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001-es BibID:BIBFORM033526
035-os BibID:PMID:20155824 WOS:000279432400036
Első szerző:Akhmetshina, Alfiya
Cím:Decreased lymphatic vessel counts in patients with systemic sclerosis : association with fingertip ulcers / Alfiya Akhmetshina, Jürgen Beer, Karin Zwerina, Matthias Englbrecht, Katrin Palumbo, Clara Dees, Nicole Reich, Jochen Zwerina, Gabriella Szucs, Johannes Gusinde, Tatiana Nevskaya, Oliver Distler, Dontscho Kerjaschki, Georg Schett, Jörg H. W. Distler
Dátum:2010
ISSN:0004-3591
Megjegyzések:Systemic sclerosis (SSc) is a connective tissue disease that is characterized by microvascular disease and tissue fibrosis. Progressive loss and irregular architecture of the small blood vessels are well characterized, but the potential involvement of the lymphatic vessel system has not been analyzed directly in SSc. This study was undertaken to assess whether the lymphatic vascular system is affected in SSc, and whether changes to the lymphatic vessels are associated with dystrophic changes and tissue damage in patients with SSc. METHODS: Lymphatic endothelial cells in skin biopsy samples from patients with SSc and age- and sex-matched healthy volunteers were identified by staining for podoplanin and prox-1, both of which are specifically expressed in lymphatic endothelial cells but not in blood vascular endothelial cells. CD31 was used as a pan-endothelial cell marker. Statistical analyses were performed using Kruskal-Wallis, Mann-Whitney U, and Spearman's rank correlation tests. RESULTS: The numbers of podoplanin- and prox-1-positive lymphatic vessels were significantly reduced in patients with SSc as compared with healthy individuals. The number of podoplanin-positive lymphatic precollector vessels was significantly lower in SSc patients with fingertip ulcers than in SSc patients without ulcers. Moreover, the number of lymphatic vessels correlated inversely with the number of fingertip ulcers at the time of biopsy and with the number of fingertip ulcers per year. The inverse correlation between lymphatic precollector vessel counts and fingertip ulcers remained significant after statistical adjustment for the blood vessel count, age, and modified Rodnan skin thickness score. CONCLUSION: These results demonstrate a severe reduction in the number of lymphatic capillaries and lymphatic precollector vessels in patients with SSc. Patients with decreased lymphatic vessel counts may be at particularly high risk of developing fingertip ulcers.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
külföldön készült közlemény
Megjelenés:Arthritis and Rheumatism. - 62 : 5 (2010), p. 1513-1522. -
További szerzők:Beer, Jürgen Zwerina, Karin Englbrecht, Matthias Palumbo, Katrin Dees, Clara Reich, Nicole Zwerina, Jochen Szűcs Gabriella (1963-) (belgyógyász, allergológus és klinikai immunológus, reumatológus) Gusinde, Johannes Nevskaya, Tatiana Distler, Oliver Kerjaschki, Dontscho Schett, Georg Distler, Jörg H. W.
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001-es BibID:BIBFORM033505
035-os BibID:PMID:18668558 WOS:000259055400042
Első szerző:Akhmetshina, Alfiya
Cím:Rho-associated kinases are crucial for myofibroblast differentiation and production of extracellular matrix in scleroderma fibroblasts / Alfiya Akhmetshina, Clara Dees, Margarita Pileckyte, Gabriella Szucs, Bernd M. Spriewald, Jochen Zwerina, Oliver Distler, Georg Schett, Jörg H. W. Distler
Dátum:2008
ISSN:0004-3591
Megjegyzések:Rho-associated kinases (Rock) are the major cellular mediators of Rho GTPases and play an important role in the organization of the actin cytoskeleton. Inhibitors of Rock are currently being evaluated for the treatment of pulmonary arterial hypertension. This study was undertaken to analyze the role of Rock in the activation of fibroblasts in systemic sclerosis (SSc). METHODS: Rock signaling was inhibited using chemical inhibitors and small interfering RNA. The expression of extracellular matrix (ECM) proteins and alpha-smooth muscle actin was analyzed by real-time polymerase chain reaction, Western blotting, and SirCol assay. Metabolic activity was quantified by MTT assay. Cell viability was assessed by staining with annexin V and propidium iodide. The role of MAP kinases was investigated using selective inhibitors and Western blotting. RESULTS: Inhibition of Rock strongly reduced the synthesis of the major ECM proteins at the messenger RNA level as well as the protein level. Counterregulatory changes in the expression of tissue inhibitors of metalloproteinases and matrix metalloproteinases were not observed. Inhibition of Rock prevented myofibroblast differentiation. Transforming growth factor beta activated ERK in a Rock-dependent manner, and ERK mediated in part the stimulatory effects of Rock on myofibroblast differentiation. Toxic adverse effects of the inhibition of Rock were not observed. CONCLUSION: Our findings demonstrate that Rock potently stimulates the differentiation of resting fibroblasts into myofibroblasts and the production of ECM at biologically relevant concentrations without cell toxicity. These findings, along with the beneficial effects of Rock inhibition on vascular disease, indicate that inhibition of Rock might be an interesting novel therapeutic approach for the treatment of SSc.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
külföldön készült közlemény
Megjelenés:Arthritis And Rheumatism. - 58 : 8 (2008), p. 2553-2564. -
További szerzők:Dees, Clara Pileckyte, Margarita Szűcs Gabriella (1963-) (belgyógyász, allergológus és klinikai immunológus, reumatológus) Spriewald, Bernd M. Zwerina, Jochen Distler, Oliver Schett, Georg Distler, Jörg H. W.
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3.

001-es BibID:BIBFORM072682
Első szerző:Hudson, Marie
Cím:Exposure to ACE inhibitors prior to the onset of scleroderma renal crisis : results from the International Scleroderma Renal Crisis Survey / Hudson Marie, Baron Murray, Tatibouet Solène, Furst Daniel E., Khanna Dinesh, International Scleroderma Renal Crisis Study Investigators
Dátum:2014
ISSN:0049-0172
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
scleroderma renal crisis
Megjelenés:Seminars In Arthritis And Rheumatism. - 43 : 5 (2014), p. 666-672. -
További szerzők:Baron, Murray Tatibouet, Solène Furst, Daniel E. Khanna, Dinesh Szűcs Gabriella (1963-) (belgyógyász, allergológus és klinikai immunológus, reumatológus) International Scleroderma Renal Crisis Study Investigators
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001-es BibID:BIBFORM033048
Első szerző:Kerekes György (belgyógyász, kardiológus, angiológus)
Cím:Adalimumab improves endothelial function and microcirculation in rheumatoid arthritisas determined by simultaneous assessment of brachial artery flow-mediated vasodilation and laser doppler flowmetry / György Kerekes, Vanda Pongrácz, Szilvia Szamosi, Gabriella Szücs, Andrea Váncsa, Orsolya Tímár, Zoltán Csiki, Edit Végh, Pál Soltész, Zoltan Szekanecz
Dátum:2011
ISSN:0004-3591
Tárgyszavak:Orvostudományok Klinikai orvostudományok idézhető absztrakt
Megjelenés:Arthritis and rheumatism. - 63 : 10 (2011), p. S74. -
További szerzők:Pongrácz Vanda Szamosi Szilvia (1975-) (belgyógyász, reumatológus) Szűcs Gabriella (1963-) (belgyógyász, allergológus és klinikai immunológus, reumatológus) Váncsa Andrea (1972-) (orvos) Tímár Orsolya (1980-) (belgyógyász) Csiki Zoltán (1962-) (belgyógyász, allergológus, klinikai immunológus, reumatológus) Végh Edit (1978-) (reumatológus, belgyógyász) Soltész Pál (1961-) (belgyógyász, kardiológus) Szekanecz Zoltán (1964-) (reumatológus, belgyógyász, immunológus)
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