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001-es BibID:	BIBFORM062854
035-os BibID:	(WoS)000373317700004 (Scopus)84969785061
Első szerző:	Clemens Béla (neurológus)
Cím:	Egyedi loreta-abnormalitások vizsgálata idiopathiás generalizált epilepsziákban / Clemens Béla, Puskás Szilvia, Bessenyei Mónika, Kondákor István, Hollódy Katalin, Fogarasi András, Bense Katalin, Emri Miklós, Opposits Gábor, Kovács Noémi Zsuzsanna, Fekete István
Dátum:	2016
ISSN:	0019-1442
Tárgyszavak:	Orvostudományok Klinikai orvostudományok magyar nyelvű folyóiratközlemény hazai lapban folyóiratcikk
Megjelenés:	Ideggyógyászati Szemle. - 69 : 3-4 (2016), p. 107-121. -
További szerzők:	Puskás Szilvia (1979-) (neurológus) Bessenyei Mónika (1970-) (neurológus, csecsemő- és gyermekgyógyász) Kondákor István (1950-) (neurológus) Hollódy Katalin (1955-) (csecsemő- és gyermekgyógyász) Fogarasi András Bense Katalin Emri Miklós (1962-) (fizikus) Opposits Gábor (1974-) (fizikus, szoftver fejlesztő) Kovács Noémi Fekete István (1951-) (neurológus, pszichiáter)
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001-es BibID:	BIBFORM056215
Első szerző:	Clemens Béla (neurológus)
Cím:	Valproate treatment normalizes EEG functional connectivity in successfully treated idiopathic generalized epilepsy patients / B. Clemens, S. Puskás, M. Besenyei, N. Zs. Kovács, T. Spisák, S. A. Kis, M. Emri, K. Hollody, A. Fogarasi, I. Kondákor, I. Fekete
Dátum:	2014
Megjegyzések:	To investigate the effect of chronic VPA treatment of EEG functional connectivity in successfully treated idiopathic generalized epilepsy (IGE) patients. PATIENTS AND METHODS: 19-channel waking, resting-state EEG records of 26 IGE patients were analyzed before treatment (IGE) and after the 90th day of treatment (VPA), in seizure-free condition. Three minutes of artifact-free EEG background activity (without epileptiform potentials) was analyzed for each patient in both conditions. A group of 26 age-matched healthy normative control persons (NC) was analyzed in the same way. All the EEG samples were processed to LORETA (Low Resolution Electromagnetic Tomography) to localize multiple distributed sources of EEG activity. Current source density time series were generated for 33 regions of interest (ROI) in each hemisphere for four frequency bands. Pearson correlation coefficients (R) were computed between all ROIs in each hemisphere, for four bands across the investigated samples. R values corresponded to intrahemispheric, cortico-cortical functional EEG connectivity (EEGfC). Group and condition differences were analyzed by statistical parametric network method. MAIN RESULTS: p<0.05, corrected for multiple comparisons: (1) The untreated IGE group showed increased EEGfC in the delta and theta bands, and decreased EEGfC in the alpha band (as compared to the NC group); (2) VPA treatment normalized EEGfC in the delta, theta and alpha bands; and (3) degree of normalization depended on frequency band and cortical region. CONCLUSIONS: VPA treatment normalizes EEGfC in IGE patients.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk
Megjelenés:	Epilepsy Research. - 108 : 10 (2014), p. 1896-1903. -
További szerzők:	Puskás Szilvia (1979-) (neurológus) Bessenyei Mónika (1970-) (neurológus, csecsemő- és gyermekgyógyász) Kovács N. Zs. Spisák Tamás (1986-) (programtervező matematikus, informatikus) Kis Sándor Attila (1973-) (fizikus) Emri Miklós (1962-) (fizikus) Hollódy Katalin (1955-) (csecsemő- és gyermekgyógyász) Fogarasi András Kondákor István (1950-) (neurológus) Fekete István (1951-) (neurológus, pszichiáter)
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001-es BibID:	BIBFORM030126
Első szerző:	Clemens Béla (neurológus)
Cím:	EEG-LORETA endophenotypes of the common idiopathic generalized epilepsy syndromes / B. Clemens, Sz. Puskás, M. Besenyei, M. Emri, G. Opposits, S. A. Kis, K. Hollódy, A. Fogarasi, I. Kondákór, K. Füle, K. Bense, I. Fekete
Dátum:	2012
Megjegyzések:	We tested the hypothesis that the cortical areas with abnormal local EEG synchronization are dissimilar in the three common idiopathic generalized epilepsy (IGE) phenotypes: IGE patients with absence seizures (ABS), juvenile myoclonic epilepsy (JME) and epilepsy with generalized tonic-clonic seizures exclusively (EGTCS). PATIENTS AND METHODS: Groups of unmedicated ABS, JME and EGTCS patients were investigated. Waking EEG background activity (without any epileptiform potentials) was analyzed by a source localization method, LORETA (Low Resolution Electromagnetic Tomography). Each patient group was compared to a separate, age-matched group of healthy control persons. Voxel-based, normalized broad-band (delta, theta, alpha, and beta) and very narrow band (VNB, 1Hz bandwidth, from 1 to 25Hz) LORETA activity (=current source density, A/m(2)) were computed for each person. Group comparison included subtraction (average patient data minus average control data) and group statistics (multiple t-tests, where Bonferroni-corrected p<0.05 values were accepted as statistically significant). RESULTS: Statistically not significant main findings were: overall increased delta and theta broad band activity in the ABS and JME groups; decrease of alpha and beta activity in the EGTCS group. Statistically significant main findings were as follows. JME group: bilaterally increased theta activity in posterior (temporal, parietal, and occipital) cortical areas; bilaterally increased activity in the medial and basal prefrontal area in the 8Hz VNB; bilaterally decreased activity in the precuneus, posterior cingulate and superior parietal lobule in the 11Hz and 21-22Hz VNBs. ABS group: bilaterally increased theta activity emerged in the basal prefrontal and medial temporal limbic areas. Decreased activity was found at 19-21Hz in the right postcentral gyrus and parts of the right superior and medial temporal gyri. EGTCS group: decreased activity was found in the frontal cortex and the postcentral gyrus at 10-11Hz, increased activity in the right parahippocampal gyrus at 16-18Hz. DISCUSSION: Increased theta activity in the posterior parts of the cortex is the endophenotype for JME. Increased theta activity in the fronto-temporal limbic areas is the endophenotype for ABS. Statistically not significant findings might indicate diffuse biochemical abnormality of the cortex in JME and ABS.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk
Megjelenés:	Epilepsy Research. - 99 : 3 (2012), p. 281-292. -
További szerzők:	Puskás Szilvia (1979-) (neurológus) Bessenyei Mónika (1970-) (neurológus, csecsemő- és gyermekgyógyász) Emri Miklós (1962-) (fizikus) Opposits Gábor (1974-) (fizikus, szoftver fejlesztő) Kis Sándor Attila (1973-) (fizikus) Hollódy Katalin (1955-) (csecsemő- és gyermekgyógyász) Fogarasi András Kondákor István (1950-) (neurológus) Füle K. Bense Katalin Fekete István (1951-) (neurológus, pszichiáter)
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001-es BibID:	BIBFORM017054
Első szerző:	Clemens Béla (neurológus)
Cím:	EEG functional connectivity of the intrahemispheric cortico-cortical network of idiopathic generalized epilepsy / Clemens B., Puskás S., Bessenyei M., Emri M., Spisák T., Koselák M., Hollódy K., Fogarasi A., Kondákór I., Füle K., Fekete I.
Dátum:	2011
ISSN:	0920-1211 1872-6844
Megjegyzések:	Intrahemispheric, cortico-cortical EEG functional connectivity (fC) was investigated in untreated patients with idiopathic generalized epilepsy (IGE) in this explorative study. PATIENTS AND METHODS: Group comparison was carried out between 19, drug-naive IGE patients and 19, matched healthy persons. 90x2s of 19 channels waking, interictal background EEG signal (without epileptiform potentials) were processed to the LORETA (low resolution electromagnetic tomography) software to compute current source density for 2394 voxels representing parcels of the cerebral cortex for 25 very narrow bands of 1Hz bandwidth (VNBs) from 1 to 25Hz. EEG fC was investigated among the already localized sources. Pearson correlation coefficients (R) were computed among the 33 regions of interest (ROI) within the left and within the right hemisphere, separately. Group differences were computed by means of t-statistics. Corrected p<0.05 differences were accepted as statistically significant. MAIN RESULTS: (1) The anatomical patterns of the fC differences showed great frequency-dependency. (2) Hemispheric asymmetry was prominent within most VNBs. (3) Decreased fC in the IGE group was found across all VNBs in the 1-6Hz frequency range as compared to mixed patterns comprising both increased and decreased fC at >6Hz frequencies. (4) In the 5-25Hz range, decreased fC dominated in the anterior, increased fC in the posterior parts of the cortex. (5) The results delineated an anterior and a posterior network. DISCUSSION: (1) Decreased fC in the 1-6Hz band might indicate some relationship to yet hidden structure network abnormalities. (2) The anatomical patterns of fC indicate frequency-dependent, pathological coupling and decoupling processes in the interictal state. (3) The two networks might help to understand seizure liability and seizure precipitation in IGE. SIGNIFICANCE: This is the first study to explore EEG fC in the interictal condition of IGE patients. The importance of EEG frequencies in evaluating fC in IGE was demonstrated and starting points for further research were given.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk
Megjelenés:	Epilepsy Research. - 96 : 1-2 (2011), p. 11-23. -
További szerzők:	Puskás Szilvia (1979-) (neurológus) Bessenyei Mónika (1970-) (neurológus, csecsemő- és gyermekgyógyász) Emri Miklós (1962-) (fizikus) Spisák Tamás (1986-) (programtervező matematikus, informatikus) Koselák Mihály (1986-) (informatikus) Hollódy Katalin (1955-) (csecsemő- és gyermekgyógyász) Fogarasi András Kondákor István (1950-) (neurológus) Füle K. Fekete István (1951-) (neurológus, pszichiáter)
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat DOI elektronikus változat
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