CCL

Összesen 8 találat.
#/oldal:
Részletezés:
Rendezés:

1.

001-es BibID:BIBFORM092841
035-os BibID:(cikkazonosító)615177
Első szerző:Árokszállási Tamás (neurológus)
Cím:Prognostic value of various hemostasis parameters and neurophysiological examinations in spontaneous intracerebral hemorrhage : the IRONHEART study protocol / Tamás Árokszállási, Máté Héja, Zsuzsa Bagoly, Kitti Bernadett Kovács, Rita Kálmándi, Ferenc Sarkady, Judit Tóth, Klára Fekete, István Fekete, Laszlo Csiba
Dátum:2021
ISSN:1664-2295
Megjegyzések:Rationale: Stroke is the leading cause of death in all developed countries. In Hungary, more than 10000 patients die annually due to cerebrovascular diseases according to the WHO Mortality Database. 10-15 % of these patients suffer non-traumatic intracerebral hemorrhage (ICH). ICH results in a higher rate of mortality as compared to ischemic stroke and outcomes are difficult to predict. In the GINOP IRONHEART study, we aim to test various hemostasis parameters and clinical neurophysiological examinations in evaluating outcome in intracerebral haemorrhage. Methods: In this prospective, observational study, we plan to enroll consecutive patients with non-traumatic spontaneous intracerebral hemorrhage admitted to a single Stroke Center (Department of Neurology, University of Debrecen, Hungary). The protocol of the GINOP IRONHEART study includes the investigation of detailed clinical, laboratory investigations, and various neurophysiological examiniations. Stroke severity is quantified based on the National Institutes of Health Stroke Scale (NIHSS) on admisson and day 7, 14, 90 after the onset of stroke. Cranial CT is performed on admission, day 14, and 90 to estimate the ICH volume. Modified Rankin Score (mRS) is used for evaluating the long-term outcome (90 days post-event). Blood is drawn immediately on admission for specific hemostasis tests. Digital and quantitative EEG techniques and motor evoked potential (MEP) are performed to evaluate the prognosis of cerebral hemorrhage on admission (within 24-28h), immediately before discharge (??10?14 days later), and 3 months after the event. Outcomes: The following outcomes are investigated: 1/ Mortality by day 14 and day 90 2/ Long-term outcome at 90 days post-event: mRS 0-1 is defined as favorable long-term outcome. Discussion: If associations between outcomes and the investigated parameters (hemostasis and neurophysiological examinations) are confirmed, results might aid prognosis assessment in this subtype of stroke with particularly high mortality. Improving clinical grading systems on ICH severity and outcomes by including the investigated parameters could help to better guide the management of these patients in the future.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:Frontiers in Neurology. - 12 (2021), p. 1-6. -
További szerzők:Héja Máté (1991-) (általános orvos) Bagoly Zsuzsa (1978-) (orvos) Kovács Kitti Bernadett (1985-) (neurológus) Orbán-Kálmándi Rita Angéla (1993-) (klinikai laboratóriumi kutató) Sarkady Ferenc (1982-) (laboratóriumi analitikus) Tóth Judit (1964-) (radiológus) Fekete Klára (1978-) (neurológus) Fekete István (1951-) (neurológus, pszichiáter) Csiba László (1952-) (neurológus, pszichiáter)
Pályázati támogatás:GINOP-2.3.2-15-2016-00043
GINOP
Internet cím:Intézményi repozitóriumban (DEA) tárolt változat
DOI
Borító:

2.

001-es BibID:BIBFORM079710
035-os BibID:(cikkazonosító)513 (WOS)000472470100001 (Scopus)85069171973 (PMID)31316444
Első szerző:Bagoly Zsuzsa (orvos)
Cím:Markers of Coagulation and Fibrinolysis Predicting the Outcome of Acute Ischemic Stroke Thrombolysis Treatment : a Review of the Literature / Bagoly Zsuzsa, Szegedi István, Kálmándi Rita, Tóth Noémi Klára, Csiba László
Dátum:2019
ISSN:1664-2295
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
thrombolysis
coagulation
fibrinolysis
stroke
outcome
Megjelenés:Frontiers in Neurology. - 10 (2019), p. 1-13. -
További szerzők:Szegedi István (1992-) (orvos) Orbán-Kálmándi Rita Angéla (1993-) (klinikai laboratóriumi kutató) Tóth Noémi Klára Csiba László (1952-) (neurológus, pszichiáter)
Pályázati támogatás:NKFIH K109712, K120042, FK128582
Egyéb
GINOP-2.3.2-15-2016-00048
GINOP
GINOP-2.3.2-15-2016-00043
GINOP
Internet cím:Szerző által megadott URL
DOI
Intézményi repozitóriumban (DEA) tárolt változat
Borító:

3.

001-es BibID:BIBFORM096522
035-os BibID:(cikkazonosító)757078 (WoS)000717640900001 (Scopus)85118804752
Első szerző:Fekete Klára (neurológus)
Cím:Neurophysiological examinations as adjunctive tool to imaging techniques in spontaneous intracerebral haemorrhage : IRONHEART study / Fekete Klára, Tóth Judit, Horváth László, Márton Sándor, Héja Máté, Csiba László, Árokszállási Tamás, Bagoly Zsuzsa, Sulina Dóra, Fekete István
Dátum:2021
ISSN:1664-2295
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:Frontiers in Neurology. - 12 (2021), p. 1-15. -
További szerzők:Tóth Judit (1964-) (radiológus) Horváth László (1973-) (gyógyszerész) Márton Sándor (1965-) (matematikus) Héja Máté (1991-) (általános orvos) Csiba László (1952-) (neurológus, pszichiáter) Árokszállási Tamás (1988-) (neurológus) Bagoly Zsuzsa (1978-) (orvos) Sulina Dóra (PhD hallgató) Fekete István (1951-) (neurológus, pszichiáter)
Pályázati támogatás:K109712
OTKA
K120042
OTKA
FK128582
OTKA
GINOP-2.3.2-15-2016-00043
GINOP
Internet cím:DOI
Intézményi repozitóriumban (DEA) tárolt változat
Borító:

4.

001-es BibID:BIBFORM020672
Első szerző:Frendl Anita (neurológus)
Cím:Pharmacological and non-pharmacological recanalization strategies in acute ischemic stroke / Frendl Anita, Csiba László
Dátum:2011
Megjegyzések:According to the guidelines of the European Stroke Organization (ESO) and the American Stroke Association (ASA), acute stroke patients should be managed at stroke units that include well organized pre- and in-hospital care. In ischemic stroke the restoration of blood flow has to occur within a limited time window that is accomplished by fibrinolytic therapy. Newer generation thrombolytic agents (alteplase, pro-urokinase, reteplase, tenecteplase, desmoteplase) have shorter half-life and are more fibrin-specific. Only alteplase has Food and Drug Administration (FDA) approval for the treatment of acute stroke (1996). The National Institute of Neurological Disorders and Stroke (NINDS) trial proved that alteplase was effective in all subtypes of ischemic strokes within the first 3 h. In the European cooperative acute stroke study III trial, intravenous (IV) alteplase therapy was found to be safe and effective (with some restrictions) if applied within the first 3-4.5 h. In middle cerebral artery (MCA) occlusion additional transcranial Doppler insonication may improve the breakdown of the blood clot. According to the ESO and ASA guidelines, intra-arterial (IA) thrombolysis is an option for recanalization within 6 h of MCA occlusion. Further trials on the IA therapy are needed, as previous studies have involved relatively small number of patients (compared to IV trials) and the optimal IA dose of alteplase has not been determined (20-30 mg is used most commonly in 2 h). Patients undergoing combined (IV + IA) thrombolysis had significantly better outcome than the placebo group or the IV therapy alone in the NINDS trial (Interventional Management of Stroke trials). If thrombolysis fails or it is contraindicated, mechanical devices [e.g., mechanical embolus removal in cerebral ischemia (MERCI)- approved in 2004] might be used to remove the occluding clot. Stenting can also be an option in case of acute internal carotid artery occlusion in the future. An intra-aortic balloon was used to increase the collateral blood flow in the Safety and Efficacy of NeuroFlo(TM) Technology in Ischemic Stroke trial (results are under evaluation). Currently, there is no approved effective neuroprotective drug.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:Frontiers in neurology [electronic resource]. - 2 : 32 (2011), 11p. -
További szerzők:Csiba László (1952-) (neurológus, pszichiáter)
Internet cím:Intézményi repozitóriumban (DEA) tárolt változat
DOI
Borító:

5.

001-es BibID:BIBFORM106027
035-os BibID:(cikkazonosító)912664 (scopus)85137215772 (wos)000882813200001
Első szerző:Lóczi Linda
Cím:Thrombin generation as a predictor of outcomes in patients with non-traumatic intracerebral hemorrhage / Lóczi Linda, Orbán-Kálmándi Rita, Árokszállási Tamás, Fekete István, Fekete Klára, Héja Máté, Tóth Judit, Csiba László, Bagoly Zsuzsa
Dátum:2022
ISSN:1664-2295
Megjegyzések:Background: Non-traumatic intracerebral hemorrhage (ICH) accounts for 10-15% of all strokes and leads to a higher rate of mortality as compared to ischemic strokes. We aimed to find out whether the thrombin generation assay (TGA) could predict outcomes in patients with ICH. Patients and methods: In this prospective, observational study, 87 consecutive patients with ICH and 164 healthy controls were included. Computed tomography (CT), detailed clinical investigation, and laboratory investigations were performed from patients on admission. TGA was performed using stored platelet poor plasma obtained on admission. Lag time, endogen thrombin potential (ETP), peak thrombin, and time to peak parameters were calculated. Short- and long-term outcomes of ICH were defined at 14 days and 3 months post-event according to the NIHSS and the modified Rankin Scale (mRS), respectively. Results: Peak thrombin was significantly higher in patients as compared to controls (397.2 ? 93.9 vs. 306 ? 85.3 nM, p < 0.0001). Lag time, ETP, and time to peak parameters showed a significant positive correlation with CRP in both groups. In patients with worse long-term functional outcomes, peak thrombin was significantly higher as compared to those with favorable outcomes [mRS 2-6 median: 402.5 (IQR:344.8-473.8) vs. mRS 0-1: 326.4 (294.2-416.1) nM, p = 0.0096]. Based on the statistically optimal threshold of 339.1 nM peak thrombin, the sensitivity and specificity of this parameter to determine mRS 2-6 as an outcome were 80.8 and 64.7%, respectively. In a binary logistic regression model including age, sex, BMI, smoking status, NIHSS on admission, D-dimer, and peak thrombin (>339.1 nM), only NIHSS and the peak thrombin parameters remained in the model as significant, independent predictors of poor outcome. Lag time and time to peak showed a modest, significant negative correlation with intracerebral bleeding volume on admission (r = -0.2603, p = 0.0231 and r = -0.3698, p = 0.0010, respectively). During the follow-up of patients, estimated hemorrhage volumes on day 90 showed significant positive association with the ETP and peak thrombin parameters (r = 0.3838, p = 0.0363 and r = 0.5383, p = 0.0021, respectively). Conclusion: In patients with ICH, TG was increased as compared to healthy controls, which might be explained by the presence of higher inflammatory parameters in patients. Peak thrombin measured on admission might be a useful tool to predict outcomes in patients with ICH.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:Frontiers in Neurology. - 13 (2022), p. 1-12. -
További szerzők:Orbán-Kálmándi Rita Angéla (1993-) (klinikai laboratóriumi kutató) Árokszállási Tamás (1988-) (neurológus) Fekete István (1951-) (neurológus, pszichiáter) Fekete Klára (1978-) (neurológus) Héja Máté (1991-) (általános orvos) Tóth Judit (1964-) (radiológus) Csiba László (1952-) (neurológus, pszichiáter) Bagoly Zsuzsa (1978-) (orvos)
Pályázati támogatás:GINOP-2.3.2-15-2016-00043
GINOP
K120042
OTKA
FK128582
OTKA
ELKH-DE 332 Cerebrovascular and Neurodegenerative Research Group
Egyéb
ÚNKP 20-3-I-DE-220
Egyéb
Internet cím:Szerző által megadott URL
DOI
Intézményi repozitóriumban (DEA) tárolt változat
Borító:

6.

001-es BibID:BIBFORM092842
035-os BibID:(cikkazonosító)613441
Első szerző:Orbán-Kálmándi Rita Angéla (klinikai laboratóriumi kutató)
Cím:A Modified in vitro Clot Lysis Assay Predicts Outcomes in Non-traumatic Intracerebral Hemorrhage Stroke Patients : the IRONHEART Study / Rita Orbán-Kálmándi, Tamás Árokszállási, István Fekete, Klára Fekete, Máté Héja, Judit Tóth, Ferenc Sarkady, László Csiba, Zsuzsa Bagoly
Dátum:2021
ISSN:1664-2295 1664-2295
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:Frontiers in Neurology. - 12 (2021), p. 1-11. -
További szerzők:Árokszállási Tamás (1988-) (neurológus) Fekete István (1951-) (neurológus, pszichiáter) Fekete Klára (1978-) (neurológus) Héja Máté (1991-) (általános orvos) Tóth Judit (1964-) (radiológus) Sarkady Ferenc (1982-) (laboratóriumi analitikus) Csiba László (1952-) (neurológus, pszichiáter) Bagoly Zsuzsa (1978-) (orvos)
Pályázati támogatás:GINOP-2.3.2-15-2016-00043
GINOP
Internet cím:DOI
Intézményi repozitóriumban (DEA) tárolt változat
Borító:

7.

001-es BibID:BIBFORM116493
035-os BibID:(cikkazonosító)1226220 (scopus)85176564612 (WoS)001103983900001
Első szerző:Szegedi István (orvos)
Cím:Role of carotid duplex in the assessment of carotid artery restenosis after endarterectomy or stenting / Szegedi István, Potvorszki Fanni, Mészáros Zsófia Réka, Daniel Cecilia, Csiba László, Oláh László
Dátum:2023
ISSN:1664-2295
Megjegyzések:Introduction: Redo carotid endarterectomy (CEA) and carotid stenting (CAS) are often performed when there is evidence of post-procedural restenosis. The incidence of restenosis after carotid reconstruction is not negligible, ranging from 5 to 33%. The diagnosis of significant internal carotid artery (ICA) restenosis is usually based on duplex ultrasound (US) criteria, mostly on peak-systolic flow velocity (PSV). However, there have been no generally accepted duplex US criteria for carotid restenosis after CAS or CEA. Methods: In this systematic review, the PubMed/ Medline and Scopus databases were screened to find trials that reported duplex US criteria for significant restenosis after CEA and/or CAS. Only those reports were analyzed in which the restenoses were also assessed by CT/MR or digital subtraction angiography as comparators for duplex US. Results: Fourteen studies met the predetermined search criteria and were included in this review. In most studies, PSV thresholds for significant in-stent ICA restenosis after CAS were higher than those for significant stenosis in non- procedurally treated (native) ICA. Many fewer studies investigated the US criteria for ICA restenosis after CEA. Despite the heterogeneous data, there is a consensus to use higher flow velocity thresholds for assessment of stenosis in stented ICA than in native ICA; however, there have been insufficient data about the flow velocity criteria for significant restenosis after CEA. Although the flow velocity thresholds for restenosis after CAS and CEA seem to be different, the large studies used the same duplex criteria to define restenosis after the two procedures. Moreover, different studies used different flow velocity thresholds to define ICA restenosis, leading to variable restenosis rates. Discussion: We conclude that (1) further examinations are warranted to determine appropriate duplex US criteria for restenosis after CAS and CEA, (2) single duplex US parameter cannot be used to reliably determine the degree of ICA restenosis, (3) inappropriate US criteria used in large studies may have led to false restenosis rates, and (4) studies are required to determine if there is a benefit from redo carotid artery procedure, such as redo-CEA or redo-CAS, starting with prospective risk stratification studies using current best practice non-invasive care alone.
Tárgyszavak:Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
carotid artery stenting
carotid endarterectomy
carotid restenosis
ultrasound
systematic review
Megjelenés:Frontiers in Neurology. - 14 (2023), p. 1-14. -
További szerzők:Potvorszki Fanni Mészáros Zsófia Daniel Cecilia Csiba László (1952-) (neurológus, pszichiáter) Oláh László (1967-) (neurológus)
Internet cím:Szerző által megadott URL
DOI
Intézményi repozitóriumban (DEA) tárolt változat
Borító:

8.

001-es BibID:BIBFORM071630
Első szerző:Tóth Noémi Klára
Cím:Elevated factor VIII and von Willebrand factor levels predict unfavorable outcome in stroke patients treated with intravenous thrombolysis / Noémi Klára Tóth, Edina Gabriella Székely, Katalin Réka Czuriga-Kovács, Ferenc Sarkady, Orsolya Nagy, Levente István Lánczi, Ervin Berényi, Klára Fekete, István Fekete, László Csiba, Zsuzsa Bagoly
Dátum:2018
ISSN:1664-2295
Tárgyszavak:Orvostudományok Elméleti orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
folyóiratcikk
Megjelenés:Frontiers in neurology. - 8 (2018), p. 1-10. -
További szerzők:Székely Edina Gabriella Czuriga-Kovács Katalin Réka (1981-) (neurológus) Sarkady Ferenc (1982-) (laboratóriumi analitikus) Nagy Orsolya (1990-) (PhD hallgató) Lánczi Levente (1990-) (általános orvos) Berényi Ervin (1964-) (radiológus) Fekete Klára (1978-) (neurológus) Fekete István (1951-) (neurológus, pszichiáter) Csiba László (1952-) (neurológus, pszichiáter) Bagoly Zsuzsa (1978-) (orvos)
Pályázati támogatás:K109712
OTKA
K120042
OTKA
PD111929
OTKA
Internet cím:DOI
Intézményi repozitóriumban (DEA) tárolt változat
Borító:
Rekordok letöltése1