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001-es BibID:	BIBFORM100385
035-os BibID:	(cikkazonosító)1235
Első szerző:	Béres András
Cím:	Healing through faith : meeting a chaplain coupled with biblical readings could produce lymphocyte changes that correlate with brain activity (HEALING study) / Béres András, Emri Miklós, Aranyi Csaba, Fajtai Dániel, Nagy Ferenc, Szabó Péter, Bödecs Pál, Hörcsik Edit, Perpékné Papp Éva, Tomanek Ferenc, Kuti Márta, Petőfalviné Ágnes, Kisdeákné Hajnalka, Bíró Gergely, Kovács Dániel, Bakos Bettina, Vinczen Eszter, Gál Eszter, Sillinger Renáta, Szalai Zoltán, Szilágyi Antal, Kiss-Merki Marianna, Nagyéri György, Fodor Judit, Németh Tamás, Papp Erzsébet, Repa Imre
Dátum:	2021
ISSN:	2046-1402
Megjegyzések:	Introduction: Faith and systems of beliefs are known to impact not only the emotional, but also the immunological state of believers in ways that we are just starting to understand. Moreover, clinical implications of previous studies are limited. The aim of the "HEALING" (Hospital-based Ecumenical and Linguistic Immuno-NeuroloGic) Study was to examine immunological and neurological changes in hospitalized patients after meeting a chaplain coupled with biblical readings. Methods: Hospitalized patients were pre-screened to find those who were the most in need of an intervention. A passage from the Bible was read to them during a meeting with the chaplain at the bedside (n= 20) or in the chapel (n= 18). No meeting occurred in the randomized control group (n=19). Blood samples were taken 30 minutes prior, and 60 minutes after the meeting to measure white blood cells (WBC), interferon gamma (IFN-?), immunoglobulin M (IgM), IgA, IgG, and complement 3 (C3). A subgroup of the visited patients was subjected to functional magnetic resonance imaging (fMRI), where they were played an audiotape of readings of the same passage from the Bible (n=21). Results: Lymphocyte counts increased more often after the more successful visits, but the immunological changes were not significant. Conversely, a significant (p fwe =0.003) correlation was revealed between changes in lymphocytes and activation of the angular gyrus (left BA39) during fMRI, a brain area involved in word recognition. Conclusions: Although limited by the sample size and cohort study design, the findings suggest the depth of psycho-immunological changes could depend on the degree to which the chaplains' main message is understood.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk hit pszichoneuroimmunológia ápolás teológia fMRI
Megjelenés:	F1000Research. - 10 (2021), p. 1-20. -
További szerzők:	Emri Miklós (1962-) (fizikus) Aranyi Sándor Csaba (1988-) (programtervező informatikus) Fajtai Dániel Nagy Ferenc (neurológus Kaposvár) Szabó Péter Bödecs Pál Hörcsik Edit Perpékné Papp Éva Tomanek Ferenc Kuti Márta Petőfalviné Ágnes Kisdeákné Hajnalka Biró Gergely Kovács Dániel Bakos Bettina Vinczen Eszter Gál Eszter Sillinger Renáta Szalai Zoltán Szilágyi Antal Kiss-Merki Marianna Nagyéri György Fodor Judit Németh Tamás Papp Erzsébet Repa Imre (1950-) (radiológus)
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001-es BibID:	BIBFORM101524
035-os BibID:	(cikkazonosító)949 (WoS)000801949300001 (Scopus)85129502844
Első szerző:	Borbély Katalin
Cím:	PET/MRI in the Presurgical Evaluation of Patients with Epilepsy: A Concordance Analysis / Borbély Katalin, Emri Miklós, Kenessey István, Tóth Márton, Singer Júlia, Barsi Péter, Vajda Zsolt, Pál Endre, Tóth Zoltán, Beyer Thomas, Dóczi Tamás, Bajzik Gábor, Fabó Dániel, Janszky József, Jordán Zsófia, Fajtai Dániel, Kelemen Anna, Juhos Vera, Wintermark Max, Nagy Ferenc, Moizs Mariann, Nagy Dávid, Lückl János, Repa Imre
Dátum:	2022
ISSN:	2227-9059
Megjegyzések:	The aim of our prospective study was to evaluate the clinical impact of hybrid [18F]-fluorodeoxyglucose positron emission tomography/magnetic resonance imaging ([18F]-FDG PET/MRI) on the decision workflow of epileptic patients with discordant electroclinical and MRI data. A novel mathematical model was introduced for a clinical concordance calculation supporting the classification of our patients by subgroups of clinical decisions. Fifty-nine epileptic patients with discordant clinical and diagnostic results or MRI negativity were included in this study. The diagnostic value of the PET/MRI was compared to other modalities of presurgical evaluation (e.g., electroclinical data, PET, and MRI). The results of the population-level statistical analysis of the introduced data fusion technique and concordance analysis demonstrated that this model could be the basis for the development of a more accurate clinical decision support parameter in the future. Therefore, making the establishment of "invasive" (operable and implantable) and "not eligible for any further invasive procedures" groups could be much more exact. Our results confirmed the relevance of PET/MRI with the diagnostic algorithm of presurgical evaluation. The introduction of a concordance analysis could be of high importance in clinical and surgical decision-making in the management of epileptic patients. Our study corroborated previous findings regarding the advantages of hybrid PET/MRI technology over MRI and electroclinical data.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk PET/MRI epilepsy
Megjelenés:	Biomedicines. - 10 : 5 (2022), p. 1-14. -
További szerzők:	Emri Miklós (1962-) (fizikus) Kenessey István Tóth Márton (1960-) (neurológus) Singer Júlia Barsi Péter Vajda Zsolt Pál Endre Tóth Zoltán Beyer, Thomas Dóczi Tamás Bajzik Gábor (1968-) (orvos) Fabó Dániel Janszky József Jordán Zsófia Fajtai Dániel Kelemen Anna Juhos Vera Wintermark, Max Nagy Ferenc (neurológus Kaposvár) Moizs Marianna (1964-) (orvos) Nagy Dávid Lückl János Repa Imre (1950-) (radiológus)
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001-es BibID:	BIBFORM096996
Első szerző:	Tóth Márton (neurológus)
Cím:	The role of hybrid FDG-PET/MRI on decision-making in presurgical evaluation of drug-resistant epilepsy / Tóth Márton, Barsi Péter, Tóth Zoltán, Borbély Katalin, Lückl János, Emri Miklós, Repa Imre, Janszky József, Dóczi Tamás, Horváth Zsolt, Halász Péter, Juhos Vera, Gyimesi Csilla, Bóné Beáta, Kuperczkó Diána, Horváth Réka, Nagy Ferenc, Kelemen Anna, Jordán Zsófia, Újvári Ákos, Hagiwara Koichi, Isnard Jean, Pál Endre, Fekésházy Attila, Fabó Dániel, Vajda Zsolt
Dátum:	2021
ISSN:	1471-2377
Megjegyzések:	Background: When MRI fails to detect a potentially epileptogenic lesion, the chance of a favorable outcome after epilepsy surgery becomes significantly lower (from 60 to 90% to 20?65%). Hybrid FDG-PET/MRI may provide additional information for identifying the epileptogenic zone. We aimed to investigate the possible effect of the introduction of hybrid FDG-PET/MRI into the algorithm of the decision-making in both lesional and non-lesional drug-resistant epileptic patients. Methods: In a prospective study of patients suffering from drug-resistant focal epilepsy, 30 nonlesional and 30 lesional cases with discordant presurgical results were evaluated using hybrid FDG-PET/MRI. Results: The hybrid imaging revealed morphological lesion in 18 patients and glucose hypometabolism in 29 patients within the nonlesional group. In the MRI positive group, 4 patients were found to be nonlesional, and in 9 patients at least one more epileptogenic lesion was discovered, while in another 17 cases the original lesion was confirmed by means of hybrid FDG-PET/MRI. As to the therapeutic decision-making, these results helped to indicate resective surgery instead of intracranial EEG (iEEG) monitoring in 2 cases, to avoid any further invasive diagnostic procedures in 7 patients, and to refer 21 patients for iEEG in the nonlesional group. Hybrid FDG-PET/MRI has also significantly changed the original therapeutic plans in the lesional group. Prior to the hybrid imaging, a resective surgery was considered in 3 patients, and iEEG was planned in 27 patients. However, 3 patients became eligible for resective surgery, 6 patients proved to be inoperable instead of iEEG, and 18 cases remained candidates for iEEG due to the hybrid FDG-PET/MRI. Two patients remained candidates for resective surgery and one patient became not eligible for any further invasive intervention. Conclusions: The results of hybrid FDG-PET/MRI significantly altered the original plans in 19 of 60 cases. The introduction of hybrid FDG-PET/MRI into the presurgical evaluation process had a potential modifying effect on clinical decision-making.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban folyóiratcikk Drug-resistant epilepsy PET/MRI Hybrid FDG-PET/MRI Clinical decision-making, Preoperative workflow Epilepsy surgery
Megjelenés:	BMC Neurology. - 21 : 1 (2021), p. 1-20. -
További szerzők:	Barsi Péter Tóth Zoltán Borbély Katalin Lückl János Emri Miklós (1962-) (fizikus) Repa Imre (1950-) (radiológus) Janszky József Dóczi Tamás Horváth Zsolt Halász Péter Juhos Vera Gyimesi Csilla Bóné Beáta Kuperczkó Diána Horváth Réka Nagy Ferenc (neurológus Kaposvár) Kelemen Anna Jordán Zsófia Újvári Ákos Hagiwara, Koichi Isnard, Jean Pál Endre Fekésházy Attila Fabó Dániel Vajda Zsolt
Pályázati támogatás:	GINOP-2.3.3-15- 2016-00032 GINOP EFOP-3.6.2-16-2017-00008 EFOP 2017- 1.2.1-NKP-2017-00002 Egyéb
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