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1.

001-es BibID:BIBFORM020469
Első szerző:Csont Tamás
Cím:Direct myocardial anti-ischaemic effect of GTN in both nitrate-tolerant and nontolerant rats : a cyclic GMP-independent activation of KATP / Tamás Csont, Zoltán Szilvássy, Ferenc Fülöp, Saviana Nedeianu, Tibor Páli, Árpád Tósaki, László Dux, Péter Ferdinandy
Dátum:1999
ISSN:0007-1188
Megjegyzések:Abstract1. We have recently demonstrated that glyceryl trinitrate (GTN) exerts a direct myocardial anti-ischaemic effect in both GTN-tolerant and nontolerant rats. Here we examined if this effect is mediated by GTN-derived nitric oxide (NO) and involves guanosine 3'5' cyclic monophosphate (cyclic GMP) and ATP-sensitive K+ channels (KATP). 2. Rats were treated with 100 mg kg-1 GTN or vehicle s.c. three times a day for 3 days to induce vascular GTN-tolerance or nontolerance. Isolated working hearts obtained from either GTN-tolerant or nontolerant rats were subjected to 10 min coronary occlusion in the presence of 10-7 M GTN or its solvent. 3. GTN improved myocardial function and reduced lactate dehydrogenase (LDH) release during coronary occlusion in both GTN-tolerant and nontolerant hearts. 4. Cardiac NO content significantly increased after GTN administration in both GTN-tolerant and nontolerant hearts as assessed by electron spin resonance. However, cardiac cyclic GMP content measured by radioimmunoassay was not changed by GTN administration. 5. When hearts from both GTN-tolerant and nontolerant rats were subjected to coronary occlusion in the presence of the KATP-blocker glibenclamide (10-7 M), the drug itself did not affect myocardial function and LDH release, however, it abolished the anti-ischaemic effect of GTN. 6. We conclude that GTN opens KATP via a cyclic GMP-independent mechanism, thereby leading to an anti-ischaemic effect in the heart in both GTN-tolerant and nontolerant rats.
Tárgyszavak:Orvostudományok Gyógyszerészeti tudományok idegen nyelvű folyóiratközlemény külföldi lapban
Direct myocardial
anti-ischaemic effect
Direct myocardial anti-ischaemic effect
effect of GTN
GTN
cyclic activation of K(ATP)
cyclic GMP-independent activation of K(ATP)
K(ATP)
Megjelenés:British Journal of Pharmacology 128 : 7 (1999), p. 1427-1434. -
További szerzők:Szilvássy Zoltán (1957-) (belgyógyász, farmakológus, klinikai farmakológus) Fülöp Ferenc (Szeged) Nedeianu, Saviana Páli Tibor Tósaki Árpád (1958-) (kísérletes farmakológus, gyógyszerész) Dux László Ferdinándy Péter
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2.

001-es BibID:BIBFORM046569
Első szerző:Ferdinándy Péter
Cím:Nitroglycerin-induced direct protection of the ischaemic myocardium in isolated working hearts of rats with vascular tolerance to nitroglycerin / P. Ferdinandy, Z. Szilvássy, T. Csont, C. Csonka, E. Nagy, M. Koltai, L. Dux
Dátum:1995
ISSN:0007-1188
Megjegyzések:We investigated whether nitroglycerin (NTG) was able to produce an anti-ischaemic effect in isolatedworking hearts of rats with vascular tolerance to NTG. Hearts isolated from tolerant and non-tolerantrats were subjected to 10 min coronary occlusion in the presence of 10r M NTG and/or its solvent. NTGalleviated ischaemia-induced deterioration of cardiac function and decreased lactate dehydrogenaserelease whilst having no effect on coronary flow nor the area of the ischaemic zone both in heartsisolated from NTG-tolerant and non-tolerant rats. The magnitude of the effect was similar in the twogroups. These results suggest that the anti-ischaemic effect of NTG involves direct myocardialmechanisms independent of its vascular action and that vascular tolerance to NTG does not affect thisdirect protective action.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Coronary occlusion
nitroglycerin
nitroglycerin tolerance
cardioprotection;
rat heart
Megjelenés:British Journal of Pharmacology. - 115 : 7 (1995), p. 1129-1131. -
További szerzők:Szilvássy Zoltán (1957-) (belgyógyász, farmakológus, klinikai farmakológus) Csont Tamás Csonka Csaba Nagy Erzsébet (Szeged) Koltai Mátyás Dux László
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3.

001-es BibID:BIBFORM045973
035-os BibID:PMID:12871836
Első szerző:Pórszász Róbert (farmakológus, klinikai farmakológus)
Cím:Hepatic insulin sensitizing substance : a novel 'sensocrine' mechanism to increase insulin sensitivity in anaesthetized rats / Robert Porszasz, Gyorgyi Legvari, Tunde Pataki, Judith Szilvassy, Jozsef Nemeth, Peter Kovacs, Gyorgy Paragh, Janos Szolcsanyi, Zoltan Szilvassy
Dátum:2003
ISSN:0007-1188
Megjegyzések:We recently described the sensory nitrergic nature of the hepatic insulin sensitizing substance (HISS) mechanism linked to postprandial activation of anterior hepatic plexus fibres in rabbits. This study is designed to assess the involvement of the sensory pathways in this mechanism. 2. Selective sensory denervation of the anterior hepatic plexus (AHP) was achieved by a 3-day perineurial treatment with 2% capsaicin solution in Wistar rats (230-250 g). After 1 week, hyperinsulinaemic (100 micro U kg(-1)) euglycaemic (5.5 mmol kg(-1)) glucose clamp studies were performed to estimate insulin sensitivity. 3. The rats with regional AHP sensory denervation exhibited a significantly decreased insulin sensitivity, that is, 9.1+/-1.0 mg kg(-1) min(-1) glucose reinstalled euglycaemia vs 13.3+/-1.9 mg kg(-1) min(-1) glucose (P<0.01) in control rats. 4. Acute partial hepatic denervation by AHP cut was without effect on insulin sensitivity, whereas chronic hepatic denervation induced insulin resistance was similar to that achieved by regional AHP capsaicin treatment. 5. Intraportal administration of L-NAME (10 mg kg(-1)) decreased, whereas capsaicin (0.3 mg kg(-1) min(-1)) increased insulin sensitivity. Neither atropine (1 mg kg(-1)) nor acetylcholine (1-10 micro g mg min(-1)) produced any significant effect. In animals with preceding regional capsaicin desensitization, none of the pharmacological manoeuvres modified the resulting insulin-resistant state. 6. Cysteamine (200 mg kg(-1) s.c.) is known to cause functional somatostatin depletion-induced insulin resistance similar to that produced by either chronic partial hepatic denervation or perineurial AHP capsaicin desensitization. Intraportal capsaicin (0.3 mg kg(-1) min(-1)) was unable to modify insulin resistance achieved by cysteamine. 7. We conclude that capsaicin-sensitive sensory fibres play a crucial role in neurogenic insulin sensitization known as the HISS mechanism without involvement of anatomical reflex-mediated circuits. The results also suggest that HISS is identical to somatostatin of AHP sensory neural origin.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:British Journal of Pharmacology. - 139 : 6 (2003), p. 1171-1179. -
További szerzők:Légvári Györgyi Pataki Tünde (1971-) (farmakológus, klinikai farmakológus) Szilvássy Judit (1960-2022) (fül- orr- gégész) Németh József (Pécs) Kovács Péter (1939-) (farmakológus) Paragh György (1953-) (belgyógyász) Szolcsányi János (Pécs) Szilvássy Zoltán (1957-) (belgyógyász, farmakológus, klinikai farmakológus)
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4.

001-es BibID:BIBFORM099194
035-os BibID:(WOS)000751415800001 (Scopus)85124483518
Első szerző:Priksz Dániel (farmakológus)
Cím:Nicotinic-acid derivative BGP-15 improves diastolic function in a rabbit model of atherosclerotic cardiomyopathy / Priksz Daniel, Lampe Nora, Kovacs Arpad, Herwig Melissa, Bombicz Mariann, Varga Balazs, Wilisicz Tician, Szilvassy Judit, Posa Aniko, Kiss Rita, Gesztelyi Rudolf, Raduly Arnold, Szekeres Reka, Sieme Marcel, Papp Zoltan, Toth Attila, Hamdani Nazha, Szilvassy Zoltan, Juhasz Bela
Dátum:2022
ISSN:0007-1188
Megjegyzések:Background and purpose: Small molecule BGP-15 has been reported to alleviate signs of heart failure and improve muscle function in murine models. Here, we investigated the acute and chronic effects of BGP-15 in a rabbit model of atherosclerotic cardiomyopathy. Experimental approach: Rabbits were maintained on standard chow (Control) or atherogenic diet (HC) for 16 weeks. BGP-15 was administered intravenously (once) or orally (for 16 weeks), to assess acute and chronic effects. Cardiac function was evaluated by echocardiography, endothelium-dependent vasorelaxation was assessed, and key molecules of the protein kinase G (PKG) axis were examined by ELISA and Western blot. Passive force generation was investigated in skinned cardiomyocytes. Key results: Both acute and chronic BGP-15 treatment improved the diastolic performance of the diseased heart, however, vasorelaxation and serum lipid markers were unaffected. Myocardial cGMP levels were elevated in the BGP-15-treated group, along with preserved PKG activity and increased phospholamban Ser16-phosphorylation. PDE5 expression decreased in the BGP-15-treated group, and the substance inhibited PDE1 enzyme. Cardiomyocyte passive tension reduced in BGP-15-treated rabbits, the ratio of titin N2BA/N2B isoforms increased, and PKG-dependent N2B-titin phosphorylation elevated in the BGP-15-treated group. Conclusions and implications: Here we report that BGP-15-treatment improves diastolic function, reduces cardiomyocyte stiffness, and restores titin compliance in a rabbit model of atherosclerotic cardiomyopathy by increasing the activity of the cGMP-PKG axis. As BGP-15 is proven to be safe, it may have clinical value in the treatment of diastolic dysfunction.
Tárgyszavak:Orvostudományok Gyógyszerészeti tudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
BGP-15
diastolic dysfunction
hypercholesterolemia
protein kinase G
titin
Megjelenés:British Journal Of Pharmacology. - 179 : 10 (2022), p. 2240-2258. -
További szerzők:Lampé Nóra Kovács Árpád (1986-) (kardiológus) Herwig, Melissa Bombicz Mariann (1987-) (gyógyszerész) Varga Balázs (1984-) (kísérletes farmakológus) Wilisicz, Tician Szilvássy Judit (1960-2022) (fül- orr- gégész) Pósa Anikó Kiss Rita (1974-) (laboratóriumi diagnosztika szakorvos) Gesztelyi Rudolf (1969-) (kísérletes farmakológus) Ráduly Arnold Péter (1993-) Szekeres Réka (1995-) (orvos) Sieme, Marcel Papp Zoltán (1965-) (kardiológus, élettanász) Tóth Attila (1971-) (biológus) Hamdani, Nazha Szilvássy Zoltán (1957-) (belgyógyász, farmakológus, klinikai farmakológus) Juhász Béla (1978-) (kísérletes farmakológus)
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5.

001-es BibID:BIBFORM046510
Első szerző:Szilvássy Zoltán (belgyógyász, farmakológus, klinikai farmakológus)
Cím:The effect of continuous versus intermittent treatment with transdermal nitroglycerin on pacing-induced preconditioning in conscious rabbits / Z. Szilvassy, P. Ferdinandy, I. Nagy, I. Jakab, M. Koltai
Dátum:1997
ISSN:0007-1188
Megjegyzések:1 Tolerance to the hypotensive e?ect of nitroglycerin (NG) blocks preconditioning induced by rapidventricular pacing (RVP) in rabbits. In the present work the e?ect of continuous versus intermittenttreatment with transdermal nitroglycerin on the pacing-induced preconditioning phenomenon wasstudied in conscious rabbits.2 RVP (500 beats min71 over 5 min) increased left ventricular end-diastolic pressure (LVEDP) frombaseline 4.1+0.9 to postpacing 13.8+2.9 mmHg (P50.001) with a right intraventricular ST-segmentelevation of 1.25+0.13 mV, two indicators of myocardial ischaemia. These changes were signi?cantlyattenuated when the RVP period was preceded by a preconditioning pacing of the same rate andduration with an interpacing interval of 5 min.3 Protection by preconditioning was abolished when the animals had been made tolerant to thevasodilator e?ect of 30 mg kg71 NG by the application of transdermal NG (approx. 0.07 mg kg71 h71)over 7 days. Furthermore, transdermal NG per se attenuated both RVP-induced ST-segment elevationand LVEDP-increase over the 7 day period.4 With intermittent transdermal NG treatment (12 h 'patch on' vs 'patch o?'), neither development ofvascular tolerance nor attenuation of the NG- or preconditioning-induced anti-ischaemic e?ects wereobserved. However, the severity of pacing-induced myocardial ischaemia was signi?cantly increasedduring the 'patch o?' periods.5 In a second set of experiments, postpacing changes in cardiac cyclic GMP and cyclic AMP levelswere determined by means of radioimmunoassay in chronically instrumented anaesthetized open-chestrabbits with the same NG-treatment protocols. Preconditioning reduced postpacing increase in cyclicAMP with an increase in cyclic GMP concentrations in hearts of the untreated animals and in thosegiven patches intermittently during both 'patch on' and 'patch o?' periods. However, the preconditioninge?ect on either cyclic nucleotide was blocked in the tolerant animals.6 Transdermal NG increased resting levels of both cardiac cyclic nucleotides in the non-tolerant butnot in the tolerant state. The postpacing increase in cyclic AMP content was inhibited by transdermalNG, independent of vascular tolerance development, whereas, an increase in cyclic GMP content wasexclusively seen in the non-tolerant animals.7 We conclude that the anti-ischaemic effect of NG is independent of the cyclic GMP mechanism in thetolerant state. While intermittent NG therapy prevents development of vascular tolerance and preservespreconditioning, the nitrate-free periods yield an increased susceptibility of the heart to ischaemicchallenges.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Ischaemic preconditioning
nitrate tolerance
rapid pacing
cyclic GMP
intermittent nitrate therapy
Megjelenés:British Journal of Pharmacology. - 121 : 3 (1997), p. 491-496. -
További szerzők:Ferdinándy Péter Nagy I. Jakab Ildikó (farmakológus) Koltai Mátyás
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6.

001-es BibID:BIBFORM037828
035-os BibID:PMID:7952889
Első szerző:Szilvássy Zoltán (belgyógyász, farmakológus, klinikai farmakológus)
Cím:Loss of preconditioning in rabbits with vascular tolerance to nitroglycerin / Z. Szilvassy, P. Ferdinandy, P. Bor, I. Jakab, J. Szilvassy, I. Nagy, J. Lonovics, M. Koltai
Dátum:1994
ISSN:0007-1188
Megjegyzések:A preceding right ventricular overdrive pacing (VOP) of 500 b.p.m. for 5 min, markedly reduced the severity of global myocardial ischaemia produced by a subsequent 5-min VOP in conscious rabbits. This VOP-induced preconditioning developed in parallel with an increase in cardiac cyclic guanosine 3':5'-monophosphate (cyclic GMP) content. VOP-induced preconditioning was abolished when the animals had been made tolerant to the vasodilator effect of nitroglycerin (NG). In the heart of the NG-tolerant rabbits, neither VOP nor preconditioning increased cyclic GMP content. This suggests that changes by NG tolerance of cyclic GMP metabolism may account for the loss of VOP-induced preconditioning.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Ischaemic preconditioning
nitroglycerin tolerance
cyclic GMP
ST-segment elevation
LVEDP
rabbit heart
egyetemen (Magyarországon) készült közlemény
Megjelenés:British Journal of Pharmacology. - 112 : 4 (1994), p. 999-1001. -
További szerzők:Ferdinándy Péter Bor P. Jakab Ildikó (farmakológus) Szilvássy Judit (1960-2022) (fül- orr- gégész) Nagy István Lonovics János (Szeged) Koltai Mátyás
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