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1.

001-es BibID:BIBFORM042525
035-os BibID:PMID: 12730763
Első szerző:Berczi Csaba (urológus, sebész, onkológus)
Cím:Comparison of calcium and alfacalcidol supplement in the prevention of osteopenia after kidney transplantation / Berczi C., Asztalos L., Kincses Z., Balogh A., Löcsey L., Balázs G., Lukács G.
Dátum:2003
ISSN:0937-941X
Megjegyzések:The aim of this observational study was to compare the effect of calcium and alfacalcidol supplementation on the regression of hyperparathyroidism and on prevention of osteopenia in patients up to 3 years after renal transplantation. Two historical cohorts were compared for that purpose. One hundred and fifty-nine patients received calcium carbonate supplement (group 1), while 81 patients were treated with alfacalcidol (group 2). Serum Ca, phosphate (P), Mg, creatinine, alkaline phosphatase (AP) and parathyroid hormone (PTH) levels were determined before and after transplantation in the two groups, for 3 years. Femoral neck and lumbar spine bone mineral density (BMD) was measured only at 3 and 6 months and 1, 2 and 3 years after transplantation. At baseline there was no difference in age or sex ratio, but prevalence in post-menopausal women was higher in group 1 (6.9% versus 1.2%). Duration on dialysis was comparable but prevalence of interstitial and undetermined nephropathies was higher in group 1. Baseline serum concentrations of PTH, Ca and P were comparable in both groups. After transplantation, plasma creatinine decreased to comparable levels in both groups. Immunosuppression by triple therapy was more prevalent in group 2, so that cumulative dose of steroid was higher in group 1, especially at 1 month because of higher incidence of acute rejections (51% versus 13%). Mean intact PTH levels decreased in both groups, from 18 pmol/l to 8.4 and 7.9 at 3 years, but the decrease was significantly greater with alfacalcidol at 6 and 12 months. At 3 months, BMD were comparable at both sites. From 3 months to 3 years after kidney transplantation, mean lumbar spine BMD significantly increased from 0.963 to 1.054 g/cm(2) in group 1, whereas there was no significant decrease (1.048 to 1.006 g/cm(2)) in group 2, the difference in changes being significant ( P<0.05). Femoral neck BMD was not significantly increased in either group (0.932 to 0.993 g/cm(2) in group 1, and 0.850 to 0.907 g/cm(2) in group 2). Expressed as percentages, these changes were +9.4% and -4% for lumbar BMD and +6.5% and +6.7% for femoral neck, for groups 1 and 2, respectively. Prevalence of osteopenia was not significantly lower at 3 years in group 1 (45% and 51%) than in group 2. During the follow-up period, osteonecrosis was diagnosed in six patients (3.8%) in group 1 and in nine (11%) in group 2. In conclusion, alfacalcidol compared to CaCO3 supplement suppressed hyperparathyroidism more rapidly and strongly. In spite of higher osteopenia risk in the CaCO3 group, lumbar BMD increase was greater and incidence of osteonecrosis higher in this group, suggesting better bone protection with CaCO3 than with alfacalcidol.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Osteoporosis International. - 14 : 5 (2003), p. 412-417. -
További szerzők:Asztalos László (1951-) (sebész) Kincses Zsolt (1961-) (orvos) Balogh Ádám (1940-) (szülész-nőgyógyász, endokrinológus szakorvos) Lőcsey Lajos (1946-2013) (belgyógyász, nephrológus) Balázs György (1933-) (sebész) Lukács Géza (1941-) (sebész)
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2.

001-es BibID:BIBFORM035368
035-os BibID:WOS:000221453600189
Első szerző:Bhattoa Harjit Pal (laboratóriumi szakorvos)
Cím:Examination of the effect of dietary habits on bone mineral density inhealthy men aged 15 to 49 years living in the city of Debrecen (M341) / H. P. Bhattoa, Á. Balogh
Dátum:2007
ISSN:0937-941X
Tárgyszavak:Orvostudományok Klinikai orvostudományok idézhető absztrakt
Endocrinology & Metabolism
egyetemen (Magyarországon) készült közlemény
Megjelenés:Journal of Bone and Mineral Research. Supplementum. - 22 : Suppl. 1 (2007), p. S197. -
További szerzők:Balogh Ádám (1940-) (szülész-nőgyógyász, endokrinológus szakorvos)
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3.

001-es BibID:BIBFORM035324
Első szerző:Bhattoa Harjit Pal (laboratóriumi szakorvos)
Cím:The effect of 1-year transdermal estrogen replacement therapy on bone mineral density and biochemical markers of bone turnover in osteopenic postmenopausal systemic lupus erythematosus patients : a randomized, double-blind, placebo-controlled trial / H. P. Bhattoa, P. Bettembuk, A. Balogh, Gy. Szegedi, E. Kiss
Dátum:2004
ISSN:0937941X
Megjegyzések:We studied the effect of 1-year transdermal estrogen replacement therapy (ERT) on bone mineral density (BMD) and biochemical markers of bone turnover in osteopenic postmenopausal systemic lupus erythematosus (SLE) patients in a randomized, double-blind, placebo-controlled trial. SLE patients were randomly allocated to treatment (estradiol; 50 ??g transdermal 17??-estradiol; n = 15) or placebo (n = 17) group. Both groups received 5 mg continuous oral medroxyprogesterone acetate, 500 mg calcium and 400 IU vitamin D3, L1-L4 spine (LS), left femur and total hip BMD were measured at baseline and at 6 and 12 months. Serum osteocalcin (OC) and degradation products of C-terminal telopeptides of type-I collagen (CTx) levels were measured at baseline and 3, 6, 9, and 12 months. There was a significant difference in the percentage change of LS BMD at 6 months between the two groups (103.24 ?? 3.74% (estradiol group) vs 98.99 ?? 3.11% (placebo group); P &lt; 0.005). There was a significant decrease within the estradiol group in the CTx levels between baseline and all subsequent visits (P &lt; 0.05). There was no significant difference in SLE disease activity index, Systemic Lupus International Collaborating Clinics/American College of Rheumatology (ACR) damage index and corticosteroid dose during the study period, Transdermal estradiol may prevent bone loss in postmenopausal SLE women at the lumbar spine and femur, with no increase in disease activity among postmenopausal SLE women receiving transdermal ERT. The high dropout rate (8/15) leads us to the conclusion that efficacy of HRT in a high-risk group such as SLE women can be attained only in a small number of patients, provided all inclusion/exclusion criteria are strictly adhered to.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Biochemical markers of bone turnover
Bone mineral density
Osteopenia
Postmenopausal Systemic lupus erythematosus
Transdermal estrogen replacement therapy
biological marker
calcium
carboxy terminal telopeptide
collagen type 1
corticosteroid
estradiol
medroxyprogesterone acetate
osteocalcin
placebo
vitamin D
adult
aged
article
bone density
bone mineral
bone turnover
carboxy terminal sequence
clinical trial
controlled clinical trial
controlled study
disease activity
double blind procedure
drug effect
drug efficacy
estrogen therapy
female
femur
hip
human
lumbar spine
medical society
osteolysis
osteopenia
postmenopause
priority journal
prophylaxis
protein blood level
randomization
randomized controlled trial
systemic lupus erythematosus
Administration, Cutaneous
Adult
Aged
Biological Markers
Bone Density
Bone Remodeling
Double-Blind Method
Estradiol
Estrogen Replacement Therapy
Female
Femur Neck
Hip Joint
Humans
Lumbar Vertebrae
Lupus Erythematosus, Systemic
Middle Aged
Osteoporosis, Postmenopausal
egyetemen (Magyarországon) készült közlemény
Megjelenés:Osteoporosis International. - 15 : 5 (2004), p. 396-404. -
További szerzők:Bettembuk Péter Balogh Ádám (1940-) (szülész-nőgyógyász, endokrinológus szakorvos) Szegedi Gyula (1936-2013) (belgyógyász, immunológus) Kiss Emese (1960-) (belgyógyász, immunológus)
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4.

001-es BibID:BIBFORM035323
035-os BibID:PMID:15205715
Első szerző:Bhattoa Harjit Pal (laboratóriumi szakorvos)
Cím:Prevalence and seasonal variation of hypovitaminosis D and its relationship to bone metabolism in community dwelling postmenopausal Hungarian women / H. P. Bhattoa, P. Bettembuk, S. Ganacharya, A. Balogh
Dátum:2004
ISSN:0937941X
Megjegyzések:Hypovitaminosis D can result in low bone mass. The prevalence of hypovitaminosis D has public health implications, especially where data are lacking. Since diet and sunlight are the two souces of vitamin D, the results obtained in one geographical region may not be universally applicable. The aim of this study is to characterize the prevalence and seasonal variation of hypovitaminosis D and its relationship to bone metabolism in community dwelling postmenopausal Hungarian women. We determined serum levels of 25-hydroxyvitamin D (25-OH-D), PTH, osteocalcin (OC), degradation products of C-terminal telopeptides of type-I collagen (CTx), dietary calcium intake and BMD at L2-L4 lumbar spine (LS) and femur neck (FN) in 319 randomly selected ambulatory postmenopausal women. The prevalence of hypovitaminosis D (serum 25-OH-D ?ë♯n 50 nmol/1) was 56.7%. On comparing patients with normal and low 25-OH-D, a significant difference was found in age (61.6 ?? 8.5 years versus 67.3 ?? 9.9 years; P &lt; 0.001), PTH (3.9 ?? 1.9 pmol/l versus 4.3 ?? 2.7 pmol/l; P &lt; 0.05), FN BMD (0.802 ?? 0.123 g/cm2 versus 0.744 ?? 0.125 g/cm2; P &lt; 0.001) and dietary calcium intake (714.4 ?? 199.4 g/day versus 607.9 ?? 233 g/day; P &lt; 0.001). Osteoporotic patients had a significantly lower 25-OH-D (37.6 ?? 19.8 nmol/l versus 56.4 ?? 24 nmol/l; P &lt; 0.001) and dietary calcium intake (519.2 ?? 244.5 mg/day versus 718.2 ?? 164.3 mg/day; P &lt; 0.001). After controlling for all other variables, 25-OH-D was found to be significantly associated with age, the average hours of sunshine in the 3 months prior to 25-OH-D level determination and dietary calcium intake (r2 = 0. 190; P &lt; 0.001). For FN BMD, significant independent predictors were age, body mass index, 25-OH-D and dietary calcium intake (r2 = 0.435; P &lt; 0.001). The prevalence of hypovitaminosis D during spring, summer, autumn and winter was 71%, 46.3%, 49.4% and 56.7%, respectively. There was significant seasonal variation in 25-OH-D, PTH, OC, calcium intake and FN BMD. There is a high prevalence of hypovitaminosis D in healthy postmenopausal Hungarian women, and FN BMD is associated with serum 25-OH-D and dietary calcium intake.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Biochemical markers of bone turnover
Bone mineral density
Hypovitaminosis D
Postmenopausal
Seasonal variation
25 hydroxyvitamin D
calcium
carboxy terminal telopeptide
collagen type 1
osteocalcin
parathyroid hormone
vitamin D
adult
aged
article
autumn
bone mass
bone metabolism
bone turnover
calcium intake
community
controlled study
dietary intake
female
femur neck
geographic distribution
human
Hungary
lumbar spine
major clinical study
osteoporosis
postmenopause
prevalence
priority journal
public health
seasonal variation
spring
summer
sunlight
vitamin D deficiency
winter
Adult
Aged
Aged, 80 and over
Biological Markers
Bone and Bones
Bone Density
Calcium
Collagen
Collagen Type I
Diet
Female
Femur Neck
Humans
Hungary
Middle Aged
Osteocalcin
Parathyroid Hormone
Peptides
Postmenopause
Prevalence
Seasons
Vitamin D
Vitamin D Deficiency
egyetemen (Magyarországon) készült közlemény
Megjelenés:Osteoporosis International. - 15 : 6 (2004), p. 447-451. -
További szerzők:Bettembuk Péter Ganacharya, Sanjay Balogh Ádám (1940-) (szülész-nőgyógyász, endokrinológus szakorvos)
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5.

001-es BibID:BIBFORM035054
035-os BibID:PMID:22422303
Első szerző:Bhattoa Harjit Pal (laboratóriumi szakorvos)
Cím:Prevalence and seasonal variation of hypovitaminosis D and its relationship to bone metabolism in healthy Hungarian men over 50 years of age : the HunMen Study / H. P. Bhattoa, E. Nagy, C. More, J. Kappelmayer, A. Balogh, E. Kalina, P. Antal-Szalmas
Dátum:2013
ISSN:0937-941X
Megjegyzések:This study reports a high prevalence of hypovitaminosis D and low bone mineral density (BMD) in a healthy Hungarian male cohort over 50 years of age. Men with 25-hydroxyvitamin D levels of <75 nmol/L had a significantly higher 10-year hip and major osteoporotic fracture probability using the country-specific fracture risk assessment (FRAX) algorithm. INTRODUCTION: The aim of this study is to characterize the prevalence and seasonal variation of hypovitaminosis D and its relationship to bone metabolism in healthy Hungarian men over 50 years of age. METHODS: We determined levels of 25-hydroxyvitamin D (25-OH-D), PTH, osteocalcin (OC), C-terminal telopeptides of type-I collagen (CTX-I), procollagen type 1 amino-terminal propeptide (PINP), BMD at L1-L4 (LS) and femur neck (FN), daily dietary calcium intake, and the 10-year probability of hip fracture and a major osteoporotic fracture using the country-specific FRAX algorithm in 206 randomly selected ambulatory men. RESULTS: The mean (range) age of the volunteers was 60 (51-81) years. The prevalence of hypovitaminosis D (25-OH-D, <75 nmol/L) was 52.9%. The mean (range) FRAX hip fracture and FRAX major osteoporotic fracture was 0.8% (0-9.4%) and 3.8% (1.7-16%), respectively. On comparing the vitamin D sufficient to the insufficient group, there was a statistically significant difference between the FRAX hip fracture and FRAX major osteoporotic fracture indexes. There was significant seasonal variation in the vitamin D levels; the lowest levels were measured in winter and the highest in summer. CONCLUSIONS: A high prevalence of hypovitaminosis D and low BMD were observed in the studied Hungarian male population. This is the first study reporting higher 10-year hip and major osteoporotic fracture probability using the country-specific FRAX algorithm in individuals with hypovitaminosis D.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Molekuláris Medicina
Megjelenés:Osteoporosis International. - 24 : 1 (2013), p. 179-186. -
További szerzők:Nagy E. Móré Csaba (1971-) (szülész-nőgyógyász) Kappelmayer János (1960-) (laboratóriumi szakorvos) Balogh Ádám (1940-) (szülész-nőgyógyász, endokrinológus szakorvos) Kalina Edit Antal-Szalmás Péter (1968-) (laboratóriumi szakorvos)
Pályázati támogatás:TÁMOP-4.2.1/B-09/1/KONV-2010-0007
TÁMOP
Celluláris hematológia - immunológia
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6.

001-es BibID:BIBFORM068611
Első szerző:Jakab Éva
Cím:Standardizing 25-hydroxyvitamin D data from the HunMen cohort / E. Jakab, E. Kalina, Z. Petho, Z. Pap, A. Balogh, W. B. Grant, H. P. Bhattoa
Dátum:2017
ISSN:0937-941X
Megjegyzések:Summary Standardization of 25-hydroxyvitamin D (25OHD)values is still a challenge.We propose standardization by correctionof the measured 25OHD values using the linear regressionbias from the National Institute of Standards andTechnology (NIST) ♭total' target values reported by VitaminD External Quality Assessment Scheme (DEQAS). Our approachcould perhaps be a practical solution to the anomalysurrounding non-standardized 25OHD values.Introduction Standardization of 25OHD values is still a challenge.We propose standardization by correction of the measured25OHD values using the linear regression equation derivedfrom the analysis of relationship between total 25OHDvalues measured by the methodology used by the laboratoryand the NIST total target values (TV) reported by the DEQASfor all 5 of the DEQAS samples in a given survey.Methods We applied our approach to standardize total25OHD values of the HunMen cohort.Results All 206 samples for the HunMen cohort were evaluatedusing the automated Liaison DiaSorin total 25OHDchemiluminescence immunoassay (CLIA). The timing ofthese measurements coincided with that of the October 2015DEQAS survey using samples 481 to 485. Following standardization,the mean total 25OHD changed from 53 to62 nmol/L and the prevalence of hypovitaminosis D(<75 nmol/L) decreased significantly from 84 to 72%.Conclusion A simple approach readily applicable at the routinediagnostic laboratory could perhaps be a practical solutionto the anomaly surrounding non-standardized 25OHD values
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
25-Hydroxyvitamin D
DEQAS
HunMen
Standardization
Megjelenés:Osteoporosis International. - 28 : 5 (2017), p. 1653-1657. -
További szerzők:Kalina Edit Pethő Zsófia (1981-) (reumatológus, immunológus) Pap Zoltán Domokos (1973-) Balogh Ádám (1940-) (szülész-nőgyógyász, endokrinológus szakorvos) Grant, William B. Bhattoa Harjit Pal (1973-) (laboratóriumi szakorvos)
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7.

001-es BibID:BIBFORM035330
Első szerző:Móré Csaba (szülész-nőgyógyász)
Cím:The effects of pregnancy and lactation on bone mineral density / C. More, P. Bettembuk, H. P. Bhattoa, A. Balogh
Dátum:2001
ISSN:0937-941X
Megjegyzések:We performed a prospective study of bone mineral density (BMD) in 38 women during their first full-term pregnancy until 12 months postpartum. BMD measurements at lumbar spine [L2-L4 (LS)] and forearm [distal 33% (RD) and ultradistal (RUD) region of the radius] were made within 3 months before conception, after delivery, and at 6 and 12 months postpartum. In mid-pregnancy the DXA examination was carried out only at the forearm. Patients were grouped according to duration of lactation as group I, II or III (0-1, 1-6, 6-12 months respectively). During pregnancy there was a significant difference between baseline and delivery (p<0.001) in the LS, RUD and RD BMD values. In group I there was no statistically significant difference in LS BMD between visits following pregnancy. The RUD BMD loss was recovered by 6 months postpartum (PP6). Group II showed continuous bone loss from delivery until PP6 at LS and RUD. In group III the LS BMD loss continued throughout the lactation period. The RUD BMD dropped (4.9%) until PP6 then increased by 3.0% as measured at 12 months postpartum (PP12). There was no significant change in RD BMD in any of three groups during lactation. At LS bone loss between delivery and PP12 correlated well with the duration of lactation (r=-0.727; p<0.001). We suggest that calcium needed for fetal skeletal growth during pregnancy was gained from maternal trabecular and cortical sites and that calcium needed for infant growth during lactation was drawn mainly from the maternal trabecular skeleton in our patients. The effect of pregnancy and lactation on the maternal bone mass was spontaneously compensated after weaning.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Bone mineral density
Lactation
Pregnancy
adult
article
bone atrophy
bone density
bone growth
bone mineralization
calcium mobilization
controlled study
cortical bone
dual energy X ray absorptiometry
female
fetus growth
human
lactation
lumbar spine
pregnancy
priority journal
puerperium
trabecular bone
weaning
Adult
Bone Density
Densitometry, X-Ray
Female
Humans
Lactation
Pregnancy
Prospective Studies
egyetemen (Magyarországon) készült közlemény
Megjelenés:Osteoporosis International. - 12 : 9 (2001), p. 732-737. -
További szerzők:Bettembuk Péter Bhattoa Harjit Pal (1973-) (laboratóriumi szakorvos) Balogh Ádám (1940-) (szülész-nőgyógyász, endokrinológus szakorvos)
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8.

001-es BibID:BIBFORM059613
Első szerző:Pethő Zsófia (reumatológus, immunológus)
Cím:Vitamin D status in men with psoriatic arthritis : a case-control study / Z. Petho, E. Kulcsar-Jakab, E. Kalina, A. Balogh, A. Pusztai, K. Gulyas, A. Horvath, Z. Szekanecz, H. P. Bhattoa
Dátum:2015
ISSN:0937-941X
Megjegyzések:Summary: We determined hypovitaminosis D prevalence inmen with psoriatic arthritis. This is a cross-sectional, analystblinded, age- and sex-matched, case-control study. Men withpsoriatic arthritis have significantly lower 25-hydroxyvitaminD levels. Men with psoriatic arthritis are at increased odds ofsuffering from hypovitaminosis D.Introduction: Skeletal manifestations as a result of abruptedbone metabolism may be predominant in psoriatic arthritis(PsA). Vitamin D plays a vital role in maintenance of skeletalhealth and is known to modulate the immune system in variousautoimmune diseases including PsA. The aim of the presentstudy was to determine the prevalence of hypovitaminosisD in a treatment naïve, de novo psoriatic arthritis male cohortin a cross-sectional, analyst blinded, age- and sex-matched,case-control study.Methods: 25 hydroxyvitamin D (25OHD), parathyroid (PTH),osteocalcin (OC) and C-terminal telopeptides of type-I collagen(CTx) levels, and lumbar spine and femoral neck bonemineral density were compared between 53 PsA and controls.Results: The prevalence of hypovitaminosis D (25hydroxyvitamin D (25OHD) levels <75 nmol/L) was 81 and57 % in the PsA and control groups, respectively. Comparedto the healthy controls, 25OHD (67.2 (12?137) nmol/L vs.51.9 (15?95) nmol/L; p=0.001) was significantly lower, andosteocalcin (13.6 (5?33) ?g/L vs. 18.2 (6?35) ?g/L; p=0.003)and C-terminal telopeptides of type-I collagen (0.20 (0.01?0.71) ?g/L vs. 0.28 (0.06?0.69) ?g/L; p=0.008) were significantlyhigher in the PsA group. A significant association wasfound between hypovitaminosis D and PsA; the odds for patientswith PsA of having hypovitaminosis D was 3.297 (95%confidence interval 1.372 to 7.922).Conclusion: The results of this study suggest that men withPsA have significantly lower 25-hydroxyvitamin D levels,and furthermore, men with PsA are at statistically significantincreased odds of suffering from hypovitaminosis D.
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
bone markers
bone mineral density
men
psoriatic arthritis
vitamin D
Megjelenés:Osteoporosis International. - 26 : 7 (2015), p. 1965-1970. -
További szerzők:Jakab Éva (1969-) Kalina Edit Balogh Ádám (1940-) (szülész-nőgyógyász, endokrinológus szakorvos) Karancsiné Pusztai Anita (1989-) (tudományos segédmunkatárs) Gulyás Katalin (reumatológus) Horváth Ágnes (1985-) (reumatológus) Szekanecz Zoltán (1964-) (reumatológus, belgyógyász, immunológus) Bhattoa Harjit Pal (1973-) (laboratóriumi szakorvos)
Pályázati támogatás:OTKA-105073
OTKA
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9.

001-es BibID:bibEBI00019025
Első szerző:Reginster, Jean-Yves
Cím:Strontium ranelate reduces the risk of vertebral fractures in osteoporotic postmenopausal women without prevalent vertebral fracture / Reginster J.-Y., Rizzoli R., Balogh Á., Badurski J., Spector T., Tulassay Z., Felsenberg D., Cannata J. B., Phenekos C., Ortolani S., Meunier P. J.
Dátum:2005
Tárgyszavak:Orvostudományok Elméleti orvostudományok idézhető absztrakt
Megjelenés:Osteoporosis International. - 16 : Suppl.3 (2005), p. S53. -
További szerzők:Rizzoli, Rene Balogh Ádám (1940-) (szülész-nőgyógyász, endokrinológus szakorvos) Badurski, Janusz E. Spector, Thomas Tulassay Zsolt (1944-) (belgyógyász, gasztroenterológus) Felsenberg, Dieter Cannata, Jorge B. Phenekos, Costas Ortolani, S. Meunier, Pierre J.
Borító:

10.

001-es BibID:BIBFORM042521
035-os BibID:PMID:22124575
Első szerző:Reginster, J-Y.
Cím:Maintenance of antifracture efficacy over 10 years with strontium ranelate in postmenopausal osteoporosis / Reginster, J-Y., Kaufman, J-M., Goemaere, S., Devogelaer, J. P., Benhamou, C. L., Felsenberg, D., Diaz-Curiel, M., Brandi, M-L., Badurski, J., Wark, J., Balogh, A., Bruyère, O., Roux, C.
Dátum:2012
ISSN:0937-941X
Megjegyzések:In an open-label extension study, BMD increased continuously with strontium ranelate over 10 years in osteoporotic women (P < 0.01). Vertebral and nonvertebral fracture incidence was lower between 5 and 10 years than in a matched placebo group over 5 years (P < 0.05). Strontium ranelate's antifracture efficacy appears to be maintained long term.INTRODUCTION:Strontium ranelate has proven efficacy against vertebral and nonvertebral fractures, including hip, over 5 years in postmenopausal osteoporosis. We explored long-term efficacy and safety of strontium ranelate over 10 years.METHODS:Postmenopausal osteoporotic women participating in the double-blind, placebo-controlled phase 3 studies SOTI and TROPOS to 5 years were invited to enter a 5-year open-label extension, during which they received strontium ranelate 2 g/day (n = 237, 10-year population). Bone mineral density (BMD) and fracture incidence were recorded, and FRAX? scores were calculated. The effect of strontium ranelate on fracture incidence was evaluated by comparison with a FRAX?-matched placebo group identified in the TROPOS placebo arm.RESULTS:The patients in the 10-year population had baseline characteristics comparable to those of the total SOTI/TROPOS population. Over 10 years, lumbar BMD increased continuously and significantly (P < 0.01 versus previous year) with 34.5 ? 20.2% relative change from baseline to 10 years. The incidence of vertebral and nonvertebral fracture with strontium ranelate in the 10-year population in years 6 to 10 was comparable to the incidence between years 0 and 5, but was significantly lower than the incidence observed in the FRAX?-matched placebo group over 5 years (P?<?0.05); relative risk reductions for vertebral and nonvertebral fractures were 35% and 38%, respectively. Strontium ranelate was safe and well tolerated over 10 years.CONCLUSIONS:Long-term treatment with strontium ranelate is associated with sustained increases in BMD over 10 years, with a good safety profile. Our results also support the maintenance of antifracture efficacy over 10 years with strontium ranelate.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Osteoporosis International 23 : 3 (2012), p. 1115-1122. -
További szerzők:Kaufman, J-M. Goemaere, Stefan Devogelaer, Jean-Pierre Benhamou, C. L. Felsenberg, Dieter Diaz-Curiel, M. Brandi, M-L. Badurski, Janusz E. Wark, J. Balogh Ádám (1940-) (szülész-nőgyógyász, endokrinológus szakorvos) Bruyère, Olivier Roux, Christian
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