Találati lista | Tudóstér

001-es BibID:	BIBFORM007523
Első szerző:	Hossmann, Konstantin-Alexander
Cím:	Multiparametric imaging of blood flow and metabolism after middle cerebral artery occlusion in cats / Hossmann K. A., Mies G., Paschen W., Csiba L., Bodsch W., Rapin J. R., Leponcinlafitte M., Takahashi K.
Dátum:	1985
Megjegyzések:	In anesthetized adult cats, acute stroke was produced by transorbital occlusion of the left middle cerebral artery. A battery of imaging techniques was used for simultaneous evaluation of regional blood flow, glucose utilization, protein synthesis, pH, and the regional tissue content of glucose, ATP, and potassium. The electrophysiological impact of stroke was monitored by EEG frequency analysis and recording of somatosensory evoked potentials. Two hours after vascular occlusion, a close correlation existed between the degree of electrophysiological changes and biochemical alterations, in particular with the extent of tissue acidosis, ATP depletion, decrease of tissue potassium content, and suppression of protein synthesis. However, there was only a poor correlation with blood flow and glucose utilization. Both of these exhibited a greatly inhomogeneous pattern with regions of reduced, normal, or increased rates. In areas remote from the infarct, the content of biochemical substrates was normal but blood flow was reduced globally by approximately 50% and glucose utilization by approximately 20%. An anatomically defined regional pattern of cerebral or cerebellar diaschisis was not observed. It is concluded that during the acute phase of stroke, imaging of blood flow and glucose utilization does not provide an accurate estimate of the actual functional or metabolic disturbance. For the clinical evaluation of the development or treatment of stroke, in consequence, alternative noninvasive techniques such as imaging of protein synthesis and/or pH may be more relevant.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	Journal of Cerebral Blood Flow and Metabolism. - 5 (1985), p. 97-107. -
További szerzők:	Mies, Günter Paschen, Wulf Csiba László (1952-) (neurológus, pszichiáter) Bodsch, W. Rapin, J. R. Leponcinlafitte, M. Takahashi, Kentaro
Internet cím:	elektronikus változat DOI
Borító:
Saját polcon:

001-es BibID:	BIBFORM007506
Első szerző:	Hossmann, Konstantin-Alexander
Cím:	Relationship between calcium accumulation and recovery of cat brain after prolonged cerebral ischemia / Hossmann K. A., Paschen W., Csiba L.
Dátum:	1983
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	Journal of Cerebral Blood Flow and Metabolism. - 3 : 3 (1983), p. 346-353. -
További szerzők:	Paschen, Wulf Csiba László (1952-) (neurológus, pszichiáter)
Internet cím:	DOI
Borító:
Saját polcon:

001-es BibID:	BIBFORM013718
Első szerző:	Yonai, Yaniv
Cím:	Acetazolamide-induced vasodilation does not inhibit the visually evoked flow response / Yaniv Yonai, Neta Boms, Sandor Molnar, Bernhard Rosengarten, Natan M. Bornstein, Laszlo Csiba, Laszlo Olah
Dátum:	2010
ISSN:	0271-678X
Megjegyzések:	Different methods are used to assess the vasodilator ability of cerebral blood vessels; however, the exact mechanism of cerebral vasodilation, induced by different stimuli, is not entirely known. Our aim was to investigate whether the potent vasodilator agent, acetazolamide (AZ), inhibits the neurovascular coupling, which also requires vasodilation. Therefore, visually evoked flow parameters were examined by transcranial Doppler in ten healthy subjects before and after AZ administration. Pulsatility index and peak systolic flow velocity changes, evoked by visual stimulus, were recorded in the posterior cerebral arteries before and after intravenous administration of 15 mg/kg AZ. Repeated-measures ANOVA did not show significant group main effect between the visually evoked relative flow velocity time courses before and after AZ provocation (P=0.43). Visual stimulation induced significant increase of relative flow velocity and decrease of pulsatility index not only before but also at the maximal effect of AZ. These results suggest that maximal cerebral vasodilation cannot be determined by the clinically accepted dose of AZ (15 mg/kg) and prove that neurovascular coupling remains preserved despite AZ-induced vasodilation. Our observation indicates independent regulation of vasodilation during neurovascular coupling, allowing the adaptation of cerebral blood flow according to neuronal activity even if other processes require significant vasodilation.
Tárgyszavak:	Orvostudományok Klinikai orvostudományok idegen nyelvű folyóiratközlemény külföldi lapban
Megjelenés:	Journal of Cerebral Blood Flow and Metabolism. - 30 : 3 (2010), p. 516-521. -
További szerzők:	Boms, Neta Molnár Sándor (1973-) (neurológus) Rosengarten, Bernhard Bornstein, Natan M. Csiba László (1952-) (neurológus, pszichiáter) Oláh László (1967-) (neurológus)
Pályázati támogatás:	0271-678x/10 Egyéb ETT 260/2009 Egyéb ETT 197-05/2010 Egyéb
Internet cím:	Intézményi repozitóriumban (DEA) tárolt változat DOI
Borító:
Saját polcon: