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001-es BibID:BIBFORM065612
Első szerző:Ganti, Ketaki
Cím:The Human Papillomavirus E6 PDZ Binding Motif: From Life Cycle to Malignancy / Ketaki Ganti, Justyna Broniarczyk, Wiem Manoubi, Paola Massimi, Suruchi Mittal, David Pim, Anita Szalmas, Jayashree Thatte, Miranda Thomas, Vjekoslav Tomaić, Lawrence Banks
Dátum:2015
ISSN:1999-4915
Megjegyzések:Cancer-causing HPV E6 oncoproteins are characterized by the presence of a PDZ binding motif (PBM) at their extreme carboxy terminus. It was long thought that this region of E6 had a sole function to confer interaction with a defined set of cellular substrates. However, more recent studies have shown that the E6 PBM has a complex pattern of regulation, whereby phosphorylation within the PBM can regulate interaction with two classes of cellular proteins: those containing PDZ domains and the members of the 14-3-3 family of proteins. In this review, we explore the roles that the PBM and its ligands play in the virus life cycle, and subsequently how these can inadvertently contribute towards the development of malignancy. We also explore how subtle alterations in cellular signal transduction pathways might result in aberrant E6 phosphorylation, which in turn might contribute towards disease progression.
Tárgyszavak:Természettudományok Biológiai tudományok idegen nyelvű folyóiratközlemény külföldi lapban
HPV
E6
PDZ
14-3-3
cell polarity
Megjelenés:Viruses. - 7 : 7 (2015), p. 3530-3551. -
További szerzők:Broniarczyk, Justyna Manoubi, Wiem Massimi, Paola Mittal, Suruchi Pim, David Szalmás Anita (1978-) (biológus, mikrobiológus, klinikai mikrobiológus) Thatte, Jayashree Thomas, Miranda Tomaić, Vjekoslav Banks, Lawrence
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