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1.
001-es BibID:
BIBFORM005093
Első szerző:
Panyi György (biofizikus)
Cím:
K+ channel blockers : novel tools to inhibit T cell activation leading to specific immunosuppression / Panyi, G., Possani, L. D., Rodriguez de la Vega R. C., Gaspar, R., Varga, Z.
Dátum:
2006
ISSN:
381-6128 (Print)
Megjegyzések:
During the last two decades since the identification and characterization of T cell potassium channels great advances have been made in the understanding of the role of these channels in T cell functions, especially in antigen-induced activation. Their limited tissue distribution and the recent discovery that different T cell subtypes carrying out distinct immune functions show specific expression levels of these channels have made T cell potassium channels attractive targets for immunomodulatory drugs. Many toxins of various animal species and a structurally diverse array of small molecules inhibiting these channels with varying affinity and selectivity were found and their successful use in immunosuppression in vivo was also demonstrated. Better understanding of the topological differences between potassium channel pores, detailed knowledge of toxin and small-molecule structures and the identification of the binding sites of blocking compounds make it possible to improve the selectivity and affinity of the lead compounds by introducing modifications based on structural information. In this review the basic properties and physiological roles of the voltage-gated Kv1.3 and the Ca2+-activated IKCa1 potassium channels are discussed along with an overview of compounds inhibiting these channels and approaches aiming at producing more efficient modulators of immune functions for the treatment of diseases like sclerosis multiplex and type I diabetes.
Tárgyszavak:
Orvostudományok
Elméleti orvostudományok
idegen nyelvű folyóiratközlemény külföldi lapban
Amino Acid Sequence
Animal
Animals
Binding Sites
Biophysics
chemistry
Cnidarian Venoms
Drug Design
drug effects
Humans
Hungary
immunology
Immunosuppression
Immunosuppressive Agents
Intermediate-Conductance Calcium-Activated Potassium Channels
Ion Channel Gating
Kv1.3 Potassium Channel
Lymphocyte Activation
metabolism
Models, Molecular
Molecular Sequence Data
Molecular Structure
pharmacology
Potassium
Potassium Channel Blockers
Potassium Channels
Protein Conformation
Pyrazoles
Quinolines
Research
Structure-Activity Relationship
Support
T-Lymphocytes
Toxins
Megjelenés:
Current Pharmaceutical Design. - 12 : 18 (2006), p. 2199-2220. -
További szerzők:
Possani, Lourival Domingos
Rodriguez de la Vega, Ricardo C.
Gáspár Rezső (1944-) (biofizikus)
Varga Zoltán (1969-) (biofizikus, szakfordító)
Borító:
Saját polcon:
2.
001-es BibID:
BIBFORM002770
Első szerző:
Varga Zoltán (biofizikus, szakfordító)
Cím:
Involvement of membrane channels in autoimmune disorders / Zoltán Varga, Péter Hajdu, György Panyi, Rezső Gáspár, Zoltán Krasznai
Dátum:
2007
Megjegyzések:
Ion channels are ubiquitous transmembrane proteins that are involved in a wide variety of cellular functions by selectively controlling the passage of ions across the plasma membrane. Among these functions many immune processes, including those in autoimmune reactions, also rely on the operation of ion channels, but the roles of ion channels can be very diverse. Here the participation of ion channels in three different roles in autoimmune processes is discussed: 1. ion channels in effector immune cells attacking other tissues causing autoimmune diseases, such as multiple sclerosis; 2. ion channels as direct targets of the immune system whereby loss of channel function leads to disease, as in myasthenia gravis; 3. ion channels whose function is modulated in the target cells by an apoptotic signal transduction cascade, such as the Fas/Fas ligand pathway. The numerous tasks that ion channels perform in autoimmune disorders and the wealth of information that has been gathered about them in recent years together provide a good basis for the design and production of drugs that may be effectively used in the therapy of these diseases
Tárgyszavak:
Természettudományok
Biológiai tudományok
idegen nyelvű folyóiratközlemény külföldi lapban
Animals
Autoimmune Diseases
Biophysics
Cell Membrane
Cells
Humans
Hungary
Immune System
Ion Channels
Lymphocyte Activation
metabolism
physiology
Proteins
Research
Signal Transduction
Support
T-Lymphocytes
therapy
Megjelenés:
Current Pharmaceutical Design. - 13 : 24 (2007), p. 2456-2468. -
További szerzők:
Hajdu Péter (1975-) (biofizikus)
Panyi György (1966-) (biofizikus)
Gáspár Rezső (1944-) (biofizikus)
Krasznai Zoltán (1950-) (biofizikus)
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elektronikus változat
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