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001-es BibID:	BIBFORM103016
035-os BibID:	(cikkazonosító)e0264328 (Scopus)85125687513 (Wos)000776002200027
Első szerző:	Kokas Zsófia
Cím:	Do Hungarian multiple sclerosis care units fulfil international criteria? / Kokas Zsófia, Sandi Dániel, Fricska-Nagy Zsanett, Füvesi Judit, Biernacki Tamás, Köves Ágnes, Fazekas Ferenc, Birkás Adrienne Jóri, Katona Gabriella, Kovács Krisztina, Milanovich Dániel, Dobos Enikő, Kapás István, Jakab Gábor, Csépány Tünde, Bense Erzsébet, Mátyás Klotild, Rum Gábor, Szolnoki Zoltán, Deme István, Jobbágy Zita, Kriston Dávid, Gerócs Zsuzsanna, Diószeghy Péter, Bors László, Varga Adrián, Kerényi Levente, Molnár Gabriella, Kristóf Piroska, Nagy Zsuzsanna Ágnes, Sátori Mária, Imre Piroska, Péntek Szilvia, Klivényi Péter, Kincses Zsigmond Tamás, Vécsei László, Bencsik Krisztina
Dátum:	2022
ISSN:	1932-6203
Megjegyzések:	A patients Because of the past 3 decades' extensive research, several disease modifying therapies became available, thus a paradigm change is multiple sclerosis care was necessary. In 2018 a therapeutic guideline was created recommending that treatment of persons with multiple sclerosis should take place in specified care units where the entire spectrum of disease modifying therapies is available, patient monitoring is ensured, and therapy side effects are detected and treated promptly. In 2019 multiple sclerosis care unit criteria were developed, emphasizing personnel and instrumental requirements to provide most professional care. However, no survey was conducted assessing the real-world adaptation of these criteria. Objective To assess whether Hungarian care units fulfil international criteria. Methods A self-report questionnaire was assembled based on international guidelines and sent to Hungarian care units focusing on 3 main aspects: personnel and instrumental background, disease-modifying therapy use, number of people living with multiple sclerosis receiving care in care units. Data on number of persons with multiple sclerosis were compared to Hungarian prevalence estimates. Descriptive statistics were used to analyse data. Results Out of 27 respondent care units, 3 fulfilled minimum requirements and 7 fulfilled minimum and recommended requirements. The least prevalent neighbouring specialties were spasticity and pain specialist, and neuro-ophthalmologist and oto-neurologist. Only 15 centres used all available disease modifying therapies. A total number of 7213 people with multiple sclerosis received care in 27 respondent centres. Compared to prevalence estimates, 2500 persons with multiple sclerosis did not receive multiple sclerosis specific care in Hungary. Conclusion Less than half of Hungarian care units provided sufficient care for people living with multiple sclerosis. Care units employing fewer neighbouring specialties, might have difficulties diagnosing and providing appropriate care for persons with multiple sclerosis, especially for people with progressive disease course, contributing to the reported low number of persons living with multiple sclerosis.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk
Megjelenés:	Plos One. - 17 : 3 (2022), p. 1-15. -
További szerzők:	Sandi Dániel Fricska-Nagy Zsanett Füvesi Judit Biernacki Tamás Köves Ágnes Fazakas Ferenc (1969-) (molekuláris biológus) Birkás Adrienne Jóri Katona Gabriella Kovács Krisztina Milanovich Dániel Dobos Enikő Kapás István (1965-) (neurológus, pszichiáter) Jakab Gábor Csépány Tünde (1956-) (neurológus, pszichiáter) Bense Erzsébet Mátyás Klotild Rum Gábor Szolnoki Zoltán Deme István Jobbágy Zita Kriston Dávid Gerócs Zsuzsanna Diószeghy Péter (1948-) (ideg- és elmeszakorvos) Bors László (Neurológus, Pécs) Varga Adrián Kerényi Levente Molnár Gabriella Kristóf Piroska Nagy Zsuzsanna Ágnes Sátori Mária Imre Piroska Péntek Szilvia Klivényi Péter Kincses Zsigmond Tamás Vécsei László (1954-) (neurológus) Bencsik Krisztina
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001-es BibID:	BIBFORM077070
035-os BibID:	(cikkazonosító)e0139659
Első szerző:	Nielsen, Helle H.
Cím:	The Urine Proteome Profile Is Different in Neuromyelitis Optica Compared to Multiple Sclerosis : a Clinical Proteome Study / Helle H. Nielsen, Hans C. Beck, Lars P. Kristensen, Mark Burton, Tunde Csepany, Magdolna Simo, Peter Dioszeghy, Tobias Sejbaek, Manuela Grebing, Niels H. H. Heegaard, Zsolt Illes
Dátum:	2015
ISSN:	1932-6203 1932-6203
Megjegyzések:	OBJECTIVES: Inflammatory demyelinating diseases of the CNS comprise a broad spectrum of diseases like neuromyelitis optica (NMO), NMO spectrum disorders (NMO-SD) and multiple sclerosis (MS). Despite clear classification criteria, differentiation can be difficult. We hypothesized that the urine proteome may differentiate NMO from MS. METHODS: The proteins in urine samples from anti-aquaporin 4 (AQP4) seropositive NMO/NMO-SD patients (n = 32), patients with MS (n = 46) and healthy subjects (HS, n = 31) were examined by quantitative liquid chromatography-tandem mass spectrometry (LC-MS/MS) after trypsin digestion and iTRAQ labelling. Immunoglobulins (Ig) in the urine were validated by nephelometry in an independent cohort (n = 9-10 pr. groups). RESULTS: The analysis identified a total of 1112 different proteins of which 333 were shared by all 109 subjects. Cluster analysis revealed differences in the urine proteome of NMO/NMO-SD compared to HS and MS. Principal component analysis also suggested that the NMO/NMO-SD proteome profile was useful for classification. Multivariate regression analysis revealed a 3-protein profile for the NMO/NMO-SD versus HS discrimination, a 6-protein profile for NMO/NMO-SD versus MS discrimination and an 11-protein profile for MS versus HS discrimination. All protein panels yielded highly significant ROC curves (AUC in all cases >0.85, p?0.0002). Nephelometry confirmed the presence of increased Ig-light chains in the urine of patients with NMO/NMO-SD. CONCLUSION: The urine proteome profile of patients with NMO/NMO-SD is different from MS and HS. This may reflect differences in the pathogenesis of NMO/NMO-SD versus MS and suggests that urine may be a potential source of biomarkers differentiating NMO/NMO-SD from MS.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	Plos One. - 10 : 10 (2015), p. 1-15. -
További szerzők:	Beck, Hans C. Kristensen, Lars P. Burton, Mark Csépány Tünde (1956-) (neurológus, pszichiáter) Simó Magdolna Diószeghy Péter (1948-) (ideg- és elmeszakorvos) Sejbaek, Tobias Grebing, Manuela Heegaard, Niels H. H. Illés Zsolt (neurológus, Pécs)
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