.2 ? 0.6, 10.8 ? 0.8 cm/s; E/e': 5.6 ? 0.1, 5.0 ? 0.22, 6.92 ? 0.46, 7.64 ? 0.47; control, 0, 1, and 3 mos, respectively).CONCLUSION:TDI is a useful method to detect early cardiac abnormalities complementing the conventional echocardiographic measurements. LV and RV systolic dysfunction found in the acute phase significantly improved during the first 3 months of therapy; however, deterioration of diastolic dysfunction was also observed.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
DERMATOMYOSITIS
ECHOCARDIOGRAPHY
POLYMYOSITIS
SYSTOLIC AND DIASTOLIC DYSFUNCTION
TISSUE DOPPLER IMAGING
Megjelenés:The Journal of rheumatology. - 42 : 2 (2015), p. 272-281. -
További szerzők:Balogh Ágnes (1984-) (kardiológus) Szilágyi Szabolcs (1976-) (kardiológus) Faludi Réka Nagy-Vincze Melinda (1985-) (orvos) Édes István (1952-) (kardiológus) Dankó Katalin (1952-2021) (belgyógyász, allergológus és klinikai immunológus)
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