Magyar
Toggle navigation
Tudóstér
Magyar
Tudóstér
Keresés
Egyszerű keresés
Összetett keresés
CCL keresés
Egyszerű keresés
Összetett keresés
CCL keresés
Böngészés
Saját polc tartalma
(
0
)
Korábbi keresések
CCL parancs
CCL
Összesen 1 találat.
#/oldal:
12
36
60
120
Rövid
Hosszú
MARC
Részletezés:
Rendezés:
Szerző növekvő
Szerző csökkenő
Cím növekvő
Cím csökkenő
Dátum növekvő
Dátum csökkenő
1.
001-es BibID:
BIBFORM073197
Első szerző:
Rider, Lisa G.
Cím:
2016 ACR-EULAR adult dermatomyositis and polymyositis and juvenile dermatomyositis response criteria-methodological aspects / Lisa G. Rider, Nicolino Ruperto, Angela Pistorio, Brian Erman, Nastaran Bayat, Peter A. Lachenbruch, Howard Rockette, Brian M. Feldman, Adam M. Huber, Paul Hansen, Chester V. Oddis, Ingrid E. Lundberg, Anthony A. Amato, Hector Chinoy, Robert G. Cooper, Lorinda Chung, Katalin Danko, David Fiorentino, Ignacio García-De la Torre, Ann M. Reed, Yeong Wook Song, Rolando Cimaz, Rubén J. Cuttica, Clarissa A. Pilkington, Alberto Martini, Janjaap van der Net, Susan Maillard, Frederick W. Miller, Jiri Vencovsky, Rohit Aggarwal, International Myositis Assessment and Clinical Studies Group, Paediatric Rheumatology International Trials Organisation
Dátum:
2017
ISSN:
1462-0324
Megjegyzések:
OBJECTIVE:The objective was to describe the methodology used to develop new response criteria for adult DM/PM and JDM.METHODS:Patient profiles from prospective natural history data and clinical trials were rated by myositis specialists to develop consensus gold-standard ratings of minimal, moderate and major improvement. Experts completed a survey regarding clinically meaningful improvement in the core set measures (CSM) and a conjoint-analysis survey (using 1000Minds software) to derive relative weights of CSM and candidate definitions. Six types of candidate definitions for response criteria were derived using survey results, logistic regression, conjoint analysis, application of conjoint-analysis weights to CSM and published definitions. Sensitivity, specificity and area under the curve were defined for candidate criteria using consensus patient profile data, and selected definitions were validated using clinical trial data.RESULTS:Myositis specialists defined the degree of clinically meaningful improvement in CSM for minimal, moderate and major improvement. The conjoint-analysis survey established the relative weights of CSM, with muscle strength and Physician Global Activity as most important. Many candidate definitions showed excellent sensitivity, specificity and area under the curve in the consensus profiles. Trial validation showed that a number of candidate criteria differentiated between treatment groups. Top candidate criteria definitions were presented at the consensus conference.CONCLUSION:Consensus methodology, with definitions tested on patient profiles and validated using clinical trials, led to 18 definitions for adult PM/DM and 14 for JDM as excellent candidates for consideration in the final consensus on new response criteria for myositis.
Tárgyszavak:
Orvostudományok
Klinikai orvostudományok
idegen nyelvű folyóiratközlemény külföldi lapban
1000Minds software
conjoint analysis
dermatomyositis
hybrid measure
juvenile dermatomyositis
outcome assessment
polymyositis
response criteria
Megjelenés:
Rheumatology 56 : 11 (2017), p. 1884-1893. -
További szerzők:
Ruperto, Nicolino
Pistorio, Angela
Erman, Brian
Bayat, Nastaran
Lachenbruch, Peter A.
Rockette, Howard
Feldman, Brian M.
Huber, Adam M.
Hansen, Paul
Oddis, Chester V.
Lundberg, Ingrid
Amato, Anthony A.
Chinoy, Hector
Cooper, Robert G.
Chung, Lorinda
Dankó Katalin (1952-2021) (belgyógyász, allergológus és klinikai immunológus)
Fiorentino, David
Torre, Ignacio García-De la
Reed, Ann M.
Song, Yeong Wook
Cimaz, Rolando
Cuttica, Ruben
Pilkington, Clarissa
Martini, Alberto
Net, Janjaap van der
Maillard, Susan
Miller, Frederick W.
Vencovsky, Jiri
Aggarwal, Rohit
International Myositis Assessment and Clinical Studies Group
Paediatric Rheumatology International Trials Organisation (PRINTO)
Internet cím:
Szerző által megadott URL
DOI
Intézményi repozitóriumban (DEA) tárolt változat
Borító:
Saját polcon:
Rekordok letöltése
1
Corvina könyvtári katalógus v8.2.27
© 2023
Monguz kft.
Minden jog fenntartva.