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001-es BibID:	BIBFORM039993
Első szerző:	Jókay István (fül-orr-gégész)
Cím:	The effecct of chronic otitis media on the immunoreactivity of human inner ear / Jokay, I., Papp, Z., Soos, G., Sziklai, I., Dezso, B.
Dátum:	2001
ISSN:	0937-4477
Megjegyzések:	Twenty temporal bones (TBs) were removed from autopsy cases and prepared for immunohistochemical examination. Ten TBs were free of ear disease whereas the other ten TBs showed the signs of chronic otitis media. Expression of markers for monocyte-macrophages (25F9, 27E10) and natural killer cells (anti-Leu-11) was examined immunohistochemically. There were no specific positive stainings with 25F9 or anti-Leu-11 antibodies in any of the specimens. Staining for 27E10 was found to be negative in each section obtained from normal cochlea. However, 27E10 positivity was detected in three of ten TBs with signs of chronic ear inflammation. This positivity can be explained by two theories: (1) activated monocytes can enter the inner ear from the systemic circulation as a consequence of chronic antigen challenge; (2) mesothelial cells could become activated as a result of a cross-reaction, with resultant positivity. Development of sensorineural hearing loss in some cases of chronic otitis media may be due to these immunological reactions. PMID: 11829190 [PubMed - indexed for MEDLINE]
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	European Archives Of Oto-Rhino-Laryngology. - 258 : 10 (2001), p. 529-532. -
További szerzők:	Papp Zoltán (1971-) (fül-orr-gégész) Soós Györgyike (1959-) (pathológus) Sziklai István (1954-) (fül-orr-gégész) Dezső Balázs (1951-) (pathológus)
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