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001-es BibID:	BIBFORM037816
Első szerző:	Kőszeghy Áron (Ph.D hallgató, élettanász)
Cím:	Activation of muscarinic receptors increases the activity of the granule neurones of the rat dorsal cochlear nucleus : a calcium imaging study / Áron Kőszeghy, János Vincze, Zoltán Rusznák, Yuhong Fu, George Paxinos, László Csernoch, Géza Szücs
Dátum:	2012
ISSN:	0031-6768
Megjegyzések:	Acetylcholine modulates the function of the cochlear nucleus via several pathways. In this study the effects of cholinergic stimulation were studied on the cytoplasmic Ca2+ concentration of granule neurones of the rat dorsal cochlear nucleus (DCN). Ca2+ transients were recorded in Oregon-Green-BAPTA 1-loaded brain slices using a calcium imaging technique. For the detection, identification, and characterisation of the Ca2+ transients, a wavelet analysis-based method was developed. Granule cells were identified on the basis of their size and localisation. The action potential-coupled character of the Ca2+ transients of the granule cells was established by recording fluorescence changes and electrical activity simultaneously. Application of the cholinergic agonist carbamyl-choline (CCh) significantly increased the frequency of the Ca2+ transients (from 0.37 to 6.31 min-1, corresponding to a 17.1-fold increase; n = 89). This effect was antagonised by atropine, whereas CCh could still evoke an 8.3-fold increase of the frequency of the Ca2+ transients when hexamethonium was present. Using immunolabelling, the expression of both type 1 and type 3 muscarinic receptors (M1 and M3 receptors, respectively) was demonstrated in the granule cells. Application of 1,1-dimethyl-4-diphenylacetoxypiperidinium iodide (an M3-specific antagonist) prevented the onset of the CCh effect, whereas an M1-specific antagonist (pirenzepine) was less effective. We conclude that cholinergic stimulation increases the activity of granule cells, mainly by acting on their M3 receptors. The modulation of the firing activity of the granule cells, in turn, may modify the firing of projection neurones, and may adjust signal processing in the entire DCN.
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	Pflügers Archiv. - 463 : 6 (2012), p. 829-844. -
További szerzők:	Vincze János (1988-) (orvos) Rusznák Zoltán (1965-) (élettanász) Fu, YuHong Paxinos, George Csernoch László (1961-) (élettanász) Szűcs Géza (1948-) (élettanász)
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001-es BibID:	BIBFORM009114
Első szerző:	Rusznák Zoltán (élettanász)
Cím:	Spiral ganglion neurones : an overview of morphology, firing behaviour, ionic channels and function / Zoltán Rusznák, Géza Szűcs
Dátum:	2009
ISSN:	0031-6768
Megjegyzések:	The spiral ganglion cells provide the afferent innervation of the hair cells of the organ of Corti. Ninety-five percent of these cells (termed type I spiral ganglion neurones) are in synaptic contact with the inner hair cells, whereas about 5% of them are type II cells, which are responsible for the sensory innervation of the outer hair cells. To understand the function of the spiral ganglion neurones, it is important to explore their membrane properties, understand their activity patterns and describe the variety of ionic channels determining their behaviour. In this review, a brief description is given of the various experimental methods that allow the investigation of the spiral ganglion cells, followed by the discussion of their action potential firing patterns and ionic conductances. The presence, distribution and significance of the K(+) currents of the spiral ganglion cells are specifically addressed, along with the introduction of the putative subunit compositions of the relevant voltage-gated K(+) channels
Tárgyszavak:	Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban action potentials Aging anatomy and histology Animals behaviour Brain-Derived Neurotrophic Factor calcium calcium channel Cells,Cultured channel cytology drug effects Elapid Venoms Hair Cells Health Histological Techniques Humans innervation metabolism method morphology mouse nerve Nerve Growth Factors neurone Neurons Organ of Corti pharmacology physiology Potassium potassium channel review Sodium sodium channel Spiral Ganglion
Megjelenés:	Pflügers Archiv. - 457 : 6 (2009), p. 1303-1325. -
További szerzők:	Szűcs Géza (1948-) (élettanász)
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