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001-es BibID:	BIBFORM036824
Első szerző:	Emri Eszter (Ph.D hallgató)
Cím:	Correlation among metallothionein expression, intratumoural macrophage infiltration and the risk of metastasis in human cutaneous malignant melanoma / E. Emri, K. Egervari, T. Varvölgyi, D. Rozsa, E. Miko, B. Dezső, I. Veres, G. Mehes, G. Emri, E. Remenyik
Dátum:	2013
ISSN:	0926-9959
Megjegyzések:	Background: The formation of metastases and the efficacy of systemic therapies in cutaneous malignant melanoma (CMM) depend on the characteristics of the tumour cells and the host immune response. Aberrant expression of metallothionein (MT) has been observed in several types of cancers with poor prognoses. Objective: To perform an immunohistochemical study on primary CMM comparing the MT expression of tumours without metastases (n = 23) to that of samples with haematogenous metastases (n = 23) and to examine the correlation between MT staining and immunological markers relevant in CMM progression. Methods: The immunohistochemical labelling of different tumour sections was analysed using tissue microarrays for the evaluation of the suitability of this method in future studies. Results: Our results suggest that MT overexpression is significantly more frequent in primary CMM with haematogenous metastases (P = 0.018) and that the overexpression is independent of the Breslow tumour thickness (R = 0.102, P = 0.501). Interestingly, MT overexpression of the tumour cells was correlated with the presence of tumour-infiltrating CD68(+) macrophages (P = 0.003), a known predictive factor for melanoma progression, thereby suggesting a role for MT in the development of a defective host immune response. Furthermore, the presence of CD163(+) macrophages infiltrating the tumours correlated with metastasis formation (P < 0.001), whereas the presence CD1a(+) dendritic cells surrounding the tumours was associated with a lower risk of haematogenous spread (P = 0.003). Conclusion: Our results demonstrate that MT may represent a suitable prognostic factor that can characterize the metastasising ability of CMM and the tumour-promoting host immune response.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban Egészség- és Környezettudomány
Megjelenés:	Journal of The European Academy of Dermatology and Venereology. - 27 : 3 (2013), p. e320-e327. -
További szerzők:	Egervári Kristóf (1983-) (patológus) Várvölgyi Tünde (1984-) (bőrgyógyász) Rózsa Dávid (1982-) (Ph.D hallgató) Mikó Edit (1980-) (biológus) Dezső Balázs (1951-) (pathológus) Veres Imre (1963-) (bőrgyógyász) Méhes Gábor (1966-) (patológus) Emri Gabriella (1972-) (bőrgyógyász, allergológus, onkológus) Remenyik Éva (1956-) (bőrgyógyász)
Pályázati támogatás:	TÁMOP-4.2.1/B-09/1/KONV-2010-0007 TÁMOP Az UV fény DNS károsító hatásának in vitro vizsgálata K68401 OTKA TÁMOP-4.2.2.-08/1-2008-0019 TÁMOP
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat DOI
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001-es BibID:	BIBFORM051259
Első szerző:	Töröcsik Dániel (bőrgyógyász)
Cím:	Detection of factor XIII-A is a valuable tool for distinguishing dendritic cells and tissue macrophages in granuloma annulare and necrobiosis lipoidica / D. Töröcsik, H. Bárdos, Zs. Hatalyák, B. Dezső, G. Losonczy, L. Paragh, Z. Péter, M. Balázs, E. Remenyik, R. Ádány
Dátum:	2014
ISSN:	0926-9959
Megjegyzések:	BACKGROUND: Factor XIII subunit A (FXIII-A) is used as a diagnostic marker in a wide range of dermatological diseases ranging from inflammatory lesions to malignancies, although neither the cell types responsible for its expression nor the mechanism(s) resulting in its local accumulation in pathological conditions have been characterized. OBJECTIVE: In this study, we aimed to gain information on the cells showing an immunohistochemical reaction for FXIII-A and answer the question whether macrophages and/or dendritic cells are labelled for FXIII-A. METHODS: We carried out our studies on samples of granuloma annulare (GA) and necrobiosis lipoidica (NL), the prime examples for granulomatous skin lesions with a non-infectious background in which extracellular matrix remodelling is a key feature without any sign of malignant transformation. We used markers for macrophages and dendritic cells in combination with the detection of FXIII-A in double labelling immunohistochemical reactions. RESULTS: We demonstrated that FXIII-A positivity clearly distinguishes macrophages (CD163+/FXIII-A+) from dendritic cells (CD11c+/FXIII-A-) not only in the normal dermis as previously described by Zaba et al. (J Clin Invest 2007; 117: 2517-2525) but also in the pathological conditions of GA and NL. Detecting the expression of DC-SIGN/CD209 and mannose receptor molecules on FXIII-A+ macrophages we confirmed that FXIII-A is expressed in the alternatively activated macrophages. However, while DC-SIGN/CD209 was invariably expressed on FXIII-A+ cells both in normal and pathological conditions of GA/NL (98.7% vs. 93.5/96%), mannose receptor was only partially coexpressed with FXIII-A (94.8% vs. 74.7/52.2%), suggesting that FXIII-A+ macrophages do not represent a homogenous population. CONCLUSIONS: FXIII-A selectively marks macrophages and distinguishes them from dendritic cells. The presence of FXIII-A is not a disease-specific marker but indicates a possible common mechanism of macrophage activation in various dermatological diseases.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	Journal of the European Academy of Dermatology and Venereology. - 28 : 8 (2014), p. 1087-1096. -
További szerzők:	Bárdos Helga (1969-) (megelőző orvostan és népegészségtan szakorvos) Hatalyák Zs. Dezső Balázs (1951-) (pathológus) Losonczy Gergely (1977-) (szemész) Paragh Lilla (1986-) (bőrgyógyász) Péter Zoltán (1964-) (bőrgyógyász) Balázs Margit (1952-) (sejtbiológus, molekuláris genetikus) Remenyik Éva (1956-) (bőrgyógyász) Ádány Róza (1952-) (megelőző orvostan és népegészségtan szakorvos)
Pályázati támogatás:	K81847 OTKA PD101557 OTKA TÁMOP-4.2.2.A-11/1/KONV-2012-0031 TÁMOP
Internet cím:	DOI Intézményi repozitóriumban (DEA) tárolt változat
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