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001-es BibID:	BIBFORM020658
Első szerző:	László F. János (fizikus)
Cím:	Daily exposure to inhomogeneous static magnetic field significantly reduces blood glucose level in diabetic mice / János F. László, Judit Szilvási, Anett Fényi, Andrea Szalai, Klára Gyires, Róbert Pórszász
Dátum:	2011
Megjegyzések:	The present study was designed to reveal, whether the 30 min daily full body exposure of mice to aninhomogeneous static magnetic field (SMF) has a statistically significant effect on diabetic neuropathy.Materials and methods: Three different doses (100, 150, or 200 mg/kg) of streptozotocin (STZ) were administeredintraperitoneally in groups of mice to induce diabetes. Body weight, blood glucose level and the nociceptive temperaturethreshold of mice were monitored for a period of 12 weeks. The group treated with 200 mg/kg i.p. STZ produced manifestdiabetic neuropathy. Results were compared to non-treated (no SMF, no STZ) and SMF exposure without STZ-treatmentgroup (SMF, no STZ) group. The inhomogeneous SMF was in the range of 2.8?476.7 mT peak-to-peak magnetic flux density.Results: Whereas SMF exposure did not seem to affect body weight and nociceptive temperature threshold, it statisticallysignificantly (p50.001) reduced blood glucose level in the 200 mg/kg STZ (n?6) group.Conclusions: Daily SMF exposure repeated for several weeks is protective against the development of high blood glucoselevel in diabetic mice.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban neuropathy diabetes neuropathia diabetica static magnetic field (SMF) mouse streptozotocin (STZ)
Megjelenés:	International Journal of Radiation Biology. - 87 : 1 (2011), p. 36-45. -
További szerzők:	Ujhelyi Judit Ágnes (1984-) (farmakológus) Fényi Anett Szalai Andrea (1968-) (analitikus) Gyires Klára Pórszász Róbert (1965-) (farmakológus, klinikai farmakológus)
Internet cím:	DOI Intézményi repozitóriumban (DEA) tárolt változat
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001-es BibID:	BIBFORM055517
Első szerző:	Ujhelyi Judit Ágnes (farmakológus)
Cím:	Analgesic and anti-inflammatory effectiveness of sitagliptin and vildagliptin in mice / Judit Újhelyi, Zoltán Újhelyi, Andrea Szalai, János F. László, Mayella Cayasso, Miklós Vecsernyés, Róbert Pórszász
Dátum:	2014
ISSN:	0167-0115
Megjegyzések:	To validate the potential anti-inflammatory and analgesic role of sita- and vildagliptin, five different experimental 22modelswere used inmice: i)mustard oil-induced ear edema, ii) neutrophil accumulation, iii)mechanical and iv) 23thermal touch sensitivity in complete Freund's adjuvant-induced arthritis and v) capsaicin-induced plasma 24extravasation in the urinary bladder. For the complete examination period in i) the dose of 10 mg sitagliptin as 25well as 1?10 mg vildagliptin was found to significantly decrease ear edema as compared to positive control 26(p b 0.05, n = 8/group). All doses of sitagliptin provided an anti-inflammatory effect p b 0.005 (n = 10/ 27group) in test ii) and an analgesic effect in iii) except 3 mg. Vildagliptin was similarly effective in test ii) 28(p b 0.005, n = 10/group) as sitagliptin, but it failed to affect mechanical touch sensitivity. Unlike mechanical 29touch sensitivity, both gliptins could beneficially act on the thermal threshold (p b 0.05, n = 10/group). And 30only in tests v) could both gliptins reverse inflammation. Further studies are needed to support the suggestion 31that the utilization of these beneficial effects of gliptins may be considered in the treatment of Type 2 diabetic 32patients.
Tárgyszavak:	Orvostudományok Gyógyszerészeti tudományok idegen nyelvű folyóiratközlemény külföldi lapban Arthritis Mechanical and thermal touch sensitivity mice Mustard oil sitagliptin vildagliptin
Megjelenés:	Regulatory Peptides. - 194-195 (2014), p. 23-29. -
További szerzők:	Ujhelyi Zoltán (1984-) (gyógyszerész) Szalai Andrea (1968-) (analitikus) László F. János (1956-) (fizikus) Cayasso, Mayella Vecsernyés Miklós (1959-) (gyógyszertechnológus, endokrinológus) Pórszász Róbert (1965-) (farmakológus, klinikai farmakológus)
Internet cím:	Szerző által megadott URL DOI Intézményi repozitóriumban (DEA) tárolt változat
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