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001-es BibID:	BIBFORM070600
Első szerző:	Ebrahimi, Fatemeh
Cím:	Comparison of rates of fecal colonization with extended-spectrum beta-lactamase-producing enterobacteria among patients in different wards, outpatients and medical students / Ebrahimi Fatemeh, Mózes Julianna, Monostori Júlia, Gorácz Orsolya, Fésűs Adina, Majoros László, Szarka Krisztina, Kardos Gábor
Dátum:	2016
ISSN:	0385-5600
Tárgyszavak:	Orvostudományok Gyógyszerészeti tudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	Microbiology And Immunology. - 60 : 5 (2016), p. 285-294. -
További szerzők:	Mózes Julianna (1982-) (orvosdiagnosztikai laboratóriumi analitikus, okleveles népegészségügyi szakember) Monostori Júlia Kungler-Gorácz Orsolya (1985-) (gyógyszerész) Fésüs Adina (1978-) (gyógyszerész) Majoros László (1966-) (szakorvos, klinikai mikrobiológus) Szarka Krisztina (1971-) (molekuláris biológus, mikrobiológus) Kardos Gábor (1974-) (szakorvos, klinikai mikrobiológus)
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001-es BibID:	BIBFORM047703
035-os BibID:	PMID:23649705
Első szerző:	Gáll Tamás (molekuláris biológus, mikrobiológus)
Cím:	Genomic differences in the background of different severity in juvenile-onset respiratory papillomatoses associated with human papillomavirus type 11 / Tamás Gáll, Andrea Kis, Tímea Zsófia Tatár, Gábor Kardos, Lajos Gergely, Krisztina Szarka
Dátum:	2013
ISSN:	0300-8584
Megjegyzések:	This study aimed to compare complete genome sequences of human papillomavirus (HPV) type 11 from two solitary papillomas (considered minimally aggressive), two moderately (six and nine episodes) and two highly aggressive (30 and 33 episodes) juvenile-onset respiratory papillomatoses. Genomic regions were sequenced using the Sanger method; sequences were compared to available GenBank genomes. Activity of the long control region (LCR) was assessed in HEp-2 cell line using luciferase assays and compared to that of the reference (GenBank Accession Number M14119). Site-directed mutagenesis was performed to confirm the association of polymorphisms with differences in LCR activity. Eleven alterations resulted in amino acid changes in different open reading frames. A72E in E1 and Q86K in E2 proteins were exclusively present in a moderately aggressive disease, L1 alterations A476V and S486F were unique to a severe papillomatosis. HPV11s in both solitary papillomas had identical LCRs containing a T7546C polymorphism, which strongly attenuated LCR activity, as confirmed by site-directed mutagenesis. This strong attenuator polymorphism was also present in the other four genomes showing significantly higher activities, but in these other alterations with demonstrable but statistically not significant attenuating (A7413C, 7509 T deletion) or enhancing (C7479T, T7904A) effect on transactivating potential (as demonstrated by site-directed mutagenesis) were also detected. LCR activities corresponded well to severity, excepting the highly aggressive papillomatosis with the L1 alterations. Presence of intratypic variants cannot explain differences in severity of respiratory papillomatoses associated with HPV11; virulence seems to be determined by the interaction of multiple genetic differences.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	Medical Microbiology and Immunology. - 202 : 5 (2013), p. 353-363. -
További szerzők:	Kis Andrea (1981-) (molekuláris biológus, mikrobiológus) Tatár Tímea Zsófia Kardos Gábor (1974-) (szakorvos, klinikai mikrobiológus) Gergely Lajos (1940-) (szakorvos, klinikai mikrobiológus) Szarka Krisztina (1971-) (molekuláris biológus, mikrobiológus)
Pályázati támogatás:	OTKA 73145 OTKA
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001-es BibID:	BIBFORM008946
Első szerző:	Szarka Krisztina (molekuláris biológus, mikrobiológus)
Cím:	Progressive increase of human papillomavirus carriage rates in potentially malignant and malignant oral disorders with increasing malignant potential / Szarka Krisztina, Tar Ildikó, Fehér Enikő, Gáll Tamás, Kis Andrea, D. Tóth Etelka, Boda Róbert, Márton Ildikó, Gergely Lajos
Dátum:	2009
Megjegyzések:	We investigated the potential role of human papillomaviruses (HPVs) in potentially malignant oral disorders, oral leukoplakia (OL) and oral lichen planus (OLP), and in oral squamous cell cancer (OSCC) in an Eastern Hungarian population with a high incidence of OSCC. Methods: Excised tumor samples (65 OSCC patients) and exfoliated cells from potentially malignant lesions (from 44 and 119 patients with OL and OLP, respectively) as well as from healthy controls (72 individuals) were analysed. OLPs were classified based on clinical appearance, 61 patients had erosive?atrophic lesions (associated with higher malignancy risk, EA-OLP) and 58 had non-erosive non-atrophic lesions (with lower risk of becoming malignant, non-EA-OLP), respectively. Exfoliated cells collected from apparently healthy mucosa accompanied each lesion sample. HPV was detected by MY/GP polymerase chain reaction (PCR) and genotyped by restriction analysis of amplimers. Copy numbers in lesions were determined using real-time PCR. Prevalence rates, copy number distributions, and association with risk factors and diseases were analysed using chi-square test, t-test, and logistic regression, respectively. Results: We detected HPVs significantly more frequently in lesions than in controls (P ? 0.001 in all comparisons). HPV prevalence increased gradually with increasing severity of lesions (32.8, 40.9, and 47.7% in OLP, OL, and OSCC, respectively). Copy number distribution patterns roughly corresponded to prevalence rates, but OLP and OL were comparable. HPV prevalence differed significantly between EA-OLP and non-EA-OLP groups (42.6 vs. 22.4%); EA-OLP group showed a prevalence similar to that found in OL. Conclusion: HPVs may be involved in the development or progression of not only OSCC but also of potentially malignant oral lesions.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban human papillomavirus oral carcinogenesis
Megjelenés:	Oral Microbiology and Immunology 24 : 4 (2009), p. 314-318. -
További szerzők:	Tar Ildikó (1967-) (fogszakorvos) Fehér Enikő (1981-) (molekuláris biológus, mikrobiológus) Gáll Tamás (1982-) (molekuláris biológus, mikrobiológus) Kis Andrea (1981-) (molekuláris biológus, mikrobiológus) D. Tóth Etelka (1975-) (fogszakorvos) Boda Róbert (1978-) (fogszakorvos) Márton Ildikó (1954-) (fogszakorvos) Gergely Lajos (1940-) (szakorvos, klinikai mikrobiológus)
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