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001-es BibID:	BIBFORM033529
035-os BibID:	PMID:19147617
Első szerző:	Kowal-Bielecka, Otylia
Cím:	EULAR recommendations for the treatment of systemic sclerosis : a report from the EULAR Scleroderma Trials and Research group (EUSTAR) / O. Kowal-Bielecka, R. Landewé, J. Avouac, S. Chwiesko, I. Miniati, L. Czirjak, P. Clements, C. Denton, D. Farge, K. Fligelstone, I. Földvari, D. E. Furst, U. Müller-Ladner, J. Seibold, R. M. Silver, K. Takehara, B. Garay Toth, A. Tyndall, G. Valentini, F. van den Hoogen, F. Wigley, F. Zulian, Marco Matucci-Cerinic, EUSTAR co-authors
Dátum:	2009
ISSN:	0003-4967
Megjegyzések:	PURPOSE: The optimal treatment of systemic sclerosis (SSc) is a challenge because the pathogenesis of SSc is unclear and it is an uncommon and clinically heterogeneous disease affecting multiple organ systems. The aim of the European League Against Rheumatism (EULAR) Scleroderma Trials and Research group (EUSTAR) was to develop evidence-based, consensus-derived recommendations for the treatment of SSc. METHODS: To obtain and maintain a high level of intrinsic quality and comparability of this approach, EULAR standard operating procedures were followed. The task force comprised 18 SSc experts from Europe, the USA and Japan, two SSc patients and three fellows for literature research. The preliminary set of research questions concerning SSc treatment was provided by 74 EUSTAR centres. RESULTS: Based on discussion of the clinical research evidence from published literature, and combining this with current expert opinion and clinical experience, 14 recommendations for the treatment of SSc were formulated. The final set includes the following recommendations: three on SSc-related digital vasculopathy (Raynaud's phenomenon and ulcers); four on SSc-related pulmonary arterial hypertension; three on SSc-related gastrointestinal involvement; two on scleroderma renal crisis; one on SSc-related interstitial lung disease and one on skin involvement. Experts also formulated several questions for a future research agenda. CONCLUSIONS: Evidence-based, consensus-derived recommendations are useful for rheumatologists to help guide treatment for patients with SSc. These recommendations may also help to define directions for future clinical research in SSc.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban egyetemen (Magyarországon) készült közlemény
Megjelenés:	Annals Of The Rheumatic Diseases. - 68 : 5 (2009), p. 620-628. -
További szerzők:	Landewé, Robert Avouac, Jérôme Chwiesko, S. Miniati, I. Czirják László Clements, Philip Denton, Christopher Farge, D. Fligelstone, Kim Földvári I. Furst, Daniel E. Müller-Ladner, Ulf Seibold, J. Silver, R. M. Takehara, Kazuhiro Garay Tóth B. Tyndall, Alan Valentini, Gabriele Hoogen, F. van den Wigley, Frederic Zulian, Francesco Matucci-Cerinic, Marco Szűcs Gabriella (1963-) (belgyógyász, allergológus és klinikai immunológus, reumatológus) Szekanecz Zoltán (1964-) (reumatológus, belgyógyász, immunológus) EUSTAR
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001-es BibID:	BIBFORM057704
035-os BibID:	(WoS)000373403800019 (Scopus)84930163748
Első szerző:	Mihai, Carina
Cím:	Digital ulcers predict a worse disease course in patients with systemic sclerosis / Carina Mihai, Robert Landewé, Désirée van der Heijde, Ulrich A. Walker, Paul I. Constantin, Ana Maria Gherghe, Ruxandra Ionescu, Simona Rednic, Yannick Allanore, Jérôme Avouac, László Czirják, Eric Hachulla, Gabriela Riemekasten, Franco Cozzi, Paolo Airò, Maurizio Cutolo, Ulf Mueller-Ladner, Marco Matucci-Cerinic, EUSTAR co-authors
Dátum:	2016
ISSN:	0003-4967
Megjegyzések:	OBJECTIVE: Systemic sclerosis (SSc) is a systemic autoimmune disease with high morbidity and significant mortality. There is a great need of predictors that would allow risk stratification of patients with SSc and ultimately initiation of treatment early enough to ensure optimal clinical results. In this study, we evaluated whether a history of digital ulcers (HDU) at presentation may be a predictor of vascular outcomes and of overall clinical worsening and death in patients with SSc. METHODS: Patients from the EULAR Scleroderma Trials and Research (EUSTAR) database, satisfying at inclusion the 1980 American College of Rheumatology classification criteria for SSc, who had a follow-up of at least 3 years since baseline or who have died, were included in the analysis. HDU at presentation as a predictor of disease worsening or death was evaluated by Cox proportional hazards regression analysis. RESULTS: 3196 patients matched the inclusion criteria (male sex 13.2%, 33.4% diffuse subset). At presentation, 1092/3196 patients had an HDU (34.1%). In multivariable analysis adjusting for age, gender and all parameters considered potentially significant, HDU was predictive for the presence of active digital ulcers (DUs) at prospective visits (HR (95% CI)): 2.41 (1.91 to 3.03), p<0.001, for an elevated systolic pulmonary arterial pressure on heart ultrasound (US-PAPs):1.36 (1.03 to 1.80), p=0.032, for any cardiovascular event (new DUs, elevated US-PAPs or LV failure): 3.56 (2.26 to 5.62), p<0.001, and for death (1.53 (1.16 to 2.02), p=0.003). CONCLUSIONS: In patients with SSc, HDU at presentation predicts the occurrence of DUs at follow-up and is associated with cardiovascular worsening and decreased survival. Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk systemic sclerosis
Megjelenés:	Annals of The Rheumatic Diseases. - 75 : 4 (2016), p. 681-686. -
További szerzők:	Landewé, Robert Heijde, Désirée van der Walker, Ulrich Constantin, Paul I. Gherghe, Ana Maria Ionescu, Ruxandra Rednic, Simona Allanore, Yannick Avouac, Jérôme Czirják László Hachulla, Eric Riemekasten, Gabriela Cozzi, Franco Airò, Paolo Cutolo, Maurizio Mueller-Ladner, Ulf Matucci-Cerinic, Marco Szűcs Gabriella (1963-) (belgyógyász, allergológus és klinikai immunológus, reumatológus) EUSTAR
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001-es BibID:	BIBFORM072621
035-os BibID:	(WoS)000394513300006 (Scopus)84991729113
Első szerző:	van Steenbergen, Hanna W.
Cím:	EULAR definition of arthralgia suspicious for progression to rheumatoid arthritis / van Steenbergen Hanna W., Aletaha Daniel, Beaart-van de Voorde Liesbeth J. J., Brouwer Elisabeth, Codreanu Catalin, Combe Bernard, Fonseca João E., Hetland Merete L., Humby Frances, Kvien Tore K., Niedermann Karin, Nuňo Laura, Oliver Sue, Rantapää-Dahlqvist Solbritt, Raza Karim, van Schaardenburg Dirkjan, Schett Georg, De Smet Liesbeth, Szücs Gabriella, Vencovský Jirí, Wiland Piotr, de Wit Maarten, Landewé Robert L., van der Helm-van Mil Annette H. M.
Dátum:	2017
ISSN:	0003-4967
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	Annals Of The Rheumatic Diseases. - 76 : 3 (2017), p. 491-496. -
További szerzők:	Aletaha, Daniel Beaart-van de Voorde, Liesbeth J. J. Brouwer, Elisabeth Codreanu, Catalin Combe, Bernard Fonseca, João Hetland, Merete L. Humby, Frances Kvien, Tore K. Niedermann, Karin Nuňo, Laura Oliver, Sue Rantapää-Dahlqvist, Solbritt Raza, Karim van Schaardenburg, Dirkjan Schett, Georg De Smet, Liesbeth Szűcs Gabriella (1963-) (belgyógyász, allergológus és klinikai immunológus, reumatológus) Vencovsky, Jiri Wiland, Piotr de Wit, Maarten Landewé, Robert van der Helm-van Mil, Annette
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