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1.

001-es BibID:BIBFORM013679
Első szerző:Altorjay István (belgyógyász, gasztroenterológus, onkológus)
Cím:Mannose-binding lectin deficiency confers risk for bacterial infections in a large Hungarian cohort of patients with liver cirrhosis / Altorjay Istvan, Vitalis Zsuzsanna, Tornai Istvan, Palatka Karoly, Kacska Sandor, Farkas Gyula, Udvardy Miklos, Harsfalvi Jolan, Dinya Tamas, Orosz Peter, Lombay Bela Jr., Par Gabriella, Par Alajos, Csak Timea, Osztovits Janos, Szalay Ferenc, Csepregi Antal, Lakatos Peter Laszlo, Papp Maria
Dátum:2010
ISSN:0168-8278
Megjegyzések:Mannose-binding lectin (MBL) is a serum lectin synthesized by the liver and involved in innate host defense. MBL deficiency increases the risk of various infectious diseases mostly in immune-deficient conditions. Bacterial infections are a significant cause of morbidity and mortality in liver cirrhosis due to the relative immuncompromised state. Methods: Sera of 929 patients with various chronic liver diseases[autoimmune liver diseases (ALD), 406; viral hepatitis C (HCV), 185; and liver cirrhosis (LC) with various etiologies, 338] and 296 healthy controls (HC) were assayed for MBL concentration. Furthermore, a follow-up, observational study was conducted to assess MBL level as a risk factor for clinically significant bacterial infections in cirrhotic patients. Results:MBL level and the prevalence of absolute MBL deficiency (<100 ng/ml) was not significantly different between patients and controls (ALD: 14.5%, HCV: 11.9%, LC: 10.7%, HC: 15.6%). In cirrhotic patients, the risk for infection was significantly higher among MBL deficient subjects as compared to non-deficient ones (50.0% vs. 31.8%, p = 0.039). In a logistic regression analysis, MBL deficiency was an independent risk factor for infections (OR: 2.14 95% CI: 1.03?4.45, p = 0.04) after adjusting for Child?Pugh score, co-morbidities, gender, and age. In a Kaplan?Meier analysis, MBL deficiency was associated with a shorter time to develop the first infectious complication (median days: 579 vs. 944, pBreslow = 0.016, pLogRank = 0.027) and was identified as an independent predictor in a multivariate Cox-regression analysis (p = 0.003, OR: 2.33, 95% CI: 1.34?4.03). Conclusions:MBL deficiency is associated with a higher probability and shorter time of developing infections in liver cirrhosis, further supporting the impact of the MBL molecule on the host defense.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Mannose-binding lectin
Chronic liver diseases
Liver cirrhosis
Bacterial infection
egyetemen (Magyarországon) készült közlemény
Megjelenés:Journal of Hepatology. - 53 : 3 (2010), p. 484-491. -
További szerzők:Vitális Zsuzsanna (1963-) (belgyógyász, gasztroenterológus) Tornai István (1954-) (belgyógyász, gasztroenterológus) Palatka Károly (1961-) (belgyógyász, gasztroenterológus) Kacska Sándor (1975-) (belgyógyász) Farkas Gyula Udvardy Miklós (1947-) (belgyógyász, haematológus) Hársfalvi Jolán (1949-) (klinikai biokémikus) Dinya Tamás (1974-) (sebész szakorvos, onkológus szakorvos) Orosz Péter (Miskolc) Lombay Béla Jr. Pár Gabriella Pár Alajos Csak Timea Osztovits János Szalay Ferenc (belgyógyász) Csepregi Antal Lakatos Péter (Semmelweis Egyetem) Papp Mária (1975-) (belgyógyász, gasztroenterológus)
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DOI
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2.

001-es BibID:BIBFORM036300
035-os BibID:PMID:15770725
Első szerző:Lakatos Péter (Semmelweis Egyetem)
Cím:Toll-like receptor 4 and NOD2/CARD15 mutations in Hungarian patients with Crohn's disease : phenotype-genotype correlations / Peter Laszlo Lakatos, Laszlo Lakatos, Ferenc Szalay, Claudia Willheim-Polli, Christoph Österreicher, Zsolt Tulassay, Tamas Molnar, Walter Reinisch, Janos Papp, Gyula Mozsik, Peter Ferenci, The Hungarian IBD Study Group
Dátum:2005
Megjegyzések:AIM: To determine common NOD2/CARD15 mutations and TLR4 D299G polymorphism in Hungarian patients with CD. METHODS: A total of 527 unrelated patients with CD (male/female: 265/262, age: 37.1 (SD 7.6) years) and 200 healthy subjects were included. DNA was screened for possible NOD2/CARD15 mutations by denaturing high-performance liquid chromatography (confirmed by direct sequencing). TLR4 D299G was tested by PCR-RFLP. RESULTS: NOD2/CARD15 mutations were found in 185 patients (35.1%) and in 33 controls (16.5%, P<0.0001). SNP8/R702W (10.8% vs 6%, P = 0.02), SNP13/3020insC (19.4% vs 5%, P<0.0001) and exon4 R703C (2.1% vs 0%, P = 0.02) mutations were more frequent in CD, while the frequency of SNP12/G908R was not increased. The frequency of TLR4 D299G was not different (CD: 9.9% vs controls: 12.0%). Variant NOD2/CARD15 allele was associated with an increased risk for CD (OR(het) = 1.71, 95%CI = 1.12-2.6, P = 0.0001, OR(two-risk alleles) = 25.2, 95%CI = 4.37-8, P<0.0001), early disease onset (carrier: 26.4 years vs non-carrier: 29.8 years, P = 0.0006), ileal disease (81.9% vs 69.5%, OR = 1.99, 95%CI = 1.29-3.08, P = 0.02, presence of NOD2/CARD15 and TLR4: 86.7% vs 64.8%), stricturing behavior (OR = 1.69, 95%CI = 1.13-2.55, P = 0.026) and increased need for resection (OR=1.71, 95%CI: 1.13-2.62, P = 0.01), but not with duration, extra-intestinal manifestations, familial disease or smoking. TLR4 exhibited a modifier effect: age of onset in wt/TLR4 D299G carriers: 27.4 years vs NOD2mut/TLR D299G: 23 years (P = 0.06), in NOD2mut/wt: 26.7 years. CONCLUSION: These results confirm that variant NOD2/CARD15 (R702W, R703C and 3020insC) alleles are associated with earlier disease onset, ileal disease, stricturing disease behavior in Hungarian CD patients. In contrast, although the frequency of TLR4 D299G polymorphism was not different from controls, NOD2/TLR4 mutation carriers tended to present at earlier age.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
egyetemen (Magyarországon) készült közlemény
Megjelenés:World Journal of Gastroenterology. - 11 : 10 (2005), p. 1489-1495. -
További szerzők:Lakatos László (Veszprém) Szalay Ferenc (belgyógyász) Willheim-Polli, Claudia Österreicher, Christoph Tulassay Zsolt (1944-) (belgyógyász, gasztroenterológus) Molnár Tamás (orvos Szeged) Reinisch, Walter Papp János (Budapest) Mózsik Gyula Ferenci Péter Altorjay István (1954-) (belgyógyász, gasztroenterológus, onkológus) The Hungarian IBD Study Group
Internet cím:Intézményi repozitóriumban (DEA) tárolt változat
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3.

001-es BibID:BIBFORM036298
035-os BibID:PMID:15966211
Első szerző:Lakatos Péter (Semmelweis Egyetem)
Cím:Clinical presentation of Crohn's disease : association between familial disease, smoking, disease phenotype, extraintestinal manifestations and need for surgery / Peter Laszlo Lakatos, Ferenc Szalay, Zsolt Tulassay, Tamas Molnar, Agota Kovacs, Beata Gasztonyi, Janos Papp, the Hungarian IBD Study Group, Laszlo Lakatos
Dátum:2005
ISSN:0172-6390
Megjegyzések:Recent molecular data suggest that genetic factors may underlie the disease heterogeneity observed in Crohn's disease (CD). It was also suggested that familial inflammatory bowel disease (IBD) is a homogenous subgroup, phenotypically different from sporadic disease. Our aim was to determine the clinical presentation in a large CD population. METHODOLOGY: 564 CD patients (m/f: 278/286, age: 37.4 (SD 12.7) yrs, duration: 8.4 (7.1) yrs) were included. Disease phenotype was determined according to Vienna classification. Familial disease, extraintestinal manifestations (EIM), need for surgery and smoking habits were also analyzed. RESULTS: Familial IBD was present in 73 (12.9%) patients. Age at onset and presence of EIMs was associated with familial disease. Penetrating (44.6% vs. <10 yrs: 29.1%, P<0.0001) and ileocolonic disease (54.4% vs. 42.8%, P=0.03) were more common in patients with a disease duration of > or =10 yrs. In a logistic regression model female gender, colonic/ileocolonic location, smoking and familial IBD were independent risk factors for EIMs, while ileal and non-inflammatory disease increased the risk for resections. Smoking was also associated with frequent relapses. CONCLUSIONS: Familial IBD was associated with the presence of EIMs, while ileal involvement and noninflammatory behavior independently increased the risk for surgery. Since penetrating and extensive disease was more frequent in patients with longer disease duration our data support a possible change in location and behavior during the course of disease.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
egyetemen (Magyarországon) készült közlemény
Megjelenés:Hepato-Gastroenterology. - 52 : 63 (2005), p. 817-822. -
További szerzők:Szalay Ferenc (belgyógyász) Tulassay Zsolt (1944-) (belgyógyász, gasztroenterológus) Molnár Tamás (orvos Szeged) Kovács Ágota Gasztonyi Beáta Papp János (Budapest) Lakatos László (Veszprém) Altorjay István (1954-) (belgyógyász, gasztroenterológus, onkológus) The Hungarian IBD Study Group
Internet cím:Intézményi repozitóriumban (DEA) tárolt változat
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4.

001-es BibID:BIBFORM028489
Első szerző:Lakatos Péter (Semmelweis Egyetem)
Cím:DLG5 R30Q is not associated with IBD in Hungarian IBD patients but predicts clinical response to steroids in Crohn's disease / Lakatos P. L., Fischer S., Claes K., Kovacs A., Molnar T., Altorjay I., Demeter P., Tulassay Z., Palatka K., Papp M., Rutgeerts P., Szalay F., Papp J., Vermeire S., Lakatos L., The Hungarian IBD Study Group
Dátum:2006
ISSN:1078-0998
Megjegyzések:Recent data suggest that haplotypic variants of the DLG5 gene on 10q23 are associated with susceptibility to inflammatory bowel disease (IBD) in Germany. In view of the geographical differences in frequency of genetic markers and the absence of data in Central European patients, our aim was to determine the DLG5 R30Q variant in Hungarian IBD patients. MATERIALS AND METHODS: We investigated 773 unrelated IBD patients (age 38.1 +/- 10.3 years; duration, 8.8 +/- 7.5 years; Crohn's disease [CD]: 639; male/female, 309/330; duration, 8.4 +/- 7.1 years; ulcerative colitis [UC]: 134; male/female, 63/71; duration, 10.6 +/- 8.9 years) and 150 healthy subjects. DLG5 R30Q and TLR4 D299G variants were tested by polymerase chain reaction/restriction fragment length polymorphism. DNA was screened for NOD2/CARD15 mutations by denaturing high-performance liquid chromatography. Detailed clinical phenotype was determined by reviewing the medical charts. RESULTS: The frequency of the R30Q variant allele was not significantly different in IBD (22.0%), CD (20.8%), and UC (27.6%) patients compared with healthy control subjects (28.0%). In CD, the 113A variant allele was associated with steroid resistance (16.3% vs noncarriers, 7.6%; odds ratio [OR], 2.4; 95% CI 1.3-4.5; P = 0.013). In a logistic regression model carriage of DLG5 R30Q, perianal involvement and frequent relapses were independently associated with steroid resistance. No phenotype-genotype associations were found in UC patients, although a trend toward more extensive disease was observed in carriers of the variant allele (OR = 2.1; 95% CI 0.95-4.4; P = 0.07). CONCLUSIONS: The present data strongly contrast previous data from Germany. DLG5 113A is not associated with disease susceptibility, but there was a tendency for this allele to confer resistance to steroids. Further studies are required to evaluate the significance of DLG5 in other populations from geographically diverse regions.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
egyetemen (Magyarországon) készült közlemény
Megjelenés:Inflammatory Bowel Diseases. - 12 : 5 (2006), p. 362-368. -
További szerzők:Fischer Simon Claes, Karolien Kovács Ágota Molnár Tamás (orvos Szeged) Altorjay István (1954-) (belgyógyász, gasztroenterológus, onkológus) Demeter Pál Tulassay Zsolt (1944-) (belgyógyász, gasztroenterológus) Palatka Károly (1961-) (belgyógyász, gasztroenterológus) Papp Mária (1975-) (belgyógyász, gasztroenterológus) Rutgeerts, Paul Szalay Ferenc (belgyógyász) Papp János (Budapest) Vermeire, S. Lakatos László (Veszprém) The Hungarian IBD Study Group
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5.

001-es BibID:BIBFORM013687
Első szerző:Papp Mária (belgyógyász, gasztroenterológus)
Cím:Presence of Anti-Microbial Antibodies in Liver Cirrhosis : a Tell-Tale Sign of Compromised Immunity? / Papp Maria, Norman Gary L., Vitalis Zsuzsanna, Tornai Istvan, Altorjay Istvan, Földi Ildikó, Udvardy Miklos, Shums Zakera, Dinya Tamas, Orosz Peter, Lombay Bela, Par Gabriella, Par Alajos, Veres Gabor, Csak Timea, Osztovits Janos, Szalay Ferenc, Lakatos Peter Laszlo
Dátum:2010
ISSN:0163-2116
Megjegyzések:Bacterial translocation plays important role in the complications of liver cirrhosis. Antibody formation against various microbial antigens is common in Crohn's disease and considered to be caused by sustained exposure to gut microflora constituents. We hypothesized that anti-microbial antibodies are present in patients with liver cirrhosis and may be associated with the development of bacterial infections. Methodology/Principal Findings: Sera of 676 patients with various chronic liver diseases (autoimmune diseases:266, viral hepatitis C:124, and liver cirrhosis of different etiology:286) and 100 controls were assayed for antibodies to Saccharomyces cerevisiae(ASCA) and to antigens derived from two intestinal bacterial isolates (one gram positive, one gram negative, neither is Escherichia coli). In patients with liver cirrhosis, we also prospectively recorded the development of severe episodes of bacterial infection. ASCA and anti-OMP PlusTM antibodies were present in 38.5% and 62.6% of patients with cirrhosis and in 16% and 20% of controls, respectively (p,0.001). Occurrence of these antibodies was more frequent in cases of advanced cirrhosis (according to Child-Pugh and MELD score; p,0.001) or in the presence of ascites (p,0.001). During the median follow-up of 425 days, 81 patients (28.3%) presented with severe bacterial infections. Anti-microbial antibody titers (p = 0.003), as well as multiple seroreactivity (p = 0.036), was associated with infectious events. In logistic regression analysis, the presence of ascites (OR:1.62, 95%CI:1.16?2.25), co-morbidities (OR:2.22, 95%CI:1.27?3.86), and ASCA positivity (OR:1.59, 95%CI:1.07?2.36) were independent risk factors for severe infections. A shorter time period until the first infection was associated with the presence of ASCA (p = 0.03) and multiple seropositivity (p = 0.037) by Kaplan-Meier analysis, and with Child-Pugh stage (p = 0.018, OR:1.85) and co-morbidities (p,0.001, OR:2.02) by Cox-regression analysis. Conclusions/Significance: The present study suggests that systemic reactivity to microbial components reflects compromised mucosal immunity in patients with liver cirrhosis, further supporting the possible role of bacterial translocation in the formation of anti-microbial antibodies.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Haptoglobin polymorphism
Crohn's disease
Disease behavior
Th1/Th2 orientation
Primary sclerosing cholangitis
egyetemen (Magyarországon) készült közlemény
Megjelenés:PloS One. - 5 : 9 (2010), p. e12957-1-e12957-9. -
További szerzők:Norman, Gary L. Vitális Zsuzsanna (1963-) (belgyógyász, gasztroenterológus) Tornai István (1954-) (belgyógyász, gasztroenterológus) Altorjay István (1954-) (belgyógyász, gasztroenterológus, onkológus) Földi Ildikó (1981-) (orvos) Udvardy Miklós (1947-) (belgyógyász, haematológus) Shums, Zakera Dinya Tamás (1974-) (sebész szakorvos, onkológus szakorvos) Orosz Péter (Miskolc) Lombay Béla Jr. Pár Gabriella Pár Alajos Veres Gábor (1969-2020) (csecsemő- és gyermekgyógyász, gasztroenterológus) Csak Timea Osztovits János Szalay Ferenc (belgyógyász) Lakatos Péter (Semmelweis Egyetem)
Internet cím:DOI
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