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001-es BibID:	BIBFORM007056
Első szerző:	Czirják László
Cím:	Survival and causes of death in 366 Hungarian patients with systemic sclerosis / Czirjak, L., Kumanovics, G., Varju, C., Nagy, Z., Pakozdi, A., Szekanecz, Z., Szucs, G.
Dátum:	2008
ISSN:	1468-2060 (Electronic)
Megjegyzések:	Survival analysis of a series of 366 consecutive patients with systemic sclerosis (SSc). METHODS: Clinical and laboratory data were evaluated from 1983 until 2005 using a standard protocol. The female/male ratio was 315/51. The mean (SD) age of the patients was 56.8 (12.2) years. The duration of disease was 12 (5-19) years with a median follow-up of 6 (3-12) years. RESULTS: Kaplan-Meier univariate analysis showed that renal, cardiac involvement, pigmentation disturbances, malabsorption, a forced vital capacity <50%, diffuse scleroderma, presence of early malignancy, anaemia, and increased erythrocyte sedimentation rate (ESR) were signs of unfavourable prognosis, whereas anti-centromere antibodies were indicators of a good survival. In the multivariate Cox proportional hazards model the presence of diffuse scleroderma, renal involvement, coexistence of a malignant disease, and increased ESR were poor independent prognostic signs. Elderly age at the onset of disease also caused an unfavourable outcome. A total of 86 SSc-related deaths were recorded during the follow-up. Of them, 65% were attributed to cardiorespiratory manifestation of disease. Tumour associated early death was found in 12 cases (14%). CONCLUSIONS: In addition to the well-known factors influencing the outcome (diffuse subset, internal organ involvements, and inflammatory signs), the coexistence of scleroderma with a malignancy also causes a poor outcome.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban Adult Age Factors Aged Autoantibodies/blood Blood Sedimentation Cause of Death Centromere Female Heart Diseases Humans Kidney Diseases Male Middle Aged Neoplasms Prognosis Proportional Hazards Models Prospective Studies Scleroderma, Systemic Survival Analysis
Megjelenés:	Annals of the Rheumatic Diseases. - 67 : 1 (2008), p. 59-63. -
További szerzők:	Kumánovics Gábor Varjú Cecília Nagy Zoltán (orvos) Pákozdi Angéla Szekanecz Zoltán (1964-) (reumatológus, belgyógyász, immunológus) Szűcs Gabriella (1963-) (belgyógyász, allergológus és klinikai immunológus, reumatológus)
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