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001-es BibID:BIBFORM051954
Első szerző:Panyi György (biofizikus)
Cím:Ion channels and anti-cancer immunity / Gyorgy Panyi, Christine Beeton, Antonio Felipe
Dátum:2014
Megjegyzések:The outcome of a malignant disease depends on the efficacy of the immune system to destroy cancer cells. Key steps in this process, for example the generation of a proper Ca(2+) signal induced by recognition of a specific antigen, are regulated by various ion channel including voltage-gated Kv1.3 and Ca(2+)-activated KCa3.1 K(+) channels, and the interplay between Orai and STIM to produce the Ca(2+)-release-activated Ca(2+) (CRAC) current required for T-cell proliferation and function. Understanding the immune cell subset-specific expression of ion channels along with their particular function in a given cell type, and the role of cancer tissue-dependent factors in the regulation of operation of these ion channels are emerging questions to be addressed in the fight against cancer disease. Answering these questions might lead to a better understanding of the immunosuppression phenomenon in cancer tissue and the development of drugs aimed at skewing the distribution of immune cell types towards killing of the tumour cells
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
article
Biophysics
cell biology
Cells
EXPRESSION
Hungary
Immune System
Immunosuppression
Ion Channels
Research
Research Support
Support
Megjelenés:Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. - 369 : 1638 (2014), p. 20130106. -
További szerzők:Beeton, Christine Felipe, Antonio
Internet cím:DOI
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2.

001-es BibID:BIBFORM100132
035-os BibID:(WOS)000675288400019 (Scopus)85110575908 (Cikkazonosító)14632
Első szerző:Vallejo-Gracia, Albert
Cím:KCNE4-dependent functional consequences of Kv1.3-related leukocyte physiology / Vallejo-Gracia Albert, Sastre Daniel, Colomer-Molera Magalí, Solé Laura, Navarro-Pérez María, Capera Jesusa, Roig Sara R., Pedrós-Gámez Oriol, Estadella Irene, Szilágyi Orsolya, Panyi Gyorgy, Hajdú Péter, Felipe Antonio
Dátum:2021
ISSN:2045-2322
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:Scientific Reports. - 11 : 1 (2021), p. 14632. -
További szerzők:Sastre, Daniel Colomer-Molera, Magalí Solé, Laura Navarro-Pérez, María Capera, Jesusa Roig, Sara R. Pedrós-Gámez, Oriol Estadella, Irene Szilágyi Orsolya (1985-) (molekuláris biológus, biokémikus) Panyi György (1966-) (biofizikus) Hajdu Péter (1975-) (biofizikus) Felipe, Antonio
Pályázati támogatás:K128525
OTKA
K119417
OTKA
GINOP-2.3.2-15-2016-00044
GINOP
EFOP-3.6.1-16-2016-00022
EFOP
Internet cím:Szerző által megadott URL
DOI
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3.

001-es BibID:BIBFORM010313
Első szerző:Zsíros Emese (orvos)
Cím:Developmental switch of the expression of ion channels in human dendritic cells / Zsiros Emese, Kis-Tóth Katalin, Hajdú Péter, Gáspár Rezső, Joanna Bielansk, Antonio Felipe, Rajnavölgyi Éva, Panyi György
Dátum:2009
ISSN:0022-1767
Megjegyzések:Modulation of the expression and activity of plasma membrane ion channels is one of the mechanisms by which immune cells can regulate their intracellular Ca2(+) signaling pathways required for proliferation and/or differentiation. Voltage-gated K+ channels, inwardly rectifying K+ channels, and Ca2+-activated K+ channels have been described to play a major role in controlling the membrane potential in lymphocytes and professional APCs, such as monocytes, macrophages, and dendritic cells (DCs). Our study aimed at the characterization and identification of ion channels expressed in the course of human DC differentiation from monocytes. We report in this study for the first time that immature monocyte-derived DCs express voltage-gated Na+ channels in their plasma membrane. The analysis of the biophysical and pharmacological properties of the current and PCR-based cloning revealed the presence of Nav1.7 channels in immature DCs. Transition from the immature to a mature differentiation state, however, was accompanied by the down-regulation of Nav1.7 expression concomitant with the up-regulation of voltage-gated Kv1.3 K+ channel expression. The presence of Kv1.3 channels seems to be common for immune cells; hence, selective Kv1.3 blockers may emerge as candidates for inhibiting various functions of mature DCs that involve their migratory, cytokine-secreting, and T cell-activating potential.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Union of Pharmacology
Dependent K+ channel
Human Lymhocytes T
Potassium channels
Sodium Channels
Electrophysiological properties
Peripheral nerve
Immune system
Macrophages
Activation
Megjelenés:The Journal of Immunology 183 : 7 (2009), p. 4483-4492. -
További szerzők:Kis-Tóth Katalin (1975-) (immunológus) Hajdu Péter (1975-) (biofizikus) Gáspár Rezső (1944-) (biofizikus) Bielansk, Joanna Felipe, Antonio Rajnavölgyi Éva (1950-) (immunológus) Panyi György (1966-) (biofizikus)
Internet cím:Szerző által megadott URL
DOI
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