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001-es BibID:BIBFORM046509
035-os BibID:PMID:9236151
Első szerző:Szekeres László
Cím:Delayed cardiac protection against harmful consequences of stress can be induced in experimental atherosclerosis in rabbits / Laszlo Szekeres, Zoltan Szilvassy, Peter Ferdinandy, Istvan Nagy, Sarolta Karcsu, Sándor Csáti
Dátum:1997
ISSN:0022-2828
Megjegyzések:Multiple brief periods of rapid ventricular pacing confer bothshort- and long-term protection on the ischaemic heart. The duration of the short-term protection does notexceed 2 h, whereas the long-term protective effect appears several hours after the inducing insults, with maximalprotection 24?48 h later. Up to now, delayed cardiac protection by preceding ischaemic insults against harmfulconsequences of stress has been produced in the normal, healthy animal only. The purpose of this study was,therefore, to test whether delayed cardiac protection can be induced in experimental atherosclerosis in rabbitsproduced by feeding cholesterol-rich diet over 2 months. Repeated brief periods of rapid ventricular pacing wereused to induce delayed protection of the heart. Moderation of post-pacing right intracavitary ST segment elevationand that of the left ventricular end-diastolic pressure (both produced by ventricular overpacing: 500 beats/minfor 15 min) were found in normal animals as well as in those fed cholesterol-enriched diet. The short-livedprotection induced by a single 'preconditioning' pacing was reproducible only in normal animals. As measuredby means of radioimmunoassay, the protective effect of either short- or long-term protection appeared inparallel with an attenuation of ischaemia-induced increase in cardiac cyclic AMP content, in both normal andatherosclerotic rabbits. An increase in cardiac cyclic GMP content was characteristic of the short- but not longtermprotection. These results suggest that the delayed cardiac protection by preceding multiple brief rapidpacings operates even in experimental atherosclerosis, but the short-term protection induced by a singlepreconditioning stimulus is lost.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Atherosclerosis
ischaemia
Megjelenés:Journal of Molecular and Cellular Cardiology. - 29 :7 (1997), p. 1977-1983. -
További szerzők:Szilvássy Zoltán (1957-) (belgyógyász, farmakológus, klinikai farmakológus) Ferdinándy Péter Nagy István Karcsu Sarolta Csáti Sándor
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001-es BibID:BIBFORM037829
035-os BibID:PMID:8825877
Első szerző:Szilvássy Zoltán (belgyógyász, farmakológus, klinikai farmakológus)
Cím:The loss of pacing-induced preconditioning in atherosclerotic rabbits : role of hypercholesterolaemia / Zoltan Szilvassy, Peter Ferdinandy, Judith Szilvassy, Istvan Nagy, Sarolta Karcsu, Janos Lonovics, Laszlo Dux, Matyas Koltai
Dátum:1995
ISSN:0022-2828
Megjegyzések:A brief rapid pacing has been shown to protect rabbit heart against global myocardial ischaemia induced by subsequent longer pacing. We studied whether pacing-induced preconditioning was reproducible in experimental hypercholesterolaemia. In conscious rabbits with an implanted right ventricular electrode and left ventricular polyethylene catheters, pacing of 500 bpm over 20 min induced an intracavitary ST-segment elevation of 3.2 +/- 0.41 mV, shortened ventricular effective refractory period and increased left ventricular end-diastolic pressure from prepacing 105 +/- 3.9 ms and 4.0 +/- 0.93 mmHg to post-pacing 62 +/- 6.4 ms and 27.9 +/- 7.2 mmHg, respectively. A 10-min preconditioning pacing followed by a 5-min interval markedly attenuated these test pacing-induced ischaemic changes. Rabbits were fed a cholesterol-enriched diet over 4, 8 and 12 weeks, responded to a 5- or 10-min pacing with ischaemic changes of the same degree as did controls to a 10- or 20-min pacing, respectively. A 4-week diet elevated total serum cholesterol from 1.7 +/- 0.4 to 24.1 +/- 2.9 mmol/l without apparent atherosclerotic lesions in the thoracic aorta assessed by Oil-Red O staining and planimetry, but it abolished protection induced by a 5-min preconditioning pacing. A 12-week diet increased serum cholesterol and lesion surface area to 26.9 +/- 3.2 mmol/l and 89.6 +/- 6.4%, respectively, and continued to block preconditioning. When these animals were refed normal chow over additional 6 weeks, serum cholesterol level dropped to 2.6 +/- 0.80 mmol/l with no change in atherosclerotic lesions, the preconditioning effect, however, recovered. We conclude that hypercholesterolaemia blocks preconditioning irrespective of the development of atherosclerosis.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Ventricular overdrive pacing
Myocardial ischaemia
Preconditioning
Hypercholesterolaemia
Atherosclerosis
rabbit heart
egyetemen (Magyarországon) készült közlemény
Megjelenés:Journal of Molecular And Cellular Cardiology. - 27 : 12 (1995), p. 2559-2569. -
További szerzők:Ferdinándy Péter Szilvássy Judit (1960-2022) (fül- orr- gégész) Nagy István Karcsu Sarolta Lonovics János (Szeged) Dux László Koltai Mátyás
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