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1.

001-es BibID:BIBFORM020345
Első szerző:Bajza Ágnes (biológus)
Cím:Development of insulin resistance by nitrate tolerance in conscious rabbits / Ágnes Bajza, Barna Peitl, József Nemeth, Róbert Porszasz, György Rabloczky, Péter Literati-Nagy, Judit Szilvassy, Zoltán Szilvassy
Dátum:2004
Megjegyzések:Clinical evidence has been raised to suggest that transdermal nitroglycerin increases the sensitivity of peripheral tissues to the hypoglycemic effect of insulin. In this study we determined whether development of tolerance to the hypotensive effect of nitroglycerin also resulted in tolerance to the insulin-sensitizing effect in rabbits. Intravenous glucose disposal and hyperinsulinemic euglycemic glucose clamp studies were performed on naive and hemodynamic nitrate tolerant conscious New Zealand white rabbits. These rabbits were exposed to continuous "patch on" with nitroglycerin (0.07 mg/kg/h) or placebo patches over 7 days. Nitroglycerin treatment of 7 days produced a lack of hypotensive response to a single intravenous bolus of 30 microg/kg nitroglycerin, which caused a significant decrease in mean arterial blood pressure in control rabbits. A six-hour exposure to transdermal nitroglycerin significantly increased insulin sensitivity determined by hyperinsulinemic (100 microU/ml) euglycemic (5.5 mmol/l) glucose clamping as compared with that seen in rabbits treated with placebo patches. A significant decrease in insulin sensitivity was observed in the nitroglycerin patch-treated animals both in the presence and after the removal of the last patch when the patches were applied over 7 days. We conclude that acutely nitrate patches improve insulin sensitivity whereas a 7-day chronic treatment schedule that results in hemodynamic nitrate tolerance also produces insulin resistance.
Tárgyszavak:Orvostudományok Gyógyszerészeti tudományok idegen nyelvű folyóiratközlemény külföldi lapban
insulin tolerance
nitrate tolerance
Megjelenés:Journal of Cardiovascular Pharmacology. - 43 : 3 (2004), p. 471-476. -
További szerzők:Peitl Barna (1972-) (orvos, farmakológus) Németh József (Pécs) Pórszász Róbert (1965-) (farmakológus, klinikai farmakológus) Rablóczky György Literati Nagy Péter Szilvássy Judit (1960-2022) (fül- orr- gégész) Szilvássy Zoltán (1957-) (belgyógyász, farmakológus, klinikai farmakológus)
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2.

001-es BibID:BIBFORM020306
Első szerző:Djazayeri, Katayoun
Cím:Accelerated recovery of 5-fluorouracil-damaged bone marrow after rosiglitazone treatment / Katayoun Djazayeri, Zoltán Szilvássy, Barna Peitl, József Németh, László Nagy, Attila Kiss, Boglárka Szabó, Ilona Benkő
Dátum:2005
Megjegyzések:AbstractOur preliminary data indicate that rosiglitazone may be myeloprotective. We investigated whether it can modify bone marrow recovery. Five-day pre-treatment with rosiglitazone significantly accelerated recovery of 5-fluorouracil-damaged bone marrow in mice. Frequency and femoral content of granulocyte-macrophage progenitors reached mean baseline faster in pre-treated groups than in 5-fluorouracil-treated controls. Consequently, neutropenia was milder. Five-day insulin pre-treatment had similar effects in vivo. Insulin supports in vitro hematopoiesis. The observed myeloprotection demonstrated the importance of insulin in vivo. Clinical use of insulin to moderate myelotoxicity is impractical but rosiglitazone, an insulin sensitizer, could offer hope. Although rosiglitazone tends to increase plasma insulin levels, the significant myeloprotection was partly due to direct effects on progenitors. In vitro rosiglitazone enhanced the survival of both murine progenitor and human mobilized blood stem cells in the presence of 5-fluorouracil, the effect of which was neutralized by a peroxisome-proliferator-activated receptor-gamma antagonist.
Tárgyszavak:Orvostudományok Gyógyszerészeti tudományok idegen nyelvű folyóiratközlemény külföldi lapban
5-fluorouracil
5-fluorouracil-damaged
bone marrow
rosiglitazone
Megjelenés:European Journal of Pharmacology. - 522 : 1-3 (2005), p. 122-129. -
További szerzők:Peitl Barna (1972-) (orvos, farmakológus) Németh József (Pécs) Nagy László (1966-) (molekuláris sejtbiológus, biokémikus) Kiss Attila (1942-) (belgyógyász, haematológus) Szabó Boglárka Benkő Ilona (1954-) (orvos, farmakológus) Szilvássy Zoltán (1957-) (belgyógyász, farmakológus, klinikai farmakológus)
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3.

001-es BibID:BIBFORM019120
Első szerző:Horváth Péter
Cím:Decreased sensory neuropeptide release in isolated bronchi of rats with cisplatin-induced neuropathy / Peter Horvath, Judit Szilvassy, Jozsef Nemeth, Barna Peitl, Maria Szilasi, Zoltan Szilvassy
Dátum:2005
ISSN:0014-2999
Megjegyzések:We studied if attenuated neurogenic bronchoconstriction was associated with a change in sensory neuropeptide release in preparations from rats with cisplatin-induced neuropathy. Electrical field stimulation (100 stimuli, 20 V, 0.1 ms, 20 Hz) induced an increase in the release of somatostatin, calcitonin gene-related peptide (CGRP) and substance P determined by radioimmunoassay from baseline 0.18+/-0.01, 0.17+/-0.01 and 0.86+/-0.02, to 0.59+/-0.02, 1.77+/-0.04 and 5.96 fmol/mg wet tissue weight, respectively, in organ fluid of tracheal tubes from rats. This was significantly attenuated to post-stimulation values of 0.36+/-0.02, 0.45+/-0.02, 4.68+/-0.24 fmol/mg wet tissue weight for somatostatin, CGRP, and substance P, respectively, with a significant decrease in field stimulation-induced contraction of bronchial preparations from animals 11 days after a 5-day treatment period with cisplatin (1.5 mg/kg i.p. once a day). The cisplatin-treated animals developed sensory neuropathy characterized by a 40% decrease in femoral nerve conduction velocity. The results show that a decrease in tracheo-bronchial sensory neuropeptide release associates with feeble bronchomotor responses in rats with cisplatin-induced sensory neuropathy.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
neuropeptide
neuropeptide release
bronchi
cisplatin-induced neuropathy
Megjelenés:European Journal Of Pharmacology 507 : 1-3 (2005), p. 247-252. -
További szerzők:Szilvássy Judit (1960-2022) (fül- orr- gégész) Németh József (Pécs) Peitl Barna (1972-) (orvos, farmakológus) Szilasi Mária (1953-) (tüdőgyógyász, klinikai immunológus, allergológus, belgyógyász) Szilvássy Zoltán (1957-) (belgyógyász, farmakológus, klinikai farmakológus)
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4.

001-es BibID:BIBFORM020318
Első szerző:Jakab Balázs (Pécs)
Cím:Distribution of PACAP-38 in the central nervous system of various species determined by a novel radioimmunoassay / Balázs Jakab, Dóra Reglődi, Rita Józsa, Tibor Hollósy, Andrea Tamás, Andrea Lubics, István Lengvári, Gábor Oroszi, Zoltán Szilvássy, János Szolcsányi, József Németh
Dátum:2004
Megjegyzések:AbstractPituitary adenylate cyclase activating polypeptide (PACAP) occurs in two molecular forms: PACAP-38 and PACAP-27. Soon after the isolation and chemical characterization of PACAP, the first radioimmunoassay (RIA) methods have been developed, but it is a still rarely used laboratory technique in the field of PACAP research. The aim of the present study was to develop a novel, highly specific PACAP-38 assay to investigate the quantitative distribution of PACAP-38 in the central nervous system of various vertebrate species under the same technical and experimental conditions. Different areas of the brain and the spinal cord were removed from rats, chickens and fishes and the tissue samples were processed for PACAP-38 RIA. Our results indicate that the antiserum used in the RIA is C-terminal specific, without affinity for other members of the vasoactive intestinal polypeptide (VIP)/secretin/glucagon peptide family. The average ID50 value was 48.6+/-3.4 fmol/ml determined in 10 consecutive assays. Detection limit for PACAP-38 proved to be 2 fmol/ml. PACAP-38 immunoreactivity was present in the examined brain areas of each species studied, with highest concentration in the rat diencephalons. High levels of PACAP-38 were also detected in the rat telencephalon, followed by spinal cord and brainstem. The central nervous system of the fish also contained considerable concentrations of PACAP-38, whereas lowest concentrations were measured in the central nervous system of the chicken.
Tárgyszavak:Orvostudományok Gyógyszerészeti tudományok idegen nyelvű folyóiratközlemény külföldi lapban
PACAP-38
central nervous system
radioimmunoassay
Megjelenés:Journal of Biochemical and Biophysical Methods. - 61 : 1-2 (2004), p. 189-198. -
További szerzők:Reglődi Dóra (Idegtudományok) Józsa Rita (Pécs) Hollósy Tibor (Pécs) Tamás Andrea (Idegtudomány) (Pécs) Lubics Andrea (Pécs) Lengvári István Oroszi Gábor (Pécs) Szolcsányi János (Pécs) Németh József (Pécs) Szilvássy Zoltán (1957-) (belgyógyász, farmakológus, klinikai farmakológus)
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5.

001-es BibID:BIBFORM020462
Első szerző:Kovács Péter (belgyógyász, kardiológus, klinikai farmakológus)
Cím:Effect of transdermal nitroglycerin on glucose-stimulated insulin release in healthy male volunteers / P. Kovacs, Z. Szilvassy, P. Hegyi, J. Nemeth, P. Ferdinandy, Á. Tosaki
Dátum:2000
ISSN:0014-2972
Megjegyzések:Morpholinosydnonimine, a nitric oxide (NO) donor, has been reported to inhibit insulin release in isolated pancreatic islets. We studied whether transdermal application of nitroglycerin, another NO donor widely used for angina prophylaxis, influenced glucose-stimulated insulin release in healthy, young, male volunteers.METHODS AND RESULTS:Oral glucose tolerance tests [(OGTT) 75 g glucose in 200 mL of water) were performed in the presence of placebo patches or nitroglycerin-releasing 'active' patches (approx. 0.4 mg hour-1 nitroglycerin) in the same patients with a 2-week intertest interval. Venous blood samples were taken before and 15, 30, 60, 90, 120 and 180 min after the glucose load and evaluated for plasma glucose level and immunoreactive insulin responses (radioimmunoassay). Glucose-stimulated maximum increase in plasma insulin immunoreactivity were 36.3 +/- 5 and 78.8 +/- 6.1 mU mL-1 (P < 0.05) in the presence of active and placebo patches, respectively. Nevertheless, both fasting and postload blood glucose levels were the same at either patch. Active patches significantly decreased blood pressure with a marginal increase in heart rate.CONCLUSION:We conclude that inhibition of glucose-stimulated insulin release by transdermal nitroglycerin without causing hyperglycaemia may serve as a novel component of the antianginal mechanism of action of nitrates.
Tárgyszavak:Orvostudományok Gyógyszerészeti tudományok idegen nyelvű folyóiratközlemény külföldi lapban
transdermal nitroglycerin
glucose-stimulated insulin
Effect of transdermal nitroglycerin
Megjelenés:European Journal Of Clinical Investigation 30 : 1 (2000), p. 41-44. -
További szerzők:Szilvássy Zoltán (1957-) (belgyógyász, farmakológus, klinikai farmakológus) Hegyi Péter Jenő (belgyógyász) Németh József (Pécs) Ferdinándy Péter Tósaki Árpád (1958-) (kísérletes farmakológus, gyógyszerész)
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6.

001-es BibID:BIBFORM030657
Első szerző:Németh József (Pécs)
Cím:Preparation of mono-125I-labelled gastrin-17 for radioimmunoassay measurements / J. Nemeth, M. Vecsernyes, G. Oroszi, Zs. Balla, Zs. Helyes, B. Farkas, Z. Szilvássy
Dátum:2000
Megjegyzések:In the present work the efficiency of two oxidising agents (chloramine-T and iodogen) for human gastrin-17 labelling is investigated, whilst the purification of ion-exchange chromatography is compared with that of reversed-phase HPLC. In the Iodogen method the extent of radioactive iodine incorporation can be as high as 95-98% in contrast to 60-65% attained using the chloramine-T method. Reversed-phase HPLC purification proved to be superior to ion-exchange chromatography on the basis of a more distinct separation of mono-iodinated gastrin underlain by specific activity value (73 to 75 TBq/mmol) near identical with the theoretical one.
Tárgyszavak:Orvostudományok Gyógyszerészeti tudományok idegen nyelvű folyóiratközlemény külföldi lapban
iodination
human gastrin-17
iodogen
chloramine-T
HPLC
ion-exchange chromatography
egyetemen (Magyarországon) készült közlemény
Megjelenés:Journal Of Labelled Compounds & Radiopharmaceuticals 43 : 9 (2000), p. 855-863. -
További szerzők:Vecsernyés Miklós (1959-) (gyógyszertechnológus, endokrinológus) Oroszi Gábor (Pécs) Balla Zsolt Helyes Zsuzsanna Farkas B. Szilvássy Zoltán (1957-) (belgyógyász, farmakológus, klinikai farmakológus)
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7.

001-es BibID:BIBFORM020522
Első szerző:Németh József (Pécs)
Cím:Decreased sensory neuropeptide release from trachea of rats with streptozotocin-induced diabetes / Joseph Nemeth, Zoltan Szilvassy, Martha Than, Gabor Oroszi, Reka Sari, Janos Szolcsanyi J.
Dátum:2000
Megjegyzések:We studied the release of somatostatin, calcitonin gene-related peptide (CGRP) and substance P in response to electrical field stimulation from isolated tracheas of rats following 4 weeks of streptozotocin (50 mg/kg i.v.)-induced diabetes. Field stimulation (40 V, 0.1 ms, 10 Hz for 120 s) increased the release of somatostatin, CGRP and substance P from the baseline 0.18+/-0.029, 0.17+/-0.027, and 1.77+/-0.086 to 0.51+/-0.022, 0.69+/-0.115, and 5.96+/-0.377 in control preparations and 0.31+/-0.081, 0.41+/-0.142, and 3.14+/-0.443 fmol/mg wet tissue weight in preparations from diabetic rats as measured by radioimmunoassay (control vs. diabetic P<0.01 for each). The results show a simultaneous decrease in release of the three sensory neuropeptides and an enhanced plasma somatostatin level in rats with streptozotocin-induced diabetes.
Tárgyszavak:Orvostudományok Gyógyszerészeti tudományok idegen nyelvű folyóiratközlemény külföldi lapban
neuropeptide release
trachea
streptozotocin-induced
streptozotocin-induced diabetes
Megjelenés:European Journal of Pharmacology. - 369 : 2 (1999), p. 221-224. -
További szerzők:Thán Márta Oroszi Gábor (Pécs) Sári Réka (farmakológus) Szolcsányi János (Pécs) Szilvássy Zoltán (1957-) (belgyógyász, farmakológus, klinikai farmakológus)
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8.

001-es BibID:BIBFORM020464
Első szerző:Németh József (Pécs)
Cím:Impairment of neurogenic inflammatory and anti-inflammatory responses in diabetic rats / József Németh, Márta Thán, Réka Sári, Barna Peitl, Gábor Oroszi, Beatrix Farkas, János Szolcsányi, Zoltán Szilvássy
Dátum:1999
Megjegyzések:AbstractThe effect was studied of a primary (preconditioning) neurogenic inflammatory challenge induced by electrical stimulation of the peripheral stump of the sciatic nerve (20 V, 0.5 ms, 5 Hz, for 5 min) on neurogenic oedema (5 min later) induced by stimulation of the contralateral sciatic nerve. Plasma extravasation due to the second stimulation was decreased by 52.7+/-3.1% (P<0.01) in normal animals and by 29.7+/-2.2 and 18.1+/-1.5% with 50 mg/kg streptozotocin pretreatment i.v. 4 and 8 weeks previously, respectively. Subsequently, bilateral sciatic nerve stimulation increased baseline plasma somatostatin levels from 6.4+/-0.3, 11. 7+/-1.4, and 16.8+/-3.8 to 28.3+/-2.9 (P<0.01), 17.9+/-3.7, and 25. 1+/-1.7 pmol/l in normal, and 4- and 8-week diabetic animals, respectively. We conclude that experimental diabetes impairs the capability of a preconditioning neurogenic inflammatory episode to elicit a systemic anti-inflammatory effect. This is accompanied by a deficiency in elevation of the plasma somatostatin level in response to nerve stimulation, although the baseline plasma somatostatin level increases proportionally to the duration of experimental diabetes.
Tárgyszavak:Orvostudományok Gyógyszerészeti tudományok idegen nyelvű folyóiratközlemény külföldi lapban
neurogenic inflammatory
neurogenic inflammatory responses
anti-inflammatory
anti-inflammatory responses
Megjelenés:European Journal of Pharmacology. - 386 : 1 (1999), p. 83-88. -
További szerzők:Thán Márta Sári Réka (farmakológus) Peitl Barna (1972-) (orvos, farmakológus) Oroszi Gábor (Pécs) Farkas Beatrix Szolcsányi János (Pécs) Szilvássy Zoltán (1957-) (belgyógyász, farmakológus, klinikai farmakológus)
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9.

001-es BibID:BIBFORM020389
Első szerző:Németh József (Pécs)
Cím:Impaired capsaicin-induced decrease in heart rate and coronary flow in isolated heart of diabetic rats / J. Németh, Z. Szilvássy, G. Oroszi, R. Pórszász, B. Jakab, J. Szolcsányi
Dátum:2001
ISSN:1588-2683
Megjegyzések:AbstractThe effect of capsaicin (0.1 microM) on heart rate and coronary flow was studied in Langendorff-perfused heart from streptozotocin-induced (50 mg/kg i.v.) diabetic rats where sensory neuropathy developed. In hearts from animals 4- and 8-week diabetes baseline heart rate and coronary flow decreased from 317.9 +/- 2.9 b.p.m. and 13.4 +/- 0.7 m/min to 255.1 +/- 12.7 and 219.8 +/- 2.8 b.p.m. and 8.9 +/- 0.6 and 10.0 +/- 0.1 ml/min (P<0.05), respectively. Capsaicin significantly decreased both variables in either normal or 4-week diabetic animals its effects, however, on coronary flow or heart rate were missing in preparations from 8-week diabetic rats. Endothelin-1 (0.1 nM), the putative mediator of the capsaicin effect, significantly decreased heart rate and coronary flow irrespective of the presence or absence of diabetes. In the femoral nerve of streptozotocin-treated animals conduction velocity involving both fast conducting A- and slow-conducting C-fibres was decreased proportional to the duration of the pre-existing diabetic state. It is concluded that in insulin deficient diabetes the diminished responses evoked by capsaicin on heart rate and coronary flow are signs of sensory neuropathy. This is related to a feeble endothelin release from sensory nerve endings without changes in post-receptor mechanisms mediating the endothelin effects.
Tárgyszavak:Orvostudományok Gyógyszerészeti tudományok idegen nyelvű folyóiratközlemény hazai lapban
Impaired capsaicin-induced
decrease in heart rate
coronary flow
decrease in coronary flow
Megjelenés:Acta Physiologica Hungarica. - 88 : 3-4 (2001), p. 207-218. -
További szerzők:Szilvássy Zoltán (1957-) (belgyógyász, farmakológus, klinikai farmakológus) Oroszi Gábor (Pécs) Pórszász Róbert (1965-) (farmakológus, klinikai farmakológus) Jakab Balázs (Pécs) Szolcsányi János (Pécs)
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10.

001-es BibID:BIBFORM020377
Első szerző:Németh József (Pécs)
Cím:Role of voltage-gated cation channels and axon reflexes in the release of sensory neuropeptides by capsaicin from isolated rat trachea / József Németh, Zsuzsanna Helyes, Gábor Oroszi, Balázs Jakab, Erika Pintér, Zoltán Szilvássy, János Szolcsányi
Dátum:2003
Megjegyzések:AbstractIn order to reveal the role of axon reflexes and sensory receptors in sensory neuropeptide release in response to capsaicin, liberation of substance P, calcitonin gene-related peptide and somatostatin from isolated rat tracheae was investigated in the presence of voltage-sensitive Na(+) and Ca(2+) channel blocking agents. Neuropeptide release induced by capsaicin (10 nM) remained unchanged in the presence of 25 mM lidocaine, 1 microM tetrodotoxin or the N-type Ca(2+) channel inhibitor, omega-conotoxin GVIA (100-300 nM). Peptide release by 100 pulses of 2 Hz field stimulation was prevented by lidocaine or tetrodotoxin. Omega-agatoxin TK (250 nM) significantly inhibited and Cd(2+) (200 microM) prevented capsaicin-induced neuropeptide release. These results suggest that chemical stimulation-induced neuropeptide release does not involve activation of fast Na(+) channels or N- and P-type voltage-dependent Ca(2+) channels, but contribution of Q-type Ca(2+) channels is possible. Sensory neuropeptides are released by capsaicin from sensory receptors without axon reflexes.
Tárgyszavak:Orvostudományok Gyógyszerészeti tudományok idegen nyelvű folyóiratközlemény külföldi lapban
voltage-gated cation
axon reflexes
sensory neuropeptides
capsaicin
Megjelenés:European Journal of Pharmacology. - 458 : 3 (2003), p. 313-318. -
További szerzők:Helyes Zsuzsanna Oroszi Gábor (Pécs) Jakab Balázs (Pécs) Pintér Erika Szolcsányi János (Pécs) Szilvássy Zoltán (1957-) (belgyógyász, farmakológus, klinikai farmakológus)
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11.

001-es BibID:BIBFORM020518
Első szerző:Oroszi Gábor (Pécs)
Cím:Interplay between nitric oxide and CGRP by capsaicin in isolated guinea-pig heart / Gabor Oroszi, Zoltan Szilvassy, Joseph Nemeth, Arpad Tosaki, Janos Szolcsanyi
Dátum:1999
ISSN:1043-6618
Megjegyzések:AbstractCapsaicin at a concentration of 10(-7)m induced a significant increase in heart rate and increased coronary flow in isolated Langendorff-perfused guinea-pig hearts. This effect was completely blocked by 30 microm of N(omega)-nitro-L-arginine methyl ester (L-NAME), an inhibitor of nitric oxide synthase. Additional incubation with 3 m m L-Arg antagonized the inhibitory effect of L-NAME. In the presence of 1 microm of a human calcitonin gene-related peptide fragment (hCGRP 8-37), a CGRP-receptor antagonist, L-Arg was without effect. We conclude that a capsaicin-induced increase in coronary flow and heart rate is dependent from an interplay between CGRP and NO in guinea-pig hearts. 1999 Academic Press.
Tárgyszavak:Orvostudományok Gyógyszerészeti tudományok idegen nyelvű folyóiratközlemény külföldi lapban
nitric oxide
CGRP
capsaicin
Megjelenés:Pharmacological Research 40 : 2 (1999), p. 125-128. -
További szerzők:Szilvássy Zoltán (1957-) (belgyógyász, farmakológus, klinikai farmakológus) Németh József (Pécs) Tósaki Árpád (1958-) (kísérletes farmakológus, gyógyszerész) Szolcsányi János (Pécs)
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12.

001-es BibID:BIBFORM046502
Első szerző:Pálvölgyi Attila
Cím:Interplay between nitric oxide and VIP in CCK-8-induced phasic contractile activity in the rabbit sphincter of Oddi / Attila Pálvölgyi, Réka Sári, József Németh, Annamária Szabolcs, István Nagy, Péter Hegyi, János Lonovics, Zoltán Szilvássy
Dátum:2005
ISSN:1007-9327
Megjegyzések:AIM: The sphincter of Oddi (SO) plays an important role indelivery of bile into the duodenum. To establish whethervasoactive intestinal polypeptide (VIP) and nitric oxide (NO)were involved in phasic contractile activity of the rabbitSO stimulated by cholecystokinin-octapeptide (CCK-8).METHODS: Isolated SO muscle rings were cleaned of fatand mounted horizontally on two small L-shaped hooksone of which was connected to a force transducer for themeasurement of isometric tension. The experiments werecarried out in a thermostatically controlled (37?0.2 )organ bath (5 mL) containing Krebs solution. The organfluid was gassed with 95% O2 and 50 mL/L CO2 to keepthe pH at 7.40?0.05. Contractile responses to CCK-8(1 ?mol/L) were evaluated in the presence and absenceof NG-nitro-L-arginine (LNNA), an inhibitor of NO synthase(100 ?mol/L), and (p-chloro-D-Phe6-Leu17)-VIP (VIPa,30 ?mol/L), a VIP receptor antagonist.RESULTS: CCK-8 stimulated the phasic activity of the SO.NO synthase inhibition increased the frequency and amplitudeof contractions with a slight increase in developed tension.Pre-incubation with VIPa also attenuated this CCK-8 effect.The combined application of LNNA and VIPa abolishedthe phasic activity of the muscle rings with a marked increasein tension in response to CCK-8.CONCLUSION: VIP and NO together contribute to anincrease in phasic activity of SO.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Sphincter of Oddi
CCK
VIP
NO
LNNA
Megjelenés:World Journal of Gastroenterology. - 11 : 21 (2005), p. 3264-3266. -
További szerzők:Sári Réka (farmakológus) Németh József (Pécs) Szabolcs Annamária Nagy István Hegyi Péter Jenő (belgyógyász) Lonovics János (Szeged) Szilvássy Zoltán (1957-) (belgyógyász, farmakológus, klinikai farmakológus)
Pályázati támogatás:3.2.2.-2004-07-0001/3.0
GVOP
Internet cím:Szerző által megadott URL
Intézményi repozitóriumban (DEA) tárolt változat
Borító:
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