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001-es BibID:	BIBFORM008946
Első szerző:	Szarka Krisztina (molekuláris biológus, mikrobiológus)
Cím:	Progressive increase of human papillomavirus carriage rates in potentially malignant and malignant oral disorders with increasing malignant potential / Szarka Krisztina, Tar Ildikó, Fehér Enikő, Gáll Tamás, Kis Andrea, D. Tóth Etelka, Boda Róbert, Márton Ildikó, Gergely Lajos
Dátum:	2009
Megjegyzések:	We investigated the potential role of human papillomaviruses (HPVs) in potentially malignant oral disorders, oral leukoplakia (OL) and oral lichen planus (OLP), and in oral squamous cell cancer (OSCC) in an Eastern Hungarian population with a high incidence of OSCC. Methods: Excised tumor samples (65 OSCC patients) and exfoliated cells from potentially malignant lesions (from 44 and 119 patients with OL and OLP, respectively) as well as from healthy controls (72 individuals) were analysed. OLPs were classified based on clinical appearance, 61 patients had erosive?atrophic lesions (associated with higher malignancy risk, EA-OLP) and 58 had non-erosive non-atrophic lesions (with lower risk of becoming malignant, non-EA-OLP), respectively. Exfoliated cells collected from apparently healthy mucosa accompanied each lesion sample. HPV was detected by MY/GP polymerase chain reaction (PCR) and genotyped by restriction analysis of amplimers. Copy numbers in lesions were determined using real-time PCR. Prevalence rates, copy number distributions, and association with risk factors and diseases were analysed using chi-square test, t-test, and logistic regression, respectively. Results: We detected HPVs significantly more frequently in lesions than in controls (P ? 0.001 in all comparisons). HPV prevalence increased gradually with increasing severity of lesions (32.8, 40.9, and 47.7% in OLP, OL, and OSCC, respectively). Copy number distribution patterns roughly corresponded to prevalence rates, but OLP and OL were comparable. HPV prevalence differed significantly between EA-OLP and non-EA-OLP groups (42.6 vs. 22.4%); EA-OLP group showed a prevalence similar to that found in OL. Conclusion: HPVs may be involved in the development or progression of not only OSCC but also of potentially malignant oral lesions.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban human papillomavirus oral carcinogenesis
Megjelenés:	Oral Microbiology and Immunology 24 : 4 (2009), p. 314-318. -
További szerzők:	Tar Ildikó (1967-) (fogszakorvos) Fehér Enikő (1981-) (molekuláris biológus, mikrobiológus) Gáll Tamás (1982-) (molekuláris biológus, mikrobiológus) Kis Andrea (1981-) (molekuláris biológus, mikrobiológus) D. Tóth Etelka (1975-) (fogszakorvos) Boda Róbert (1978-) (fogszakorvos) Márton Ildikó (1954-) (fogszakorvos) Gergely Lajos (1940-) (szakorvos, klinikai mikrobiológus)
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001-es BibID:	BIBFORM040793
Első szerző:	Szládek Györgyi
Cím:	High co-prevalence of genogroup 1 TT virus and human papillomavirus is associated with poor clinical outcome of laryngeal carcinoma / Szladek G., Juhasz A., Kardos G., Szoke K., Major T., Sziklai I., Tar I., Marton I., Konya J., Gergely L., Szarka K.
Dátum:	2005
ISSN:	0021-9746
Megjegyzések:	BACKGROUND: The aetiology and factors leading to the progression of laryngeal cancer are still unclear. Although human papillomavirus (HPV) has been suggested to play a role, reports concerning the effect of HPV infection on tumour development are controversial. Recently, transfusion transmitted virus (TTV) was suggested to play a role in certain infections as a causative or coinfecting agent. AIMS: To investigate whether the development and progression of laryngeal squamous cell carcinoma is associated with coinfection with TTV and HPV. METHODS: The prevalence of TTV and HPV was investigated using the polymerase chain reaction in tissue samples from 40 healthy individuals, 10 patients with recurrent papillomatosis, five patients with papillomatosis with malignant transformation, and 25 patients with laryngeal carcinoma. The obtained prevalence data were compared and analysed statistically. RESULTS: In the 11 patients with carcinoma who had metastasis or relapse there was a high rate of coinfection with genogroup 1 TTV and HPV (eight of 11), whereas in the 14 without tumour progression no coinfection was found. Coinfection was associated with significantly lower tumour free survival in patients with carcinoma (p < 0.001). Furthermore, four of five patients who had papillomatosis with malignant transformation were coinfected with genogroup 1 TTV and HPV. CONCLUSIONS: Although the nature of cooperation between HPV and TTV needs to be investigated further, coinfection with genogroup 1 TTV and HPV appears to be associated with poor clinical outcome in laryngeal cancer.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	Journal Of Clinical Pathology. - 58 : 4 (2005), p. 402-405. -
További szerzők:	Juhász Attila (1970-) (szakorvos, klinikai mikrobiológus) Kardos Gábor (1974-) (szakorvos, klinikai mikrobiológus) Szőke Krisztina Major Tamás (1973-) (fül-orr-gégész) Sziklai István (1954-) (fül-orr-gégész) Tar Ildikó (1967-) (fogszakorvos) Márton Ildikó (1954-) (fogszakorvos) Kónya József (1964-) (szakorvos, klinikai mikrobiológus) Gergely Lajos (1940-) (szakorvos, klinikai mikrobiológus) Szarka Krisztina (1971-) (molekuláris biológus, mikrobiológus)
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