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001-es BibID:	BIBFORM036287
035-os BibID:	PMID:16795968
Első szerző:	Altorjay Áron
Cím:	Morphological changes in the lower esophageal sphincter influencing the result of antireflux surgical interventions in chronic gastroesophageal reflux disease / Áron Altorjay, Anna Szilagyi, Gabriella Arato, Balazs Paal, Arpad Juhasz, Gábor Kecskes, István Altorjay, János Kiss, Pal Nagy
Dátum:	2006
ISSN:	0172-6390
Megjegyzések:	BACKGROUND/AIMS: It is still unclear whether long-term reflux episodes result in morphological changes in the lower esophageal sphincter or not. If the answer is supposedly yes, do these changes influence the postoperative functional results following antireflux surgery? METHODOLOGY: Between 1 January 2002 and 2004, we performed antireflux surgery on 85 patients. Muscle samples were taken from the lower esophageal sphincter (LES) in 57 patients on operation. Patients with endoscopic findings of moderate or severe reflux esophagitis--Los Angeles B, C, D--were excluded. Control samples were obtained from muscle tissue at the gastroesophageal junction that had been removed from 16 patients undergoing gastric or esophageal resection. Histologic (hematoxylin and eosin and Giemsa), and immunohistologic (S-100 Protein, NCL-SERCA2, alpha-SMA) and electronmicroscopic analysis were used to evaluate the specimens. The number of smooth muscle cell nuclei in these intraoperative biopsies was used to compare the results of antireflux operations (Visick I and II-III). RESULTS: In 19% (11/57) of the reflux-type LES muscle samples perivascular inflammatory infiltration has been noted and in 6 of these cases (6/57 = 11%) this has incorporated marked intramuscular and adventitial granulocyte infiltration. In one patient (1/57 = 2%) eosinophil infiltration of the myenteric plexus and the ganglion has been revealed. Significantly lower Schwann and smooth muscle cell count could be detected in LES muscle samples taken from patients with GERD (p < 0.05). The analysis of the values of the 9 patients in Visick groups II and III at two months after surgery, has shown a significant decrease in the number of smooth muscle cell nuclei as compared to those patients in Visick group I (p < 0.01). CONCLUSIONS: Our results draw attention to the morphological changes occurring in the LES muscles of reflux patients. The enteric ganglionitis induced by GERD may result in various functional esophageal diseases. The histologic changes--that very much resemble hypertrophy--developing in LES muscles may serve as a reason for symptoms after antireflux surgery, presumably for the most common complaint of dysphagia.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban egyetemen (Magyarországon) készült közlemény
Megjelenés:	Hepato-Gastroenterology 53 : 69 (2006), p. 342-347. -
További szerzők:	Szilágyi Anna Tünde (1981-) Arató Gabriella Paál Balázs Juhász Árpád Kecskés Gábor Altorjay István (1954-) (belgyógyász, gasztroenterológus, onkológus) Kiss János (sebész) Nagy Pál (patológus)
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM019278
Első szerző:	Kerekes László (sebész, háziorvos)
Cím:	Evaluation of hemostatic changes and blood antioxidant capacity in acute and chronic pancreatitis / Kerekes László, Árkossy Péter, Altorjay István, Huszka Mariann, Kappelmayer János, Tóth Péter, Szentkereszty Zsolt, Sápy Péter
Dátum:	2001
ISSN:	0172-6390
Megjegyzések:	We examined changes in hemostasis, in levels of total antioxidant capacity, and pancreatic enzymes (amylase, lipase) in patients with pancreatitis 1, 3 and 7 days after admission to the clinic, in order to evaluate the inflammatory processes in acute and chronic pancreatitis and to identify new prognostic markers. METHODOLOGY: The rate of CD62 expression--a marker of platelet hyperactivity--and the rate of platelet-leukocyte aggregates were measured by flow cytometry. The connection between the parameters measured and the severity of pancreatitis and also the differences of the parameters in acute and chronic pancreatitis were investigated. RESULTS: On the basis of previous studies it was assumed, that there is a connection between the level of parameters measured and the inflammatory process in the pancreas, and also between the defending processes of the body against free radicals. CONCLUSIONS: Based on our results, we suggest to extend the laboratory measurements to the investigation of hemostatic parameters. The measurement of plasma level of fibrinogen, von Willebrand factor and the rate of platelet activation is especially important.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	Hepato-Gastroenterology. - 48 : 42 (2001), p. 1746-1749. -
További szerzők:	Árkosy Péter (1962-) (általános sebész, mellkassebész) Altorjay István (1954-) (belgyógyász, gasztroenterológus, onkológus) Huszka Mariann Kappelmayer János (1960-) (laboratóriumi szakorvos) Tóth Péter (sebész) Szentkereszty Zsolt (1961-) (sebész) Sápy Péter (1942-) (sebész)
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM036298
035-os BibID:	PMID:15966211
Első szerző:	Lakatos Péter (Semmelweis Egyetem)
Cím:	Clinical presentation of Crohn's disease : association between familial disease, smoking, disease phenotype, extraintestinal manifestations and need for surgery / Peter Laszlo Lakatos, Ferenc Szalay, Zsolt Tulassay, Tamas Molnar, Agota Kovacs, Beata Gasztonyi, Janos Papp, the Hungarian IBD Study Group, Laszlo Lakatos
Dátum:	2005
ISSN:	0172-6390
Megjegyzések:	Recent molecular data suggest that genetic factors may underlie the disease heterogeneity observed in Crohn's disease (CD). It was also suggested that familial inflammatory bowel disease (IBD) is a homogenous subgroup, phenotypically different from sporadic disease. Our aim was to determine the clinical presentation in a large CD population. METHODOLOGY: 564 CD patients (m/f: 278/286, age: 37.4 (SD 12.7) yrs, duration: 8.4 (7.1) yrs) were included. Disease phenotype was determined according to Vienna classification. Familial disease, extraintestinal manifestations (EIM), need for surgery and smoking habits were also analyzed. RESULTS: Familial IBD was present in 73 (12.9%) patients. Age at onset and presence of EIMs was associated with familial disease. Penetrating (44.6% vs. <10 yrs: 29.1%, P<0.0001) and ileocolonic disease (54.4% vs. 42.8%, P=0.03) were more common in patients with a disease duration of > or =10 yrs. In a logistic regression model female gender, colonic/ileocolonic location, smoking and familial IBD were independent risk factors for EIMs, while ileal and non-inflammatory disease increased the risk for resections. Smoking was also associated with frequent relapses. CONCLUSIONS: Familial IBD was associated with the presence of EIMs, while ileal involvement and noninflammatory behavior independently increased the risk for surgery. Since penetrating and extensive disease was more frequent in patients with longer disease duration our data support a possible change in location and behavior during the course of disease.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban egyetemen (Magyarországon) készült közlemény
Megjelenés:	Hepato-Gastroenterology. - 52 : 63 (2005), p. 817-822. -
További szerzők:	Szalay Ferenc (belgyógyász) Tulassay Zsolt (1944-) (belgyógyász, gasztroenterológus) Molnár Tamás (orvos Szeged) Kovács Ágota Gasztonyi Beáta Papp János (Budapest) Lakatos László (Veszprém) Altorjay István (1954-) (belgyógyász, gasztroenterológus, onkológus) The Hungarian IBD Study Group
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat
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