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001-es BibID:	BIBFORM046511
035-os BibID:	PMID:8595627
Első szerző:	Ferdinándy Péter
Cím:	KATP channel modulation in working rat hearts with coronary occlusion: effects of cromakalim, cicletanine, and glibenclamide / Péter Ferdinandy, Zoltán Szilvassy, Marie T. Droy-Lefaix, Thierry Tarrade, Matyas Koltai
Dátum:	1995
ISSN:	0008-6363
Megjegyzések:	OBJECTIVES: We studied the effects of ATP-sensitive potassium channel (KATP) modulation on ischemic cardiac performance and reperfusion-induced ventricular fibrillation (VF), and assessed the contribution of KATP to the cardioprotective and anti-arrhythmic effect of the anti-hypertensive drug cicletanine. METHODS: Isolated working rat hearts, subjected to a 10-min coronary occlusion followed by reperfusion, were perfused in the presence of vehicle, 0.1-60 microM cromakalim, an opener of KATP; 3-60 microM cicletanine; and 0.1-10 microM glibenclamide, a blocker of KATP, respectively. RESULTS: All concentrations of cicletanine, similarly to 0.1-10 microM cromakalim, attenuated ischemia-induced deterioration of aortic flow, left ventricular developed pressure, and left ventricular end-diastolic pressure. In contrast to cromakalim, cicletanine did not increase coronary flow. Cicletanine (60 microM) and cromakalim (10 and 60 microM) significantly reduced the incidence of reperfusion-induced VF; however, 60 microM cromakalim triggered VF during ischemia. Lower concentrations of cromakalim and cicletanine did not produce an anti-arrhythmic effect. Cardiac functional parameters were concentration dependently worsened by glibenclamide, and the drug did not change the incidence of VF. Glibenclamide (0.1 microM) did not significantly affect cardiac performance, but it did abolish the anti-ischemic effect of cromakalim (1-10 microM) and cicletanine (60 microM). Glibenclamide suppressed the anti-arrhythmic effect of 10 and 60 microM cromakalim; however, it did not affect the anti-arrhythmic effect of cicletanine. CONCLUSIONS: (i) The anti-ischemic but not the anti-arrhythmic effect of cicletanine may involve opening of KATP. (ii) opening of KATP attenuates, inhibition of the channel exacerbates functional consequences of coronary occlusion, and (iii) KATP opening attenuates reperfusion-induced VF, but it triggers ischemia-induced VF. KATP blocking does not affect VF.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban cicletanine myocardial ischemia myocardial function arrhythmias reperfusion potassium channel openers sulphonylureas
Megjelenés:	Cardiovascular Research. - 30 : 5 (1995), p. 781-787. -
További szerzők:	Szilvássy Zoltán (1957-) (belgyógyász, farmakológus, klinikai farmakológus) Droy-Lefaix, Marie-Thérèse Tarrade, Thierry Koltai Mátyás
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001-es BibID:	BIBFORM046575
035-os BibID:	PMID:1915586
Első szerző:	Szilvássy Zoltán (belgyógyász, farmakológus, klinikai farmakológus)
Cím:	Effect of cicletanine on overpacing-induced ST-segment elevation in conscious rabbits : a comparison with verapamil / Zoltán Szilvássy, Mátyás Koltai, László Szekeres, Thierry Tarrade, Pierre Braquet
Dátum:	1991
ISSN:	0014-2999
Megjegyzések:	We compared the effects of cicletanine (10 mg/kg i.v.) and verapamil (0.1 mg/kg i.v.) on heart rate, ventricular effective refractory period, systolic and diastolic arterial blood pressure and overpacing-induced ST-segment elevation detected by right ventricular intracavital electrogram in conscious rabbits. Cicletanine significantly reduced overpacing-induced ST-segment elevation, which is an indicator of myocardial ischemia and heart rate, but did not influence blood pressure and ventricular effective refractory period. Verapamil did not significantly influence ventricular effective refractory period, blood pressure or heart rate, but reduced the ST-segment elevation induced by frequency loading. These results suggest that acute treatment with cicletanine induces an anti-ischemic effect in the overpaced heart of conscious rabbits.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban Cicletanine Verapamil ST segment elevation Frequency loading Conscious rabbit
Megjelenés:	European Journal of Pharmacology. - 199 : 3 (1991), p. 383-386. -
További szerzők:	Koltai Mátyás Szekeres László Tarrade, Thierry Braquet, Pierre
Internet cím:	Szerző által megadott URL Intézményi repozitóriumban (DEA) tárolt változat
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