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001-es BibID:BIBFORM059122
035-os BibID:e0118089
Első szerző:Kiss Balázs
Cím:Analysis of the Effect of Locally Applied Inhomogeneous Static Magnetic Field-Exposure on Mouse Ear Edema : a Double Blind Study / Balázs Kiss, János F. László, Andrea Szalai, Róbert Pórszász
Dátum:2015
ISSN:1932-6203
Megjegyzések:The effect static magnetic field (SMF)-exposure may exert on edema development has been investigated. A 6 h long whole-body (WBSMF) or local (LSMF), continuous, inhomogeneous SMF-exposure was applied on anesthetized mice in an in vivo model of mustard oil (MO)-induced ear edema. LSMF was applied below the treated ear, below the lumbar spine, or below the mandible. Ear thickness (v) was checked 8 times during the exposure period (at 0, 0.25, 1, 2, 3, 4, 5, and 6 h). The effect size of the applied treatment (?) on ear thickness was calculated by the formula ? = 100% ? (1?vj/vi), where group i is the control group and j is the treated group. Results showed that MO treatment in itself induced a significant ear edema with an effect of 9% (p<0.001). WBSMF or LSMF on the spine in combination with MO treatment increased ear thickness even further resulting in an effect of ?>11% in both cases compared to SMF-exposure alone (p<0.001). In these cases SMF-exposure alone without MO treatment reduced ear thickness significantly (p<0.05), but within estimated experimental error. In cases of LSMF-exposure on the head, a significant SMF-exposure induced ear thickness reduction was found (? = 5%, p<0.05). LSMF-exposure on the spine affected ear thickness with and without MO treatment almost identically, which provides evidence that the place of local SMF action may be in the lower spinal region.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Edema
Magnets
Spine
Ears
Magnetic Fields
Histamine
Inflammation
Rodents
Megjelenés:Plos One. - 10 : 2 (2015), p. 1-14. -
További szerzők:László F. János (1956-) (fizikus) Szalai Andrea (1968-) (analitikus) Pórszász Róbert (1965-) (farmakológus, klinikai farmakológus)
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2.

001-es BibID:BIBFORM043721
Első szerző:László F. János (fizikus)
Cím:Exposure to static magnetic field delays induced preterm birth occurrence in mice / László János F., Pórszász Róbert
Dátum:2011
ISSN:0002-9378
Megjegyzések:The purpose of this study was to demonstrate that daily 40-minute whole body exposure to an inhomogeneous static magnetic field (SMF) prolongs induced preterm birth (PTB) in mice. STUDY DESIGN: The murine model for PTB induction was performed by the administration of 25 mikrog/animal lipopolysaccharide (LPS) intraperitoneally. The applied SMF was an inhomogeneous gradient field with 2.8-476.7 millitesla peak-to-peak magnetic induction range by 10 mm lateral periodicity. During SMF exposure, mice were free to move in their cage. RESULTS: The fetal development and the delivery were normal in animals that were exposed to SMF but not treated with LPS. SMF in these cases did not influence the term of delivery. In LPS-challenged animals, SMF exposure prolonged the time of PTB occurrence from 17.43 h (n = 7) to 21.93 h (n = 15) after the challenge (P < .05). CONCLUSION: Exposure to inhomogeneous SMF may have a valuable effect in the prevention of PTB and may have clinical relevance to humans.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:American Journal Of Obstetrics And Gynecology. - 205 : 4 (2011), p. e26-31. -
További szerzők:Pórszász Róbert (1965-) (farmakológus, klinikai farmakológus)
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3.

001-es BibID:BIBFORM020658
Első szerző:László F. János (fizikus)
Cím:Daily exposure to inhomogeneous static magnetic field significantly reduces blood glucose level in diabetic mice / János F. László, Judit Szilvási, Anett Fényi, Andrea Szalai, Klára Gyires, Róbert Pórszász
Dátum:2011
Megjegyzések:The present study was designed to reveal, whether the 30 min daily full body exposure of mice to aninhomogeneous static magnetic field (SMF) has a statistically significant effect on diabetic neuropathy.Materials and methods: Three different doses (100, 150, or 200 mg/kg) of streptozotocin (STZ) were administeredintraperitoneally in groups of mice to induce diabetes. Body weight, blood glucose level and the nociceptive temperaturethreshold of mice were monitored for a period of 12 weeks. The group treated with 200 mg/kg i.p. STZ produced manifestdiabetic neuropathy. Results were compared to non-treated (no SMF, no STZ) and SMF exposure without STZ-treatmentgroup (SMF, no STZ) group. The inhomogeneous SMF was in the range of 2.8?476.7 mT peak-to-peak magnetic flux density.Results: Whereas SMF exposure did not seem to affect body weight and nociceptive temperature threshold, it statisticallysignificantly (p50.001) reduced blood glucose level in the 200 mg/kg STZ (n?6) group.Conclusions: Daily SMF exposure repeated for several weeks is protective against the development of high blood glucoselevel in diabetic mice.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
neuropathy
diabetes
neuropathia diabetica
static magnetic field (SMF)
mouse
streptozotocin (STZ)
Megjelenés:International Journal of Radiation Biology. - 87 : 1 (2011), p. 36-45. -
További szerzők:Ujhelyi Judit Ágnes (1984-) (farmakológus) Fényi Anett Szalai Andrea (1968-) (analitikus) Gyires Klára Pórszász Róbert (1965-) (farmakológus, klinikai farmakológus)
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4.

001-es BibID:BIBFORM055517
Első szerző:Ujhelyi Judit Ágnes (farmakológus)
Cím:Analgesic and anti-inflammatory effectiveness of sitagliptin and vildagliptin in mice / Judit Újhelyi, Zoltán Újhelyi, Andrea Szalai, János F. László, Mayella Cayasso, Miklós Vecsernyés, Róbert Pórszász
Dátum:2014
ISSN:0167-0115
Megjegyzések:To validate the potential anti-inflammatory and analgesic role of sita- and vildagliptin, five different experimental 22modelswere used inmice: i)mustard oil-induced ear edema, ii) neutrophil accumulation, iii)mechanical and iv) 23thermal touch sensitivity in complete Freund's adjuvant-induced arthritis and v) capsaicin-induced plasma 24extravasation in the urinary bladder. For the complete examination period in i) the dose of 10 mg sitagliptin as 25well as 1?10 mg vildagliptin was found to significantly decrease ear edema as compared to positive control 26(p b 0.05, n = 8/group). All doses of sitagliptin provided an anti-inflammatory effect p b 0.005 (n = 10/ 27group) in test ii) and an analgesic effect in iii) except 3 mg. Vildagliptin was similarly effective in test ii) 28(p b 0.005, n = 10/group) as sitagliptin, but it failed to affect mechanical touch sensitivity. Unlike mechanical 29touch sensitivity, both gliptins could beneficially act on the thermal threshold (p b 0.05, n = 10/group). And 30only in tests v) could both gliptins reverse inflammation. Further studies are needed to support the suggestion 31that the utilization of these beneficial effects of gliptins may be considered in the treatment of Type 2 diabetic 32patients.
Tárgyszavak:Orvostudományok Gyógyszerészeti tudományok idegen nyelvű folyóiratközlemény külföldi lapban
Arthritis
Mechanical and thermal touch sensitivity
mice
Mustard oil
sitagliptin
vildagliptin
Megjelenés:Regulatory Peptides. - 194-195 (2014), p. 23-29. -
További szerzők:Ujhelyi Zoltán (1984-) (gyógyszerész) Szalai Andrea (1968-) (analitikus) László F. János (1956-) (fizikus) Cayasso, Mayella Vecsernyés Miklós (1959-) (gyógyszertechnológus, endokrinológus) Pórszász Róbert (1965-) (farmakológus, klinikai farmakológus)
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