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001-es BibID:	BIBFORM046573
035-os BibID:	PMID:832479
Első szerző:	Szekeres László
Cím:	Moderate stress by cardiac pacing may induce both short term and long term cardioprotection / László Szekeres, Julius Gy. Papp, Zoltán Szilvassy, Éva Udvary, Ágnes Vegh
Dátum:	1993
ISSN:	0008-6363
Megjegyzések:	Objective: The aim was to investigate whether moderate ischaemic stress induced by brief periods of cardiac pacing to twice the normal heart rate protects the heart from the electrophysiological and haemodynamic consequences of subsequent periods of rapid pacing. Methods: Conscious rabbits with implanted right ventricular electrodes and a permanent catheter in the left ventricular cavity were studied. Hearts were paced at a rate of 500?min?1 for 5 min. The resulting transient ST segment elevation in the intracavital electrogram, the ventricular effective refractory period, and the left ventricular end diastolic pressure were measured. Results: After discontinuation of pacing, a shortlasting ST segment elevation appeared in the endocardial electrogram, together with a transient rise in left ventricular end diastolic pressure. These changes were significantly reduced after a second pacing, provided that this was applied not later than 30 min after the first pacing; maximum protection occurred when there was a 5 min interval between these pacing periods. Serial stimulation (10 pacing periods with a 5 min interval between each) gave a similar protection to that resulting from a single pacing period. The protection was lost after 1 h; however, 24 h and 48 h (but not 72 h) after the end of serial stimulation there was again a reduction in postpacing ST segment and left ventricular end diastolic pressure elevation. At these times the ventricular effective refractory period was prolonged. The cyclo-oxygenase inhibitor sodium meclofenamate (1-2 mg?kg?1) prevented the early protection. Conclusions: The results suggest that brief periods of rapid pacing induce both short term and long term cardioprotection, as shown by reduced electrophysiological and haemodynamic consequences of subsequent pacing periods. Endogenous prostanoids might play a role in the short term cardioprotection.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban ventricular overpacing ischemia short term cardioprotection long term cardioprotection
Megjelenés:	Cardiovascular Research. - 27 : 4 (1993), p. 593-596. -
További szerzők:	Papp Gy. Julius (Szeged) Szilvássy Zoltán (1957-) (belgyógyász, farmakológus, klinikai farmakológus) Udvary Éva Végh Ágnes
Internet cím:	Szerző által megadott URL Intézményi repozitóriumban (DEA) tárolt változat
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