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001-es BibID:BIBFORM055695
Első szerző:Nagy D.
Cím:Stable gene silencing of TASK-3 channels in melanoma cells induce intrinsic apoptosis / D. Nagy, M. Gönczi, Zs. Nagy, A. Tóth, B. Dienes, J. Fodor, G. Szücs, Z. Rusznák, Á. Szöőr, L. Csernoch
Dátum:2014
ISSN:1748-1708
Tárgyszavak:Orvostudományok Elméleti orvostudományok idézhető absztrakt
Megjelenés:Acta Physiologica 211 : Suppl. (2014), p. 40. -
További szerzők:Gönczi Mónika (1974-) (élettanász) Nagy Zs. Tóth A. Dienes Beatrix (1972-) (élettanász, molekuláris biológus) Fodor János (1973-) (élettanász, biotechnológus) Szűcs Géza (1948-) (élettanász) Rusznák Zoltán (1965-) (élettanász) Szöőr Árpád (1984-) (orvos) Csernoch László (1961-) (élettanász)
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2.

001-es BibID:BIBFORM018463
Első szerző:Pál Balázs (élettanász)
Cím:Depolarization-activated K+ currents of the bushy neurones of the rat cochlear nucleus in a thin brain slice preparation / Pál B., Rusznák Z., Harasztosi C., Szücs G.
Dátum:2004
Megjegyzések:Depolarization-activated outward currents of bushy neurones of 6-14-day-old Wistar rats have been investigated in a brain slice preparation. Under current-clamp, the cells produced a single action potential at the beginning of suprathreshold depolarizing current steps. On voltage-clamp depolarizations, the cells produced a mixed outward K+ current that included a component with rapid activation and rapid inactivation, little TEA+ sensitivity, a half-inactivation voltage of -77 +/- 2 mV (T = 25 degrees C; n = 7; Mean +/- S.E.M.) and single-exponential recovery from inactivation (taurecovery= 12 +/- 1 ms at -100 mV; n=3). This transient component was identified as an A-type K+ current. Bushy cells developed a high-threshold TEA-sensitive K+ current that exhibited less prominent inactivation. These characteristics suggested that this current was associated with the activation of delayed rectifier K+ channels. Bushy neurones also possessed a low-threshold outward K+ current that showed partial inactivation and high 4-aminopyridine sensitivity. Part of this current component was blocked by 200 nmol/l dendrotoxin-I. Application of 100 micromol/l 4-aminopyridine changed the firing behaviour of the bushy neurones from the primary-like pattern to a much less rapidly adapting one, suggesting that the low-threshold current might have important roles in maintaining the physiological function of the cells.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény hazai lapban
cochlear nucleus
bushy cell
outward K+ currents
dendrotoxin-I
4-aminopyridine
Megjelenés:Acta Physiologica Hungarica. - 91 : 2 (2004), p. 83-98. -
További szerzők:Rusznák Zoltán (1965-) (élettanász) Harasztosi Csaba Szűcs Géza (1948-) (élettanász)
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3.

001-es BibID:BIBFORM050571
035-os BibID:PMID:6316729
Első szerző:Szűcs Géza (élettanász)
Cím:Effects of physostigmine on the excitation-contraction coupling of skeletal muscle fibres / G. Szűcs, Margit Fuxreiter, Éva Sirkó, Á. Szállási
Dátum:1983
ISSN:0231-424X 1588-2683
Megjegyzések:The effects of physostigmine on the electrophysiological properties of the surface membrane and on the different steps of excitation-contraction coupling were studied on the skeletal muscle of the frog (Rana esculenta). On analysing the phase plane trajectories of electrically evoked action potentials it was found that, similarly to the previously described pH dependence of the depolarizing effect of the alkaloid [14], the physostigmine-induced inhibition of the voltage-dependent sodium and potassium conductances responsible for the generation of the spike was increased in correlation with the decrease of external hydrogen ion concentration (pH 6.4, 7.0 and 8.4). When performing examinations on cut muscle fibres using the single vaseline gap voltage clamp technique [9], physostigmine did not exert any characteristic effect on the strength-duration curve of the contraction threshold determined by short depolarizing pulses even at higher concentrations (2 and 10 mmol/l; pH 7.0). In some cases the value of the rheobase was shifted to a variable extent towards more negative membrane potentials. On using the metallochromic indicator dye antipyrylazo III it was found that the application of 2 mmol/l physostigmine (pH 7.0) decreased the amount of calcium released during the depolarizing pulses. To reach the contraction threshold, a smaller increase in calcium concentration was necessary in the presence of the alkaloid. The relaxing phase of contractions elicited by depolarizing pulses was slowed down due to 2 mmol/l (pH 7.0) physostigmine treatment although the rate of the falling phase of the calcium transients increased simultaneously. The decrease in external hydrogen ion concentration facilitated the development of modifications in the shape of the contractions. The conclusion was drawn that the effects of physostigmine exhibit pH dependence. The alkaloid decreases calcium release from the sarcoplasmic reticulum and increases the calcium sensitivity of the contractile proteins.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
skeletal muscle
intracellular calcium transients
physiostigmine
pH dependence
Megjelenés:Acta Physiologica Hungarica. - 62 : 1 (1983), p. 61-73. -
További szerzők:Fuxreiter Margit Sirkó Éva Szállási Árpád (1960-) (pathológus)
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