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001-es BibID:BIBFORM049348
035-os BibID:(PMID)23955198 (Scopus)84896034980 (WOS)000329356600017
Első szerző:Bárdi Edit (csecsemő- és gyermekgyógyász)
Cím:Value of FDG-PET/CT Examinations in Different Cancers of Children, Focusing on Lymphomas / Edit Bárdi, Mónika Csóka, Ildikó Garai, István Szegedi, Judit Müller, Tamás Györke, Kornélia Kajáry, Karolina Nemes, Csongor Kiss, Gábor Kovács
Dátum:2014
ISSN:1219-4956 1532-2807
Megjegyzések:The aim of the study was to assess sensitivity and specificity of FDG-PET/CT in different forms of childhood cancer. We retrospectively evaluated the results dedicated of 162 FDG-PET/CT examinations of 86 children treated with: Hodgkin lymphoma (HL; n=31), non-Hodgkin lymphoma (NHL; n=30) and other high grade solid tumors (n=25). Patients were admitted and treated in two departments of pediatric hematology and oncology in Hungary. FDG-PET/CT was performed for staging (n=25) and for posttreatment evaluation (n=137). Imaging was performed in three FDG-PET/CT Laboratories, using dedicated PET/CT scanners. False positive results were defined as resolution or absence of disease progression over at least 1 year on FDG-PET/CT scans without any intervention. In some cases histopathological evaluation of suspicious lesions was performed. Fals negative results were defined as negative FDG-PET/CT results in case of active malignancy. Positive predictive values (PPV) and negative predictive values (NPV) were calculated. NPV was 100 %. The highest PPV was observed in high grade solid tumors (81 %), followed by HL (65 %) and NHL (61 %). There was a major difference of PPV in different histological types of HL (50 % in HL of mixed-cellularity subtype, 90 % in nodular sclerosing, and 100 % in lymphocyte-rich and lymphocyte depleted HL). We treated one patient with nodular lymphocyte predominant HL, who had 5 false positive FDG-PET/CT results. PPV of T- and B-lineage NHL were similar (60 % and 62 %, respectively). We observed an interesting difference of PPV in different stages of HL and NHL. In HL PPV was higher in early than in advanced disease forms: 66 % in stage II HL and 60 % in stage III HL, whereas there was an inverse relationship between PPV and disease stages in NHL 0 % in stage I and II patients, 67 % in stage III and 100 % in stage IV patients. PPV was lower in males (54 %) than in females (65 %). PPV were 64 % vs. 58 % in patients under vs. over 10 years of age. Negative FDG-PET/CT results during follow-up reliably predict the absence of malignancy. Positive FDG-PET/CT scan results in general have a low PPV. The relatively high PPV in patients with histologically proven high grade solid tumors, advanced stages of NHL and with nodular sclerosing, lymphocyte-rich and lymphocyte depleted subtypes of HL warrant a confirmation by biopsy, whereas the watch-and-wait approach can be used in other forms of childhood cancer patients with a positive FDG-PET/CT result in course of follow-up examinations.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
FDG-PET/CT
Megjelenés:Pathology Oncology Research. - 20 : 1 (2014), p. 139-143. -
További szerzők:Csóka Mónika Garai Ildikó (1966-) (radiológus) Szegedi István (1969-) (hematológus, onkológus, nefrológus) Müller Judit Györke Tamás Kajáry Kornélia Nemes Karolina Kiss Csongor (1956-) (hematológus, onkológus) Kovács Gábor (gyermekhaematológus Budapest)
Pályázati támogatás:TÁMOP-4.2.2.A-11/1/KONV-2012-0025
TÁMOP
Internet cím:Szerző által megadott URL
DOI
Intézményi repozitóriumban (DEA) tárolt változat
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2.

001-es BibID:BIBFORM011927
Első szerző:Bárdi Edit (csecsemő- és gyermekgyógyász)
Cím:Differential Effect of Corticosteroids on Serum Cystatin C in Thrombocytopenic Purpura and Leukemia / Bárdi E., Dobos E., Kappelmayer J., Kiss C.
Dátum:2010
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Pathology and Oncology Research. - 16 : 3 (2010), p. 453-456. -
További szerzők:Dobos Éva Kappelmayer János (1960-) (laboratóriumi szakorvos) Kiss Csongor (1956-) (hematológus, onkológus)
Internet cím:Intézményi repozitóriumban (DEA) tárolt változat
DOI
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3.

001-es BibID:BIBFORM001928
Első szerző:Bárdi Edit (csecsemő- és gyermekgyógyász)
Cím:Anthracycline antibiotics induce acute renal tubular toxicity in children with cancer / Bárdi E., Bobok I., V. Oláh A., Kappelmayer J., Kiss C.
Dátum:2007
Megjegyzések:Experimental evidence suggests that anthracyclines, widely used in cancer chemotherapy, may impair kidney function. We assessed kidney function by serum creatinine, urinary N-acetyl-?-D-glucosaminidase activity indices (NAGi) and microalbuminuria (MA) in 160 serum and urine samples obtained from 66 children with cancer. The effect of dexrazoxane was analyzed in 6 children on dexrazoxane supportive therapy in conjunction with daunorubicin (DNR) treatment, as compared with 6 children notreceiving this agent. NAGi was significantly (p<0.05) elevated after treatment by DNR, doxorubicin, epirubicin (EPI) and idarubicin (IDA). MA proved to be a less sensitive indicator of kidney damage than NAGi. DNR resulted in a progressive deterioration of proximal tubular function as determined by linear regression analysis. The mean NAGi in the dexrazoxanetreated group was significantly (p<0.005) lower than in children not receiving dexrazoxane prior to DNR treatment. In conclusion, our study demonstrated that DNR, EPI and IDA induced an acute renal tubular damage similar to known tubulotoxic agents as cisplatin, carboplatin, cyclophosphamide and ifosfamide. The damage was clinically mild and only a minor proportion of patients can be expected to develop long-lasting tubulopathy with negative impact on the quality of life.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
nephrotoxicity
anthracycline therapy
dexrazoxane
NAGi
microalbuminuria
egyetemen (Magyarországon) készült közlemény
Megjelenés:Pathology and Oncology Research. - 13 : 3 (2007), p. 249-253. -
További szerzők:Bobok Ildikó Oláh Anna (1956-) (klinikai biokémikus, vegyész) Kappelmayer János (1960-) (laboratóriumi szakorvos) Kiss Csongor (1956-) (hematológus, onkológus)
Internet cím:elektronikus változat
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4.

001-es BibID:BIBFORM040735
Első szerző:Jenei Zoltán (belgyógyász)
Cím:Anthracycline causes impaired vascular endothelial function and aortic stiffnes in long term survivors of childhood cancer / Zoltán Jenei, Edit Bárdi, Mária Tünde Magyar, Ágnes Horváth, György Paragh, Csongor Kiss
Dátum:2013
ISSN:1532-2807
Megjegyzések:Vascular and endothelial functions were investigated in long term survivors of childhood cancer exposed to anthracycline treatment. We enrolled 96 long-term survivors (57 males and 39 females, mean age 14.9±5.3 year) of different childhood cancers and 72 age-, sex-, bodyweight- and blood pressure matched controls (39 males and 33 females, mean age 13.7±4.9 year). Aortic stiffness was characterized by echocardiography. Brachial artery endothelial function was assessed by flow-mediated dilatation (FMD%) and nitrate-mediated dilatation (NTG%). Results were compared between three subgroups: anthracycline treated, only chemotherapy treated and control subgroups. The cumulative anthracycline dose was less than 350 mg/m(2). The healthy control subgroup had a significantly greater FMD response (13.13±2.40 %), and lower stiffness index (2.08±0.6) than both the anthracycline (7.12±6.28 % and 6.45±3.25, respectively) and only chemotherapy treated (10.17±4.23 % and 4.12±2.32, respectively) subgroups. In the anthracycline treated subgroup a significantly (p<0.01) lower FMD% response, and higher stiffness index were detected than in the only chemotherapy treated subgroup. Higher triglyceride level, higher cumulative anthracycline dose and lower age at the start of treatment were found to be associated independently with impairment of FMD% response and aortic stiffness. We found a significant negative correlation between FMD and aortic stiffness (p<0.001) and a positive correlation between FMD and distensibility (p<0.0001) Childhood cancer long term survivors exposed to anthracycline treatment exhibit a marked preclinical vasculopathy, characterized by endothelial dysfunction and increased arterial stiffness, contributing to a deteriorated cardiovascular function.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Egészség- és Környezettudomány
Megjelenés:Pathology & Oncology Research. - 19 : 3 (2013), p. 375-383. -
További szerzők:Bárdi Edit (1971-) (csecsemő- és gyermekgyógyász) Magyar Mária Tünde (1970-) (neurológus) Horváth Ágnes (1985-) (reumatológus) Paragh György (1953-) (belgyógyász) Kiss Csongor (1956-) (hematológus, onkológus)
Pályázati támogatás:ETT 396/2006
Egyéb
01-478/2009
Egyéb
TÁMOP-4.2.1/B-09/1/KONV-2010-0007
TÁMOP
Rosszindulatú daganatos megbetegedések serdülő és fiatal felnőttkorban
Internet cím:Intézményi repozitóriumban (DEA) tárolt változat
Szerző által megadott URL
DOI
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5.

001-es BibID:BIBFORM002279
Első szerző:Rényi Imre (gyermekhaematológus Budapest)
Cím:Prevention and treatment of hyperuricemia with rasburicase in children with leukemia and Non-Hodgkin's lymphoma / Rényi Imre, Bárdi Edit, Udvardy Erzsébet, Kovács Gábor, Bartyik Katalin, Kajtár Pál, Masát Péter, Nagy Kálmán, Galántai Ilona, Kiss Csongor
Dátum:2007
Megjegyzések:To prevent acute renal failure in children at risk for developing tumor lysis syndrome due to acute lymphoblastic leukemia or non-Hodgkin's lymphoma treated according to international BFM protocols, we investigated recombinant urate oxidase (rasburicase) in the first Central European openlabeled, prospective, multicenter phase IV trial. Rasburicase was administered intravenously, at 0.2 mg/kg for 5 consecutive days to 36 patients. Blood levels of uric acid, creatinine, phosphorus, calcium lactate dehydrogenase and complete blood count were measured daily during rasburicase treatment and on days 6, 7 and 12. Initial uric acid level decreased significantly by 4 hours (from 343 gamma mol/L to 58 gamma mol/L, p<0.001), except for one steroid-resistant patient who required hemodialysis on day 14 after having introduced combined cytostatic treatment. Comparing the data of a subgroup of 12 patients receiving rasburicase with that of a historic cohort of 14 patients treated with allopurinol indicated the superiority of rasburicase over allopurinol in prophylaxis and treatment of hyperuricemia in children with leukemia and lymphoma.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
rasburicase
uric acid
tumor lysis syndrome
leukemia
lymphoma
Megjelenés:Pathology and Oncology Research 13 : 1 (2007), p. 57-62. -
További szerzők:Bárdi Edit (1971-) (csecsemő- és gyermekgyógyász) Udvardy Erzsébet Kovács Gábor Bartyik Katalin (haematológus) Kajtár Pál Masát Péter (gyermekorvos Szombathely) Nagy Kálmán Galántai Ilona (onkológus Budapest) Kiss Csongor (1956-) (hematológus, onkológus)
Internet cím:elektronikus változat
elektronikus változat
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