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001-es BibID:BIBFORM033526
035-os BibID:PMID:20155824 WOS:000279432400036
Első szerző:Akhmetshina, Alfiya
Cím:Decreased lymphatic vessel counts in patients with systemic sclerosis : association with fingertip ulcers / Alfiya Akhmetshina, Jürgen Beer, Karin Zwerina, Matthias Englbrecht, Katrin Palumbo, Clara Dees, Nicole Reich, Jochen Zwerina, Gabriella Szucs, Johannes Gusinde, Tatiana Nevskaya, Oliver Distler, Dontscho Kerjaschki, Georg Schett, Jörg H. W. Distler
Dátum:2010
ISSN:0004-3591
Megjegyzések:Systemic sclerosis (SSc) is a connective tissue disease that is characterized by microvascular disease and tissue fibrosis. Progressive loss and irregular architecture of the small blood vessels are well characterized, but the potential involvement of the lymphatic vessel system has not been analyzed directly in SSc. This study was undertaken to assess whether the lymphatic vascular system is affected in SSc, and whether changes to the lymphatic vessels are associated with dystrophic changes and tissue damage in patients with SSc. METHODS: Lymphatic endothelial cells in skin biopsy samples from patients with SSc and age- and sex-matched healthy volunteers were identified by staining for podoplanin and prox-1, both of which are specifically expressed in lymphatic endothelial cells but not in blood vascular endothelial cells. CD31 was used as a pan-endothelial cell marker. Statistical analyses were performed using Kruskal-Wallis, Mann-Whitney U, and Spearman's rank correlation tests. RESULTS: The numbers of podoplanin- and prox-1-positive lymphatic vessels were significantly reduced in patients with SSc as compared with healthy individuals. The number of podoplanin-positive lymphatic precollector vessels was significantly lower in SSc patients with fingertip ulcers than in SSc patients without ulcers. Moreover, the number of lymphatic vessels correlated inversely with the number of fingertip ulcers at the time of biopsy and with the number of fingertip ulcers per year. The inverse correlation between lymphatic precollector vessel counts and fingertip ulcers remained significant after statistical adjustment for the blood vessel count, age, and modified Rodnan skin thickness score. CONCLUSION: These results demonstrate a severe reduction in the number of lymphatic capillaries and lymphatic precollector vessels in patients with SSc. Patients with decreased lymphatic vessel counts may be at particularly high risk of developing fingertip ulcers.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
külföldön készült közlemény
Megjelenés:Arthritis and Rheumatism. - 62 : 5 (2010), p. 1513-1522. -
További szerzők:Beer, Jürgen Zwerina, Karin Englbrecht, Matthias Palumbo, Katrin Dees, Clara Reich, Nicole Zwerina, Jochen Szűcs Gabriella (1963-) (belgyógyász, allergológus és klinikai immunológus, reumatológus) Gusinde, Johannes Nevskaya, Tatiana Distler, Oliver Kerjaschki, Dontscho Schett, Georg Distler, Jörg H. W.
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2.

001-es BibID:BIBFORM033505
035-os BibID:PMID:18668558 WOS:000259055400042
Első szerző:Akhmetshina, Alfiya
Cím:Rho-associated kinases are crucial for myofibroblast differentiation and production of extracellular matrix in scleroderma fibroblasts / Alfiya Akhmetshina, Clara Dees, Margarita Pileckyte, Gabriella Szucs, Bernd M. Spriewald, Jochen Zwerina, Oliver Distler, Georg Schett, Jörg H. W. Distler
Dátum:2008
ISSN:0004-3591
Megjegyzések:Rho-associated kinases (Rock) are the major cellular mediators of Rho GTPases and play an important role in the organization of the actin cytoskeleton. Inhibitors of Rock are currently being evaluated for the treatment of pulmonary arterial hypertension. This study was undertaken to analyze the role of Rock in the activation of fibroblasts in systemic sclerosis (SSc). METHODS: Rock signaling was inhibited using chemical inhibitors and small interfering RNA. The expression of extracellular matrix (ECM) proteins and alpha-smooth muscle actin was analyzed by real-time polymerase chain reaction, Western blotting, and SirCol assay. Metabolic activity was quantified by MTT assay. Cell viability was assessed by staining with annexin V and propidium iodide. The role of MAP kinases was investigated using selective inhibitors and Western blotting. RESULTS: Inhibition of Rock strongly reduced the synthesis of the major ECM proteins at the messenger RNA level as well as the protein level. Counterregulatory changes in the expression of tissue inhibitors of metalloproteinases and matrix metalloproteinases were not observed. Inhibition of Rock prevented myofibroblast differentiation. Transforming growth factor beta activated ERK in a Rock-dependent manner, and ERK mediated in part the stimulatory effects of Rock on myofibroblast differentiation. Toxic adverse effects of the inhibition of Rock were not observed. CONCLUSION: Our findings demonstrate that Rock potently stimulates the differentiation of resting fibroblasts into myofibroblasts and the production of ECM at biologically relevant concentrations without cell toxicity. These findings, along with the beneficial effects of Rock inhibition on vascular disease, indicate that inhibition of Rock might be an interesting novel therapeutic approach for the treatment of SSc.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
külföldön készült közlemény
Megjelenés:Arthritis And Rheumatism. - 58 : 8 (2008), p. 2553-2564. -
További szerzők:Dees, Clara Pileckyte, Margarita Szűcs Gabriella (1963-) (belgyógyász, allergológus és klinikai immunológus, reumatológus) Spriewald, Bernd M. Zwerina, Jochen Distler, Oliver Schett, Georg Distler, Jörg H. W.
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3.

001-es BibID:BIBFORM095918
035-os BibID:(WoS)000680314700003 (Scopus)85111813495 (PubMed)34341562
Első szerző:Szekanecz Zoltán (reumatológus, belgyógyász, immunológus)
Cím:Autoinflammation and autoimmunity across rheumatic and musculoskeletal diseases / Zoltan Szekanecz, Iain B. McInnes, Georg Schett, Szilvia Szamosi, Szilvia Benkő, Gabriella Szűcs
Dátum:2021
ISSN:1759-4790 1759-4804
Megjegyzések:Most rheumatic and musculoskeletal diseases (RMDs) can be placed along a spectrum of disorders, with autoinflammatory diseases (including monogenic systemic autoinflammatory diseases) and autoimmune diseases (such as systemic lupus erythematosus and antiphospholipid syndrome) representing the two ends of this spectrum. However, although most autoinflammatory diseases are characterized by the activation of innate immunity and inflammasomes and classical autoimmunity typically involves adaptive immune responses, there is some overlap in the features of autoimmunity and autoinflammation in RMDs. Indeed, some 'mixed-pattern' diseases such as spondyloarthritis and some forms of rheumatoid arthritis can also be delineated. A better understanding of the pathogenic pathways of autoinflammation and autoimmunity in RMDs, as well as the preferential cytokine patterns observed in these diseases, could help us to design targeted treatment strategies
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:Nature Reviews Rheumatology. - 17 : 10 (2021), p. 585-595. -
További szerzők:McInnes, Iain B. Schett, Georg Szamosi Szilvia (1975-) (belgyógyász, reumatológus) Benkő Szilvia (1973-) (molekuláris biológus) Szűcs Gabriella (1963-) (belgyógyász, allergológus és klinikai immunológus, reumatológus)
Pályázati támogatás:TAMOP-4.2.4.A/2-11/1-2012-0001
TÁMOP
GINOP-2.3.2-15-2016-00015
GINOP
GINOP-2.3.2-15-2016-00050
GINOP
NKFIH-OTKA K131844
OTKA
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4.

001-es BibID:BIBFORM067625
Első szerző:Szentpétery Ágnes (reumatológus)
Cím:Effects of targeted therapies on the bone in arthritides / Ágnes Szentpétery, Ágnes Horváth, Katalin Gulyás, Zsófia Pethö, Harjit Pal Bhattoa, Sándor Szántó, Gabriella Szücs, Oliver FitzGerald, Georg Schett, Zoltán Szekanecz
Dátum:2017
ISSN:1568-9972
Megjegyzések:Inflammatory arthritides, such as rheumatoid arthritis (RA) and spondyloarthritides (SpA) have been associated with both localized bone resorption and/or formation, and generalized osteoporosis. Systemic inflammation may be the major driver for bone loss in arthritis. In RA and peripheral SpA the RANK-RANKL-OPG network is involved in bone resorption, while in axial SpA the Wnt-?-catenin axis and its inhibitors (DKK-1, sclerostin) are the most relevant. Targeted therapies including biologics and small molecule tyrosine kinase inhibitors may interfere with inflammatory bone metabolism. Most of these compounds are able to slow down radiographic progression and osteoporosis in arthritides. In very early cases of non-radiological SpA, there may be a window of opportunity allowing to prevent syndesmophyte formation. The inability of targeted therapies to increase the production of DKK-1 and sclerostin may explain the lack of efficacy of TNF inhibitors to halt syndesmophyte formation in SpA. Further clinical trials are needed to better understand the bone effects of targeted therapies.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Biologics
Bone loss
DKK-1
Erosion
JAK inhibitors
Osteoporosis
Osteoprotegerin
RANKL
Rheumatoid arthritis
Sclerostin
Spondyloarthritis
Syndesmophyte
Megjelenés:Autoimmunity Reviews 16 : 3 (2017), p. 313-320. -
További szerzők:Horváth Ágnes (1985-) (reumatológus) Gulyás Katalin (reumatológus) Pethő Zsófia (1981-) (reumatológus, immunológus) Bhattoa Harjit Pal (1973-) (laboratóriumi szakorvos) Szántó Sándor (1968-) (belgyógyász, reumatológus) Szűcs Gabriella (1963-) (belgyógyász, allergológus és klinikai immunológus, reumatológus) FitzGerald, Oliver Schett, Georg Szekanecz Zoltán (1964-) (reumatológus, belgyógyász, immunológus)
Pályázati támogatás:K 105073
OTKA
TÁMOP-4.2.4.A/2-11-1-2012-0001
TÁMOP
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5.

001-es BibID:BIBFORM072621
035-os BibID:(WoS)000394513300006 (Scopus)84991729113
Első szerző:van Steenbergen, Hanna W.
Cím:EULAR definition of arthralgia suspicious for progression to rheumatoid arthritis / van Steenbergen Hanna W., Aletaha Daniel, Beaart-van de Voorde Liesbeth J. J., Brouwer Elisabeth, Codreanu Catalin, Combe Bernard, Fonseca João E., Hetland Merete L., Humby Frances, Kvien Tore K., Niedermann Karin, Nuňo Laura, Oliver Sue, Rantapää-Dahlqvist Solbritt, Raza Karim, van Schaardenburg Dirkjan, Schett Georg, De Smet Liesbeth, Szücs Gabriella, Vencovský Jirí, Wiland Piotr, de Wit Maarten, Landewé Robert L., van der Helm-van Mil Annette H. M.
Dátum:2017
ISSN:0003-4967
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Annals Of The Rheumatic Diseases. - 76 : 3 (2017), p. 491-496. -
További szerzők:Aletaha, Daniel Beaart-van de Voorde, Liesbeth J. J. Brouwer, Elisabeth Codreanu, Catalin Combe, Bernard Fonseca, João Hetland, Merete L. Humby, Frances Kvien, Tore K. Niedermann, Karin Nuňo, Laura Oliver, Sue Rantapää-Dahlqvist, Solbritt Raza, Karim van Schaardenburg, Dirkjan Schett, Georg De Smet, Liesbeth Szűcs Gabriella (1963-) (belgyógyász, allergológus és klinikai immunológus, reumatológus) Vencovsky, Jiri Wiland, Piotr de Wit, Maarten Landewé, Robert van der Helm-van Mil, Annette
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