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1.

001-es BibID:BIBFORM101524
035-os BibID:(cikkazonosító)949 (WoS)000801949300001 (Scopus)85129502844
Első szerző:Borbély Katalin
Cím:PET/MRI in the Presurgical Evaluation of Patients with Epilepsy: A Concordance Analysis / Borbély Katalin, Emri Miklós, Kenessey István, Tóth Márton, Singer Júlia, Barsi Péter, Vajda Zsolt, Pál Endre, Tóth Zoltán, Beyer Thomas, Dóczi Tamás, Bajzik Gábor, Fabó Dániel, Janszky József, Jordán Zsófia, Fajtai Dániel, Kelemen Anna, Juhos Vera, Wintermark Max, Nagy Ferenc, Moizs Mariann, Nagy Dávid, Lückl János, Repa Imre
Dátum:2022
ISSN:2227-9059
Megjegyzések:The aim of our prospective study was to evaluate the clinical impact of hybrid [18F]-fluorodeoxyglucose positron emission tomography/magnetic resonance imaging ([18F]-FDG PET/MRI) on the decision workflow of epileptic patients with discordant electroclinical and MRI data. A novel mathematical model was introduced for a clinical concordance calculation supporting the classification of our patients by subgroups of clinical decisions. Fifty-nine epileptic patients with discordant clinical and diagnostic results or MRI negativity were included in this study. The diagnostic value of the PET/MRI was compared to other modalities of presurgical evaluation (e.g., electroclinical data, PET, and MRI). The results of the population-level statistical analysis of the introduced data fusion technique and concordance analysis demonstrated that this model could be the basis for the development of a more accurate clinical decision support parameter in the future. Therefore, making the establishment of "invasive" (operable and implantable) and "not eligible for any further invasive procedures" groups could be much more exact. Our results confirmed the relevance of PET/MRI with the diagnostic algorithm of presurgical evaluation. The introduction of a concordance analysis could be of high importance in clinical and surgical decision-making in the management of epileptic patients. Our study corroborated previous findings regarding the advantages of hybrid PET/MRI technology over MRI and electroclinical data.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
PET/MRI
epilepsy
Megjelenés:Biomedicines. - 10 : 5 (2022), p. 1-14. -
További szerzők:Emri Miklós (1962-) (fizikus) Kenessey István Tóth Márton (1960-) (neurológus) Singer Júlia Barsi Péter Vajda Zsolt Pál Endre Tóth Zoltán Beyer, Thomas Dóczi Tamás Bajzik Gábor (1968-) (orvos) Fabó Dániel Janszky József Jordán Zsófia Fajtai Dániel Kelemen Anna Juhos Vera Wintermark, Max Nagy Ferenc (neurológus Kaposvár) Moizs Marianna (1964-) (orvos) Nagy Dávid Lückl János Repa Imre (1950-) (radiológus)
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2.

001-es BibID:BIBFORM090005
Első szerző:Cselik Zsolt
Cím:Predictive value of PET/CT based metabolic information in the modern 3D based radiotherapy treatment of head and neck can-cer patients - single institute study / Zsolt Cselik, Zoltán Tóth, András Kedves, Dávid Sipos, Omar Freihat, Tímea Vecsera, Gábor Lukács, Miklós Emri, Gábor Bajzik, Janaki Hadjiev, Imre Repa, Mariann Moizs, Árpád Kovács
Dátum:2020
Megjegyzések:Objective: The aim of the study was to evaluate the predictive value of pretreatment positron emission tomography (PET) standardized uptake value (SUVmax), standardized uptake value corrected for lean body mass (SULpeak) value, metabolic tumour volume (MTV) and total lesion glycolysis (TLG) parameters of the primary tumour assessed with PET/computed tomography (CT) in the clinical out-come in patients diagnosed with histopathologically confirmed head and neck squamous cell carcinoma. Materials and methods: Retrospective evaluation was performed using PET/CT image datasets of 52 histologically proven head and neck cancer patients in 4 weeks' prior receiving definitive chemo-radiotherapy (CRT). Positron emission tomography /CT was performed before the CRT and 12 weeks after it for response evaluation. Image data was used for target volume delineation and for specify SUVmax, SULpeak, MTV and TLG parameters of the primary tumour. According to the results of the therapeutic response evaluation two patient subgroups were created in relation to the presence or absence of viable tumour. Metabolic data from pre-treatment PET/CT and therapeutic response were correlated using Kruskal-Wallis test. Results: After completion of the CRT in 24/52 (46%) cases viable residual tumour was detected on restaging PET/CT, while in 28/52 (54%) patients showed complete remission. For the therapeutic success prediction assessment, we could not find any significant correlation with pre-treatment SUVmax and SULpeak values (P>0.44, P>0.33). Total lesion glycolysis provided nearly significant difference (P=0.052) and MTV had shown significant difference (P=0.001) between the two patient subgroups statistically. Conclusion: Simple metabolic data (SUVmax and SULpeak) from pretreatment fluorine-18-fluorodeoxyglucose (18F-FDG) PET/CT were unable to predict therapeutic response, while volumetric information containing MTV and TLG parameters proved to be more useful, thus their inclusion to risk stratification may also have additional value.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:Hellenic Journal of Nuclear Medicine. - 23 : 3 (2020), p. 165-171. -
További szerzők:Tóth Zoltán Kedves András Sipos Dávid Freihat, Omar Vecsera Tímea Lukács Gábor Emri Miklós (1962-) (fizikus) Bajzik Gábor (1968-) (orvos) Hadjiev, Janaki Repa Imre (1950-) (radiológus) Moizs Marianna (1964-) (orvos) Kovács Árpád (1979-) (onkoradiológus, klinikai onkológus)
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Intézményi repozitóriumban (DEA) tárolt változat
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3.

001-es BibID:BIBFORM087704
035-os BibID:(cikkazonosító)1484 (WOS)000570425700001 (Scopus)85090955102
Első szerző:Kedves András
Cím:Predictive Value of Diffusion, Glucose Metabolism Parameters of PET/MR in Patients With Head and Neck Squamous Cell Carcinoma Treated With Chemoradiotherapy / Kedves András, Tóth Zoltán, Emri Miklós, Fábián Krisztián, Sipos Dávid, Freihat Omar, Tollár József, Cselik Zsolt, Lakosi Ferenc, Bajzik Gábor, Repa Imre, Kovács Árpád
Dátum:2020
ISSN:2234-943X
Megjegyzések:Purpose: This study aims to evaluate the predictive value of the pretreatment, metabolic, and diffusion parameters of a primary tumor assessed with PET/MR on patient clinical outcomes. Methods: Retrospective evaluation was performed using PET/MR image data sets acquired using the single tracer injection dual imaging of 68 histologically proven head and neck cancer patients 4 weeks before receiving definitive chemoradiotherapy (CRT). PET/MR was performed before the CRT and 12 weeks after the CRT for response evaluation. Image data (PET and MRI diffusion-weighted imaging [DWI]) was used to specify the maximum standard uptake value, the peak lean body mass corrected, SUVmax, the metabolic tumor volume, the total lesion glycolysis (SUVmax, SULpeak, MTV, and TLG), and the mean apparent diffusion coefficient (ADCmean) of the primary tumor. Based on the results of the therapeutic response evaluation, two patient subgroups were created: one with a viable tumor and another without. Metabolic and diffusion data, from the pretreatment PET/MR and the therapeutic response, were correlated using Spearman's correlation coefficient and Wilcoxon's test. Results: After completing the CRT, a viable residual tumor was detected in 36/68 (53%) cases, and 32/68 (47%) patients showed complete remission. However, no significant correlation was found between the pretreatment parameter, ADCmean (p = 0.88), and the therapeutic success. The PET parameters, SUVmax and SULpeak, MTV, and TLG (p = 0.032, p = 0.01, p < 0.0001, p = 0.0004) were statistically significantly different between the two patient subgroups. Kedves et al. Predictive Value of 18F-FDG PET/MR Conclusion: This study found that MRI-based (ADCmean) data from FDG PET/MR pretreatment could not be used to predict therapeutic response although the PET parameters SUVmax, SULpeak, MTV, and TLG proved to be more useful; thus, their inclusion in risk stratification may also be of additional value.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
PET/MR
predictive value
SUV
MTV
TLG
ADC
clinical outcome
squamous cell carcinoma
Megjelenés:Frontiers in Oncology. - 10 (2020), p. 1-11. -
További szerzők:Tóth Zoltán Emri Miklós (1962-) (fizikus) Fábián Krisztián Sipos Dávid Freihat, Omar Tollár József Cselik Zsolt Lakosi Ferenc Bajzik Gábor (1968-) (orvos) Repa Imre (1950-) (radiológus) Kovács Árpád (1979-) (onkoradiológus, klinikai onkológus)
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Intézményi repozitóriumban (DEA) tárolt változat
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4.

001-es BibID:BIBFORM083458
Első szerző:Kedves András
Cím:Predictive value of 18F-FDG PET/CT information in the modern 3D-based radiotherapy treatment of head and neck cancer patients / A. Kedves, Z. Tóth, M. Emri, D. Sípos, V. Koczka, I. Repa, Á. Kovács
Dátum:2019
ISSN:1869-4101
Tárgyszavak:Orvostudományok Klinikai orvostudományok idézhető absztrakt
folyóiratcikk
Megjelenés:Insights into Imaging. - 10 : Suppl. 1 (2019), p. S374. -
További szerzők:Tóth Zoltán Emri Miklós (1962-) (fizikus) Sipos Dávid Koczka V. Repa Imre (1950-) (radiológus) Kovács Árpád (1979-) (onkoradiológus, klinikai onkológus)
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5.

001-es BibID:BIBFORM096996
Első szerző:Tóth Márton (neurológus)
Cím:The role of hybrid FDG-PET/MRI on decision-making in presurgical evaluation of drug-resistant epilepsy / Tóth Márton, Barsi Péter, Tóth Zoltán, Borbély Katalin, Lückl János, Emri Miklós, Repa Imre, Janszky József, Dóczi Tamás, Horváth Zsolt, Halász Péter, Juhos Vera, Gyimesi Csilla, Bóné Beáta, Kuperczkó Diána, Horváth Réka, Nagy Ferenc, Kelemen Anna, Jordán Zsófia, Újvári Ákos, Hagiwara Koichi, Isnard Jean, Pál Endre, Fekésházy Attila, Fabó Dániel, Vajda Zsolt
Dátum:2021
ISSN:1471-2377
Megjegyzések:Background: When MRI fails to detect a potentially epileptogenic lesion, the chance of a favorable outcome after epilepsy surgery becomes significantly lower (from 60 to 90% to 20?65%). Hybrid FDG-PET/MRI may provide additional information for identifying the epileptogenic zone. We aimed to investigate the possible effect of the introduction of hybrid FDG-PET/MRI into the algorithm of the decision-making in both lesional and non-lesional drug-resistant epileptic patients. Methods: In a prospective study of patients suffering from drug-resistant focal epilepsy, 30 nonlesional and 30 lesional cases with discordant presurgical results were evaluated using hybrid FDG-PET/MRI. Results: The hybrid imaging revealed morphological lesion in 18 patients and glucose hypometabolism in 29 patients within the nonlesional group. In the MRI positive group, 4 patients were found to be nonlesional, and in 9 patients at least one more epileptogenic lesion was discovered, while in another 17 cases the original lesion was confirmed by means of hybrid FDG-PET/MRI. As to the therapeutic decision-making, these results helped to indicate resective surgery instead of intracranial EEG (iEEG) monitoring in 2 cases, to avoid any further invasive diagnostic procedures in 7 patients, and to refer 21 patients for iEEG in the nonlesional group. Hybrid FDG-PET/MRI has also significantly changed the original therapeutic plans in the lesional group. Prior to the hybrid imaging, a resective surgery was considered in 3 patients, and iEEG was planned in 27 patients. However, 3 patients became eligible for resective surgery, 6 patients proved to be inoperable instead of iEEG, and 18 cases remained candidates for iEEG due to the hybrid FDG-PET/MRI. Two patients remained candidates for resective surgery and one patient became not eligible for any further invasive intervention. Conclusions: The results of hybrid FDG-PET/MRI significantly altered the original plans in 19 of 60 cases. The introduction of hybrid FDG-PET/MRI into the presurgical evaluation process had a potential modifying effect on clinical decision-making.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Drug-resistant epilepsy
PET/MRI
Hybrid FDG-PET/MRI
Clinical decision-making,
Preoperative workflow
Epilepsy surgery
Megjelenés:BMC Neurology. - 21 : 1 (2021), p. 1-20. -
További szerzők:Barsi Péter Tóth Zoltán Borbély Katalin Lückl János Emri Miklós (1962-) (fizikus) Repa Imre (1950-) (radiológus) Janszky József Dóczi Tamás Horváth Zsolt Halász Péter Juhos Vera Gyimesi Csilla Bóné Beáta Kuperczkó Diána Horváth Réka Nagy Ferenc (neurológus Kaposvár) Kelemen Anna Jordán Zsófia Újvári Ákos Hagiwara, Koichi Isnard, Jean Pál Endre Fekésházy Attila Fabó Dániel Vajda Zsolt
Pályázati támogatás:GINOP-2.3.3-15- 2016-00032
GINOP
EFOP-3.6.2-16-2017-00008
EFOP
2017- 1.2.1-NKP-2017-00002
Egyéb
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Intézményi repozitóriumban (DEA) tárolt változat
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6.

001-es BibID:BIBFORM083496
Első szerző:Tóth Zoltán
Cím:Evaluation of hepatic FDG uptake during lymphoma response assessment PET/CT / Z. Tóth, G. Lukács, P. Rajnics, M. Emri, Zs. Cselik, L. Zilahi, Zs. Gábor, M. Egyed, I. Repa, Á. Kovács
Dátum:2017
ISSN:1506-9680 1644-4345
Tárgyszavak:Orvostudományok Klinikai orvostudományok idézhető absztrakt
folyóiratcikk
Megjelenés:Nuclear Medicine Review. - 20 : 2 (2017), p. 113. -
További szerzők:Lukács Gábor Rajnics Péter Emri Miklós (1962-) (fizikus) Cselik Zsolt Zilahi Lívia Gábor Zsuzsanna Egyed Miklós Repa Imre (1950-) (radiológus) Kovács Árpád (1979-) (onkoradiológus, klinikai onkológus)
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Intézményi repozitóriumban (DEA) tárolt változat
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7.

001-es BibID:BIBFORM083499
Első szerző:Tóth Zoltán
Cím:Predictive role of FDG PET/CT in head and neck cancer treated with radiotherapy : preliminary results / Z. Tóth, G. Lukács, A. Kedves, M. Emri, Zs. Cselik, G. Toller, É. Ferenczy, F. Lakosi, J. Hadjiev, I. Repa, Á. Kovács
Dátum:2017
ISSN:1506-9680 1644-4345
Tárgyszavak:Orvostudományok Klinikai orvostudományok idézhető absztrakt
folyóiratcikk
Megjelenés:Nuclear Medicine Review. - 20 : 2 (2017), p. 113. -
További szerzők:Lukács Gábor Kedves András Emri Miklós (1962-) (fizikus) Cselik Zsolt Toller Gábor L. Ferenczy Éva Lakosi Ferenc Hadjiev, Janaki Repa Imre (1950-) (radiológus) Kovács Árpád (1979-) (onkoradiológus, klinikai onkológus)
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Intézményi repozitóriumban (DEA) tárolt változat
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