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1.

001-es BibID:BIBFORM038800
035-os BibID:PMID:16092549
Első szerző:Borkó Rezső
Cím:Electromotile performance of isolated outer hair cells during slow motile shortening / Rezső Borkó, Tamás József Batta, István Sziklai
Dátum:2005
ISSN:0001-6489
Megjegyzések:The electromotile performance of isolated OHCs does not seem to be dependent on slow motile shortening alone; other mechanisms, such as phosphorylation, are also involved. OBJECTIVE: To elucidate the relationship between the magnitude of electromotile displacements and magnitude of slow motile shortening of outer hair cells (OHCs) induced by mechanical or chemical stimulation over a reversible range. MATERIAL AND METHODS: Isolated guinea pig OHCs were mechanically (0.6 microl/min perfusion of saline; n =4) or chemically and mechanically (0.6 microl/min perfusion of 12.5 mM KCl; n =4) stimulated in a glass microchamber to evoke slow motile shortening. RESULTS: Combined mechanical and chemical stimulation evoked greater OHC shortening than mechanical stimulation alone. Both forms of stimulation resulted in reversible shortening. Electromotility was measured using low voltage (+/- 35 mV) and higher voltage (up to +/- 240 mV) electrical pulses mimicking the receptor potential at different stages of cell shortening. The magnitude of electromotility decreased simultaneously with slow motile shortenings of OHCs. Irrespective of the character of the stimulus (mechanical or mechanical + chemical), the decrease in the magnitude of electromotility was dependent on the degree of cell shortening. Ocadaic acid, a protein phosphatase inhibitor, blocked slow motility and decreased the magnitude of electromotility.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
egyetemen (Magyarországon) készült közlemény
Megjelenés:Acta Oto-Laryngologica. - 125 : 5 (2005), p. 547-551. -
További szerzők:Batta József Tamás (1970-) (fül-orr-gégész) Sziklai István (1954-) (fül-orr-gégész)
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2.

001-es BibID:BIBFORM033110
035-os BibID:PMID:22385409
Első szerző:Csomor Péter (biotechnológus)
Cím:Expression of bone morphogenetic protein 2, 4, 5, and 7 correlates with histological activity of otosclerotic foci / Péter Csomor, Balázs Liktor, Bálint Liktor, Zoltán Szekanecz, István Sziklai, Tamás Karosi
Dátum:2012
ISSN:0001-6489
Megjegyzések:Abstract Conclusion: This study is the first to establish that bone morphogenetic protein 5 (BMP5) plays a role in the pathogenesis of otosclerosis. These results confirm that elevated expression levels of BMPs, members of the transforming growth factor (TGF)-? superfamily, contribute to the pathologically increased bone turnover in early, active stages of otosclerosis. Objectives: Otosclerosis is a complex bone remodeling disorder of the otic capsule, which might be characterized by increased expression of different types of BMPs. TGF-? and BMP are both members of the TGF-? superfamily and play a critical role in bone resorption and new bone formation. It has been suggested that BMP and its receptors may be involved in the pathologically increased bone turnover observed in otosclerosis. Methods: Fifty-one otosclerotic and 16 non-otosclerotic ankylotic stapes footplates were histologically analyzed: conventional hematoxylin-eosin staining and BMP2, 4, 5, and 7specific immunofluorescent assays were performed. Cortical bone fragments (n = 35) and incus specimens (n = 6) were used as negative controls. Results: Active otosclerosis (n = 39) was characterized by increased expression of BMP2, 4, 5, and 7. Inactive cases of otosclerosis (n = 12) were characterized by negative immunoreaction for BMPs. Non-otosclerotic stapes specimens (n = 16) and negative controls (n = 41) showed negligible BMP expression. The BMP expression pattern showed a strong correlation with the histological activity of otosclerosis.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Bone remodelling disorder
non-otosclerotic stapes fixation
stapes
egyetemen (Magyarországon) készült közlemény
Megjelenés:Acta Oto-Laryngologica. - 132 : 6 (2012), p. 624-631. -
További szerzők:Liktor Balázs (1984-) Liktor Bálint Szekanecz Zoltán (1964-) (reumatológus, belgyógyász, immunológus) Sziklai István (1954-) (fül-orr-gégész) Karosi Tamás (1979-) (fül-orr-gégész)
Pályázati támogatás:PD75371
OTKA
K81480
OTKA
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DOI
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3.

001-es BibID:bibEBI13784
Első szerző:Farkas Zsolt (fül-orr-gégész)
Cím:Potassium-induced slow motility is partially calcium-dependent in isolated outer hair cells / Farkas, Zs., Sziklai, I.
Dátum:2003
Megjegyzések:Low flow rate (0.6 microl/min) administration of high concentration potassium solutions (12.5, 25 and 37.5 mM) was tested for evoking slow-motility length changes in isolated, apical turn, guinea pig outer hair cells (OHCs) (length 65-80 microm; n = 38). Control OHCs (n = 16) showed a flow rate-dependent, reversible, longitudinal shortening of 0.5-3 microm during perfusion with normal saline. Potassium, an effective depolarizing agent for OHCs, induced a concentration-dependent cell shortening of 0.5-13 microm. These cell shape changes were reversible. The magnitude of shortening was significantly (p < 0.01) decreased in a calcium-free incubation medium (n = 8). The velocity of the shortening was 300 nm/s in the first 10 s after application of 37.5 mM K+ in a normal incubation medium and decreased to 100 nm/s during the next 10 s. Corresponding velocities in calcium-free solutions were 100 and 50 nm/s, respectively. K+-induced shortening velocities were not significantly different from control values after 30 s. It appears that K+-induced OHC shortening is sensitive to the calcium content of the incubation medium during the first 10 s. Higher flow rate (1.5 microl/min) administration of K+ makes the velocity and magnitude of slow motility of OHCs insensitive to the absence of calcium. These results highlight the fact that one of the critical technical points in fluid perfusion experiments with isolated OHCs is selecting a safe low flow rate of < 0.6 microl/min. At this perfusion rate, K+-induced OHC shortening is composed of both calcium-sensitive and -insensitive components.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Acta Oto-Laryngologica. - 123 : 2 (2003), p. 160-163. -
További szerzők:Sziklai István (1954-) (fül-orr-gégész)
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4.

001-es BibID:BIBFORM040484
Első szerző:Gróf J.
Cím:Non-collagen proteins of stapedial bone matrix in perilymph of otosclerotic patients / Gróf J., Sziklai I., Ribári O., Menyhárt J.
Dátum:1985
ISSN:0001-6489
Megjegyzések:Fül- Orr- Gége Klinika, Szent- Györgyi Albert Orvostudományi Egyetem, Szeged
Non-collagen proteins extracted from the otosclerotic stapes footplate, superstructure and temporal cortical bone were compared with the protein patterns of normal and otosclerotic perilymph by analytical isotachophoresis (ITP). Normal and otosclerotic perilymph yielded basically identical isotachophoretic subfractions. Thirteen subfractions were detected moving as anions at pH 9.6 in the normal perilymph, versus 16 subfractions of similar character in the otosclerotic perilymph. Of these 16 protein subfractions, one (which was not detected in the normal perilymph) could be found in the ITP-gram of the stapes footplate non-collagen proteins, but not of the stapes superstructure or temporal cortical bone. Our results support the concept that protein can enter the inner ear fluid spaces from the otosclerotic bone. The biological significance of these proteins has not yet been clarified.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Acta Oto-Laryngologica. - 99 : 5-6 (1985), p. 557-563. -
További szerzők:Sziklai István (1954-) (fül-orr-gégész) Ribári Ottó (1932-) (fül-orr-gégész, audiológus) Menyhárt J.
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5.

001-es BibID:BIBFORM040482
Első szerző:Ribári Ottó (fül-orr-gégész, audiológus)
Cím:Examination of noncollagen protein composition of the footplate and superstructure of the otosclerotic stapes / Ribári O., Sziklai I.
Dátum:1983
ISSN:0001-6489
Megjegyzések:Fül- Orr- Gége Klinika, Szent- Györgyi Albert Orvostudományi Egyetem, Szeged
We have differentially precipitated 2 fractions of noncollagen proteins extracted from separately pooled superstructure and footplate of surgically removed stapes of patients from both sexes, who have suffered from otosclerosis. The two fractions were: EDTA-soluble, CaCl2 precipitable (Fraction-1) and EDTA-soluble, CaCl2 non-precipitable proteins. The protein pattern of these two fractions was compared by isoelectric focusing and two-dimensional gel electrophoresis. The phosphoprotein fraction (Fraction-1) of the otosclerotic stapes footplate contained acidic (pI 3-6), low molecular weight (20-40 kD) proteins, which were not detected in the superstructure and temporal cortical bone. Two-dimensional mapping of the Fraction-2 showed predominantly acidic proteins in the footplate and some basic minor components in the superstructure. The lack of the low molecular weight proteins in the superstructure proves the localisation of the otosclerotic process only in the footplate.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Acta Oto-Laryngologica. - 95 : 5-6 (1983), p. 580-584. -
További szerzők:Sziklai István (1954-) (fül-orr-gégész)
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6.

001-es BibID:BIBFORM040486
Első szerző:Ribári Ottó (fül-orr-gégész, audiológus)
Cím:Oversulfated mucopolysaccharides in the otosclerotic bone / Ribári O., Pereplica M., Sziklai I.
Dátum:1991
ISSN:0001-6489
Megjegyzések:Mucopolysaccharides (glucosaminoglycans, GAGs) were extracted from otosclerotic and non-otosclerotic human stapes footplate, stapes superstructure and guinea pig stapes footplate. Cellulose acetate electrophoresis revealed an unknown highly anionic band (Rf = 1.05) beside the conventional hyaluronic acid, chondroitin sulfate and heparan sulfate fractions. Chemical analysis resulted in a high sulfate/hexosamine molar ratio in the otosclerotic GAG extract (1.7 and 1.9) and a very low ratio in non-otosclerotic human stapes and normal guinea pig stapes footplate GAG extract (0.20 and 0.21, respectively). Hexuronic acid content was highest in guinea pig stapes GAG preparation. Our results serve as indirect evidence of the presence of an oversulfated GAG fraction in the otosclerotic bone, which can potentially initiate otosclerotic bone resorption.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Acta Oto-Laryngologica. - 111 : 2 (1991), p. 362-365. -
További szerzők:Pereplica, M. Sziklai István (1954-) (fül-orr-gégész)
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7.

001-es BibID:BIBFORM040487
Első szerző:Ribári Ottó (fül-orr-gégész, audiológus)
Cím:Cathepsin D activity in otosclerotic bone and perilymph / Ribári O., Sziklai I.
Dátum:1988
ISSN:0001-6489
Megjegyzések:Otosclerotic bone and perilymph samples obtained during stapedectomy operations from patients suffering from pure conductive hearing loss of at least 40 dBs air-bone gap at 500 Hz. Control perilymph samples derived from patients suffering from round window membrane rupture or Meniere's disease. Enzyme activities were determined using a synthetic fluorogenic substrate by fluorescence spectrophotometry. No significant differences have been found between the protein content of otosclerotic and normal or non-otosclerotic perilymph samples. Cathepsin D activity was significantly higher (p less than 0.001) in the otosclerotic perilymph samples. Otosclerotic stapes footplate contained more activity than normal meatal cortical bone as well, though the difference was not significant. Biological significance of the elevated Cathepsin D activity must be considered.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Acta Oto-Laryngologica. - 105 : 5-6 (1988), p. 549-552. -
További szerzők:Sziklai István (1954-) (fül-orr-gégész)
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8.

001-es BibID:BIBFORM040489
Első szerző:Ribári Ottó (fül-orr-gégész, audiológus)
Cím:Cochlear implantation improves hearing in the contralateral ear / Ribári O., Sziklai I.
Dátum:1995
ISSN:0001-6489
Megjegyzések:The electrical stimulation of deaf ears by cochlear implants (CI) improved contralateral hearing in seven patients: 5 intracochlear (IC) (analogue processor) and 2 extracochlear (EC) (digital processor) implants. Our patients obtained best speech discrimination scores (98% + 2%, n = 11) when lip reading and CI were combined with a high-power hearing aid fitted into the contralateral ear. Contralateral hearing improvement was 10-15 dB sound pressure level (SPL) at frequencies up to 4000 Hz; hearing in a previously totally deaf ear recovered 4-6 months after CI. The phenomenon was independent of the type of speech-encoding (analogue or digital). Five out of 6 reimplanted patients who first received an 8-channel digital-pulsatile EC reported better speech discrimination after the second CI, when IC devices were implanted with analogue speech processors. These results suggest that EC implantation should be considered in childhood as a first choice, since i) It does not exclude the possibility of a second IC implantation with the same success rate as for the first; ii) The inner ear sensory epithelium remains intact after EC implantation, and consequently, if any regenerating process takes place in the implanted ear due to electrical stimulation it may provide more physiological hearing later on.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Acta Oto-Laryngologica. - 115 : 2 (1995), p. 260-263. -
További szerzők:Sziklai István (1954-) (fül-orr-gégész)
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9.

001-es BibID:BIBFORM040600
Első szerző:Sterkers, Olivier
Cím:Possible role of Ca ions in the vestibular system / O. Sterkers, C. Bernard, E. Ferrery, I. Sziklai, P. Tran Ba Huy, C. Amiel
Dátum:1988
ISSN:0001-6489
Megjegyzések:The Ca++ messenger system is nearly universally present in the control of cell functions by extracellular messengers. It elicits different kinds of responses: either brief, as in neurotransmission and in skeletal muscle contraction, or sustained, as in smooth muscle contraction and in the regulation of transepithelial transport systems. In this latter function the Ca++ messenger system interacts with other cellular modulation systems such as cAMP production and arachidonic acid cascade. In the vestibular apparatus, the Ca++ messenger system is involved in the transduction processes in that it controls both the release of neurotransmitter at the basal pole of the hair cell and the electrical resonance of the cell. It also figures in the contractile properties of cochlear outer hair cells. The Ca++ messenger system as well as adenylate cyclase and prostaglandins may play an important role in the modulation of endolymph secretion.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Acta oto-laryngologica. Supplementum. - 460 (1988), p. 28-32. -
További szerzők:Bernard, C. Ferrery, E. Sziklai István (1954-) (fül-orr-gégész) Tran Ba Huy, P. Amiel, Claude
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10.

001-es BibID:BIBFORM040483
Első szerző:Sziklai István (fül-orr-gégész)
Cím:Possible role of peptides derived from otosclerotic bone in the mechanism of sensorineural hearing loss / Sziklai I., Gróf J., Ribári O., Menyhárt J.
Dátum:1985
ISSN:0001-6489
Megjegyzések:Fül- Orr- Gége Klinika, Szent- Györgyi Albert Orvostudományi Egyetem, Szeged
Otosclerotic stapes footplates, superstructures and temporal cortical bones were extracted with 0.25 M guanidine X HCl 0.5 M EDTA (pH 7.4) solution. The extracted non-collagenous peptides/proteins were separated chromatographically on a Sephadex G-25 microcolumn. The peptide composition of the bone samples were compared by capillary analytical isotachophoresis (ITP) in the molecular mass range 0.3-5 kD. The otosclerotic stapes footplate contained 13 ITP subfractions, while the stapes superstructures and cortical bone contained only 9 and 10, respectively. An otosclerosis-specific ITP subfraction was also detected in the stapes footplate, but not in the stapes superstructure or cortical bone. This subfraction was previously demonstrated in the otosclerotic perilymph as well. Four ITP subfractions occurred common in the otosclerotic stapes footplate, the superstructure and the cortical bone. Two of these common subfractions were not found in the cortical bone peptide extract, but all of them revealed higher than normal levels in the otosclerotic perilymph.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Acta Oto-Laryngologica. - 100 : 3-4 (1985), p. 253-259. -
További szerzők:Gróf J. Ribári Ottó (1932-) (fül-orr-gégész, audiológus) Menyhárt J.
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11.

001-es BibID:BIBFORM040485
Első szerző:Sziklai István (fül-orr-gégész)
Cím:Peptides of the otosclerotic perilymph examined by analytical isotachophoresis / Sziklai I., Gróf J., Ribári O., Menyhárt J., Piffko P.
Dátum:1985
ISSN:0001-6489
Megjegyzések:Fül- Orr- Gége Klinika, Szent- Györgyi Albert Orvostudományi Egyetem, Szeged
Perilymphs of normal and otosclerotic origin were separated chromatographically on a Sephadex G-25 microcolumn. Peptide composition of the perilymphs was compared by capillary analytical isotachophoresis in the molecular mass range 0.3-5 kD. Otosclerotic perilymph samples contain a heterogeneous, UV-absorbing peptide subfraction which is not detected in the normal perilymph. Normal and otosclerotic perilymph, furthermore, contain four common subfractions detected in twice the normal concentration in the otosclerotic perilymph. These ITP subfractions are degraded during acid hydrolysis (6 M HCI). On the contrary, otosclerosis is a deficient state compared with the normal, as the number of peptides or oligoglycopeptides is twice as high in normal as in otosclerotic perilymph, beside the otosclerosis specific peptides.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Acta Oto-Laryngologica. - 99 : 1-2 (1985), p. 25-34. -
További szerzők:Gróf J. Ribári Ottó (1932-) (fül-orr-gégész, audiológus) Menyhárt J. Piffko, P.
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12.

001-es BibID:BIBFORM040488
Első szerző:Sziklai István (fül-orr-gégész)
Cím:Electrochemical composition of the cochlear fluids in the early experimental hydrops : preliminary results / Sziklai I., Horner K. C., Ferrary E., Sterkers O., Amiel C.
Dátum:1989
ISSN:0001-6489
Megjegyzések:The composition of endolymph and perilymph was studied in the guinea pig cochlea after 2 and 6 weeks of blockage of the vestibular aqueduct in an experimental model of hydrops. Compound action potential was monitored several times in the observation period. The endocochlear potential was measured and the endolymph was sampled at the first and third turns of the scala media. The Na, K, and Cl concentrations were determined in nanolitre aliquots of endolymph and of perilymph, the latter sampled from the basal scala vestibuli. After 2 weeks, no change in endolymphatic electrochemical composition was observed. After 6 weeks, endocochlear potential was decreased by 25% at both cochlear turns; K concentration was decreased in endolymph of the basal turn and Cl concentration was decreased in both turns; the calculated osmolality (Na + K + Cl) was decreased in both turns. These results indicate that the blockage of the vestibular aqueduct induced early auditory dysfunction whereas alterations of the electrochemical composition of endolymph occurred later after a time lag of more than 2 and less than 6 weeks.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Acta Oto-Laryngologica. - 107 : 5-6 (1989), p. 371-374. -
További szerzők:Horner, K. C. Ferrary, Evelyne Sterkers, Olivier Amiel, Claude
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