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001-es BibID:	BIBFORM101524
035-os BibID:	(cikkazonosító)949 (WoS)000801949300001 (Scopus)85129502844
Első szerző:	Borbély Katalin
Cím:	PET/MRI in the Presurgical Evaluation of Patients with Epilepsy: A Concordance Analysis / Borbély Katalin, Emri Miklós, Kenessey István, Tóth Márton, Singer Júlia, Barsi Péter, Vajda Zsolt, Pál Endre, Tóth Zoltán, Beyer Thomas, Dóczi Tamás, Bajzik Gábor, Fabó Dániel, Janszky József, Jordán Zsófia, Fajtai Dániel, Kelemen Anna, Juhos Vera, Wintermark Max, Nagy Ferenc, Moizs Mariann, Nagy Dávid, Lückl János, Repa Imre
Dátum:	2022
ISSN:	2227-9059
Megjegyzések:	The aim of our prospective study was to evaluate the clinical impact of hybrid [18F]-fluorodeoxyglucose positron emission tomography/magnetic resonance imaging ([18F]-FDG PET/MRI) on the decision workflow of epileptic patients with discordant electroclinical and MRI data. A novel mathematical model was introduced for a clinical concordance calculation supporting the classification of our patients by subgroups of clinical decisions. Fifty-nine epileptic patients with discordant clinical and diagnostic results or MRI negativity were included in this study. The diagnostic value of the PET/MRI was compared to other modalities of presurgical evaluation (e.g., electroclinical data, PET, and MRI). The results of the population-level statistical analysis of the introduced data fusion technique and concordance analysis demonstrated that this model could be the basis for the development of a more accurate clinical decision support parameter in the future. Therefore, making the establishment of "invasive" (operable and implantable) and "not eligible for any further invasive procedures" groups could be much more exact. Our results confirmed the relevance of PET/MRI with the diagnostic algorithm of presurgical evaluation. The introduction of a concordance analysis could be of high importance in clinical and surgical decision-making in the management of epileptic patients. Our study corroborated previous findings regarding the advantages of hybrid PET/MRI technology over MRI and electroclinical data.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk PET/MRI epilepsy
Megjelenés:	Biomedicines. - 10 : 5 (2022), p. 1-14. -
További szerzők:	Emri Miklós (1962-) (fizikus) Kenessey István Tóth Márton (1960-) (neurológus) Singer Júlia Barsi Péter Vajda Zsolt Pál Endre Tóth Zoltán Beyer, Thomas Dóczi Tamás Bajzik Gábor (1968-) (orvos) Fabó Dániel Janszky József Jordán Zsófia Fajtai Dániel Kelemen Anna Juhos Vera Wintermark, Max Nagy Ferenc (neurológus Kaposvár) Moizs Marianna (1964-) (orvos) Nagy Dávid Lückl János Repa Imre (1950-) (radiológus)
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM015757
Első szerző:	Györke Tamás
Cím:	Sapital standardisation of RCBF-SPECT in early dementia patients and healthy control subjects / T. Györke, P. Barsi, T. Kovács, I. Gyuricza, B. Kári, K. Karlinger, G. Balázs, G. Opposits, L. Trón, M. Emri
Dátum:	2007
Megjegyzések:	Aim: In order to perform population level statistical analysis (SPM) of rcbf-SPECT in early dementia we investigated the reliability of spatial standardisation (SS). Material and methods: SPECT and T1 weighted MRI investigations of 15 patients with early dementia and 11 healthy subjects were used. SS based on MRI and based only on SPECT data were compared using the statistical comparisons of the perfusion distributions measured in the same location of the brain. These areas were delineated in healthy regions with digital brain atlas software. For registration free of charge or commercially available and own developed softwares were applied. Results: We have shown that the MR based SS is more accurate than the SPECT based one. However the SPECT based SS offers good input for the population level SPM analysis. In the case of severely hypo-perfused areas the MRI images are indispensable. Conclusion: With the above limitations SPECT based SS proved to be reliable enough in this study population for the population level SPM analysis.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idézhető absztrakt
Megjelenés:	Nuclear Medicine Review. - 10 : 1 (2007), p. 50. -
További szerzők:	Barsi Péter Kovács Tamás Gyuricza István Kári Béla Karlinger Kinga Balázs Gergely Opposits Gábor (1974-) (fizikus, szoftver fejlesztő) Trón Lajos (1941-) (biofizikus) Emri Miklós (1962-) (fizikus)
Internet cím:	Szerző által megadott URL Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM015781
Első szerző:	Opposits Gábor (fizikus, szoftver fejlesztő)
Cím:	Experience with DICOM base multimodality medical image processing at the PET Center of the University of Debrecen / G. Opposits, M. Emri, P. Barsi, P. Bogner, O. Ésik, J. Julow, M. Kiss, J. Kollár, J. Martos, L. Trón
Dátum:	2005
Megjegyzések:	Background: Digital radiology ensures the possibility to process images recorded by different modalities in the same way and transmit them via the internet. This intention is facilitated by DICOM standard whose implementations may be very different. Material and methods: To overcome the problems arising from this variegation, we decided to supplement the software library developed at our department with a DICOM implementation. This allows for the identical data procession of files from national and international partners alike. Results: We routinely use CT and MRI data files in daily diagnostics as well as in the spatial standardization of brain activation examinations. Images and contours are transmitted in DICOM format to support the planning of irradiation. After the spring of 2005, all of the Debrecen patients will be given their PET images in DICOM for- mat. Conclusion: We have been given an opportunity to start methodological develo- pment in the field of cardiological image processing through the wider implementa- tion of DICOM standard.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idézhető absztrakt egyetemen (Magyarországon) készült közlemény
Megjelenés:	Nuclear Medicine Review. - 8 : 1 (2005), p. 75. -
További szerzők:	Emri Miklós (1962-) (fizikus) Barsi Péter Bogner Péter (1963-) (radiológus) Ésik Olga Julow Jenő Kiss Mihály (igazságügyi orvosszakértő) Kollár József (1950-) (radiológus) Martos János (igazságügyi orvosszakértő) Trón Lajos (1941-) (biofizikus)
Internet cím:	Szerző által megadott URL Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM096996
Első szerző:	Tóth Márton (neurológus)
Cím:	The role of hybrid FDG-PET/MRI on decision-making in presurgical evaluation of drug-resistant epilepsy / Tóth Márton, Barsi Péter, Tóth Zoltán, Borbély Katalin, Lückl János, Emri Miklós, Repa Imre, Janszky József, Dóczi Tamás, Horváth Zsolt, Halász Péter, Juhos Vera, Gyimesi Csilla, Bóné Beáta, Kuperczkó Diána, Horváth Réka, Nagy Ferenc, Kelemen Anna, Jordán Zsófia, Újvári Ákos, Hagiwara Koichi, Isnard Jean, Pál Endre, Fekésházy Attila, Fabó Dániel, Vajda Zsolt
Dátum:	2021
ISSN:	1471-2377
Megjegyzések:	Background: When MRI fails to detect a potentially epileptogenic lesion, the chance of a favorable outcome after epilepsy surgery becomes significantly lower (from 60 to 90% to 20?65%). Hybrid FDG-PET/MRI may provide additional information for identifying the epileptogenic zone. We aimed to investigate the possible effect of the introduction of hybrid FDG-PET/MRI into the algorithm of the decision-making in both lesional and non-lesional drug-resistant epileptic patients. Methods: In a prospective study of patients suffering from drug-resistant focal epilepsy, 30 nonlesional and 30 lesional cases with discordant presurgical results were evaluated using hybrid FDG-PET/MRI. Results: The hybrid imaging revealed morphological lesion in 18 patients and glucose hypometabolism in 29 patients within the nonlesional group. In the MRI positive group, 4 patients were found to be nonlesional, and in 9 patients at least one more epileptogenic lesion was discovered, while in another 17 cases the original lesion was confirmed by means of hybrid FDG-PET/MRI. As to the therapeutic decision-making, these results helped to indicate resective surgery instead of intracranial EEG (iEEG) monitoring in 2 cases, to avoid any further invasive diagnostic procedures in 7 patients, and to refer 21 patients for iEEG in the nonlesional group. Hybrid FDG-PET/MRI has also significantly changed the original therapeutic plans in the lesional group. Prior to the hybrid imaging, a resective surgery was considered in 3 patients, and iEEG was planned in 27 patients. However, 3 patients became eligible for resective surgery, 6 patients proved to be inoperable instead of iEEG, and 18 cases remained candidates for iEEG due to the hybrid FDG-PET/MRI. Two patients remained candidates for resective surgery and one patient became not eligible for any further invasive intervention. Conclusions: The results of hybrid FDG-PET/MRI significantly altered the original plans in 19 of 60 cases. The introduction of hybrid FDG-PET/MRI into the presurgical evaluation process had a potential modifying effect on clinical decision-making.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk Drug-resistant epilepsy PET/MRI Hybrid FDG-PET/MRI Clinical decision-making, Preoperative workflow Epilepsy surgery
Megjelenés:	BMC Neurology. - 21 : 1 (2021), p. 1-20. -
További szerzők:	Barsi Péter Tóth Zoltán Borbély Katalin Lückl János Emri Miklós (1962-) (fizikus) Repa Imre (1950-) (radiológus) Janszky József Dóczi Tamás Horváth Zsolt Halász Péter Juhos Vera Gyimesi Csilla Bóné Beáta Kuperczkó Diána Horváth Réka Nagy Ferenc (neurológus Kaposvár) Kelemen Anna Jordán Zsófia Újvári Ákos Hagiwara, Koichi Isnard, Jean Pál Endre Fekésházy Attila Fabó Dániel Vajda Zsolt
Pályázati támogatás:	GINOP-2.3.3-15- 2016-00032 GINOP EFOP-3.6.2-16-2017-00008 EFOP 2017- 1.2.1-NKP-2017-00002 Egyéb
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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