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001-es BibID:	BIBFORM039993
Első szerző:	Jókay István (fül-orr-gégész)
Cím:	The effecct of chronic otitis media on the immunoreactivity of human inner ear / Jokay, I., Papp, Z., Soos, G., Sziklai, I., Dezso, B.
Dátum:	2001
ISSN:	0937-4477
Megjegyzések:	Twenty temporal bones (TBs) were removed from autopsy cases and prepared for immunohistochemical examination. Ten TBs were free of ear disease whereas the other ten TBs showed the signs of chronic otitis media. Expression of markers for monocyte-macrophages (25F9, 27E10) and natural killer cells (anti-Leu-11) was examined immunohistochemically. There were no specific positive stainings with 25F9 or anti-Leu-11 antibodies in any of the specimens. Staining for 27E10 was found to be negative in each section obtained from normal cochlea. However, 27E10 positivity was detected in three of ten TBs with signs of chronic ear inflammation. This positivity can be explained by two theories: (1) activated monocytes can enter the inner ear from the systemic circulation as a consequence of chronic antigen challenge; (2) mesothelial cells could become activated as a result of a cross-reaction, with resultant positivity. Development of sensorineural hearing loss in some cases of chronic otitis media may be due to these immunological reactions. PMID: 11829190 [PubMed - indexed for MEDLINE]
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	European Archives Of Oto-Rhino-Laryngology. - 258 : 10 (2001), p. 529-532. -
További szerzők:	Papp Zoltán (1971-) (fül-orr-gégész) Soós Györgyike (1959-) (pathológus) Sziklai István (1954-) (fül-orr-gégész) Dezső Balázs (1951-) (pathológus)
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001-es BibID:	BIBFORM001624
Első szerző:	Karosi Tamás (fül-orr-gégész)
Cím:	Expression of measles virus receptors in otosclerotic, non-otosclerotic and in normal stapes footplates / Karosi Tamás, Jókay István, Kónya József, Petkó Mihály, Z. Szabó László, Sziklai István
Dátum:	2007
Megjegyzések:	Otosclerosis is a bone remodeling disorder of complex etiology. Persistent measles virus infection of the otic capsule could increase the expression level of measles virus receptors (CD46) on the osteoclasts and endothelial cells of the otosclerotic foci. Presence of measles virus RNA was demonstrated in the footplates of histologically diagnosed otosclerotic patients by RT-PCR; however, no reports were available about the CD46 expression pattern and level in otosclerosis. Nucleic acid was extracted from stapes footplates of clinically otosclerotic patients (N = 116). Genomic RNA of measles virus was amplified by RT-PCR. Amplification results were correlated with postoperative histologic and CD46 specific immunhistologic findings. Among 116 stapes fixation cases, 87 otosclerotic stapes contained measles virus RNA. Histology for virus negative stapes (N = 29) represented degenerative disorders with heterogeneous histopathology. Active otosclerosis was featured by increased numbers of osteoclasts showing strong CD46 expression. In virus negative, non-otosclerotic stapes fixation and in normal stapes footplates weak CD46 immunoreaction was demonstrated on the osteocytes and fibroblasts. In otosclerosis, it is reasonable to assume that measles virus increases the expression level of its own cellular receptor. Furthermore, intensive CD46 reaction could relate to active virus replication and continuous receptor internalisation. Otosclerosis is a disease of disturbed osteoid turnover due to persistent measles virus infection and special CD46 receptor pattern of the otic capsule.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban footplate measles virus
Megjelenés:	European Archives of Oto-Rhino-Laryngology 264 : 6 (2007), p. 607-613. -
További szerzők:	Jókay István (1954-) (fül-orr-gégész) Kónya József (1964-) (szakorvos, klinikai mikrobiológus) Petkó Mihály (1943-) (orvos, neurobiológus) Z. Szabó László Sziklai István (1954-) (fül-orr-gégész)
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